Research Square (Research Square)
The Effect of Upfront Intensive Therapy on Primary Resistance in Metastatic Castration-sensitive Prostate Cancer: A Multicenter Retrospective Study
August 2021 • Toshikazu Tanaka, Shingo Hatakeyama, Daisuke Noro, Hirotake Kodama, Sakae Konishi, Kazutaka Okita, Shogo Hosogoe, Kai Ozaki, Takuma Narita, Noriko To…
Abstract We investigated the effect of upfront intensive therapy on primary resistance in patients with metastatic castration-sensitive prostate cancer (mCSPC) in real-world practice. We retrospectively evaluated the medical records of 348 patients with newly diagnosed mCSPC who had a high tumor-burden between January 2008 and May 2021. We compared the oncological outcomes between patients who received conventional androgen deprivation therapy ± bicalutamide (ADT group) and those treated with upfront intensive the…