The Effect of Methyl-Derivatives of Flavanone on MCP-1, MIP-1β, RANTES, and Eotaxin Release by Activated RAW264.7 Macrophages Article Swipe
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· 2024
· Open Access
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· DOI: https://doi.org/10.3390/molecules29102239
Chemokines, also known as chemotactic cytokines, stimulate the migration of immune cells. These molecules play a key role in the pathogenesis of inflammation leading to atherosclerosis, neurodegenerative disorders, rheumatoid arthritis, insulin-resistant diabetes, and cancer. Moreover, they take part in inflammatory bowel disease (IBD). The main objective of our research was to determine the activity of methyl-derivatives of flavanone, namely, 2′-methylflavanone (5B), 3′-methylflavanone (6B), 4′-methylflavanone (7B), and 6-methylflavanone (8B), on the releasing of selected cytokines by RAW264.7 macrophages activated by LPS. We determined the concentration of chemokines belonging to the CC chemokine family, namely, MCP-1, MIP-1β, RANTES, and eotaxin, using the Bio-Plex Magnetic Luminex Assay and the Bio-PlexTM 200 System. Among the tested compounds, only 5B and 6B had the strongest effect on inhibiting the examined chemokines’ release by macrophages. Therefore, 5B and 6B appear to be potentially useful in the prevention of diseases associated with the inflammatory process.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules29102239
- https://www.mdpi.com/1420-3049/29/10/2239/pdf?version=1715329636
- OA Status
- gold
- Cited By
- 3
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396803750
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4396803750Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/molecules29102239Digital Object Identifier
- Title
-
The Effect of Methyl-Derivatives of Flavanone on MCP-1, MIP-1β, RANTES, and Eotaxin Release by Activated RAW264.7 MacrophagesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-10Full publication date if available
- Authors
-
Małgorzata Kłósek, Anna Kurek-Górecka, Radosław Balwierz, Agnieszka Krawczyk-Łebek, Edyta Kostrzewa-Susłow, Joanna Bronikowska, Dagmara Jaworska, Zenon CzubaList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules29102239Publisher landing page
- PDF URL
-
https://www.mdpi.com/1420-3049/29/10/2239/pdf?version=1715329636Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1420-3049/29/10/2239/pdf?version=1715329636Direct OA link when available
- Concepts
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Eotaxin, Chemokine, Inflammation, Immunology, Immune system, Rheumatoid arthritis, Pathogenesis, Chemotaxis, Medicine, Chemistry, Cancer research, Pharmacology, Biochemistry, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
67Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5081087041, https://openalex.org/A5029059476 |
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| corresponding_institution_ids | https://openalex.org/I166182418, https://openalex.org/I864159182 |
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