The effect of primary granulocyte-colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with testicular germ cell tumors Article Swipe
Nikola Hapakova
,
Michal Chovanec
,
Katarína Rejleková
,
Katarína Kaľavská
,
Jana Obertová
,
Patrik Palacka
,
Valentina De Angelis
,
Daniela Světlovská
,
Zuzana Syčová-Milá
,
Jozef Mardiak
,
Michal Mego
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-46060/v2
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-46060/v2
Background: Testicular germ cell tumors (GCTs) are the most common solid malignancy in men 15-35 years old. Febrile neutropenia (FN) is a serious complication of chemotherapy, frequently occurring in GCT patients. The aim of this retrospective study was to assess the effect of primary granulocyte-colony stimulating factor (G-CSF) prophylaxis on the incidence of FN in GCT patients. Methods: This study was conducted from medical records database of GCTs patients treated with first line/adjuvant chemotherapy from January 2000 to December 2017. Starting in January 2006, patients received G-CSF prophylaxis after every cycle of chemotherapy. Results: Out of 385 patients, 264 patients received primary G-CSF prophylaxis and 121 patients did not receive prophylaxis. During the study period, 71 patients (18.4%) suffered FN events. Out of 121 patients who did not receive primary prophylaxis, 42 patients suffered FN, while only 29 patients with primary prophylaxis suffered FN (34.7% vs 11.0%, P = 0.00000003). On subgroup analysis, FN incidence decreased in all groups with primary prophylaxis, except for patients with stage I GCT receiving adjuvant chemotherapy. Patients receiving G-CSF prophylaxis had significantly longer overall survival when compared to patients without prophylaxis. (HR = 0.54, 95% CI 0.31-0.96; P = 0.0235). Conclusions: Primary G-CSF prophylaxis was associated with significantly decreased FN incidence in patients treated with first line chemotherapy for metastatic disease. Patients receiving G-CSF prophylaxis had significantly longer overall survival. We suggest, that primary G-CSF prophylaxis should be considered in GCT patients receiving first line chemotherapy.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-46060/v2
- OA Status
- green
- References
- 14
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4210337900
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4210337900Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-46060/v2Digital Object Identifier
- Title
-
The effect of primary granulocyte-colony stimulating factor prophylaxis on the incidence of febrile neutropenia in patients with testicular germ cell tumorsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-31Full publication date if available
- Authors
-
Nikola Hapakova, Michal Chovanec, Katarína Rejleková, Katarína Kaľavská, Jana Obertová, Patrik Palacka, Valentina De Angelis, Daniela Světlovská, Zuzana Syčová-Milá, Jozef Mardiak, Michal MegoList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-46060/v2Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.21203/rs.3.rs-46060/v2Direct OA link when available
- Concepts
-
Medicine, Febrile neutropenia, Neutropenia, Internal medicine, Chemotherapy, Incidence (geometry), Granulocyte colony-stimulating factor, Gastroenterology, Complication, Antibiotic prophylaxis, Malignancy, Surgery, Antibiotics, Optics, Physics, Biology, MicrobiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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14Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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