The effect of the combination of TGF-β1 and BMP2 with high-density pellet cell culture during chondrogenic differentiation of pluripotent stem cells. Article Swipe
Michał Lach
,
Wiktoria Maria Suchorska
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21641/los.2020.17.1.169
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21641/los.2020.17.1.169
Introduction: The osteoarthritis is a serious threat for well-developed and ageing countries. Present techniques of treatment of damaged cartilage are not sufficient. Hence, new strategies should be developed. One of the potential sources for the regeneration of cartilage is pluripotent stem cells (PSC). Aim: The development of an efficient protocol of chondrogenic differentiation using PSC. Material and methods: The human embryonic stem cell line (BG01V) was used in this study. The chondrogenic differentiation was performed using high-density pellet culture in the presence of TGF-β1 (10 ng/ml) and BMP2 (100 ng/ml). After 21 days gene expression analysis of markers related to chondrogenesis was done. Additionally, the histological staining was performed to detect the deposition of proteoglycans and collagens in differentiated pellet culture. Results: Obtained pellets exhibited decreased expression of pluripotent markers. The upregulation of mesodermal marker and type II collagen was observed in differentiated pellets in the presence of applied growth factors. The histological analysis revealed mild deposition of proteoglycans and collagens. Conclusion: The presented approach enables to obtain chondrogenic pellets in their early stages of chondrogenesis.
Related Topics
Concepts
Chondrogenesis
Induced pluripotent stem cell
Cell biology
Embryonic stem cell
Stem cell
Cartilage
Bone morphogenetic protein 2
Cellular differentiation
Chemistry
Biology
Anatomy
Biochemistry
Gene
In vitro
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.21641/los.2020.17.1.169
- https://journals.wco.pl/los/article/download/169/175
- OA Status
- diamond
- References
- 55
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3014048606Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21641/los.2020.17.1.169Digital Object Identifier
- Title
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The effect of the combination of TGF-β1 and BMP2 with high-density pellet cell culture during chondrogenic differentiation of pluripotent stem cells.Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-03-17Full publication date if available
- Authors
-
Michał Lach, Wiktoria Maria SuchorskaList of authors in order
- Landing page
-
https://doi.org/10.21641/los.2020.17.1.169Publisher landing page
- PDF URL
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https://journals.wco.pl/los/article/download/169/175Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://journals.wco.pl/los/article/download/169/175Direct OA link when available
- Concepts
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Chondrogenesis, Induced pluripotent stem cell, Cell biology, Embryonic stem cell, Stem cell, Cartilage, Bone morphogenetic protein 2, Cellular differentiation, Chemistry, Biology, Anatomy, Biochemistry, Gene, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.their | 171 |
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