The effectiveness of platelet-rich plasma gel on full-thickness cartilage defect repair in a rabbit model Article Swipe
Fathia Slimi
,
Wassim Zribi
,
Mœz Trigui
,
R. Amri
,
Nawrez Gouiaa
,
Cyrine Abid
,
Mohamed Rebaı̈
,
Tahia Boudawara
,
Samira Jebahi
,
Hassib Keskes
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1302/2046-3758.103.bjr-2020-0087.r2
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1302/2046-3758.103.bjr-2020-0087.r2
Aims The present study investigates the effectiveness of platelet-rich plasma (PRP) gel without adjunct to induce cartilage regeneration in large osteochondral defects in a rabbit model. Methods A bilateral osteochondral defect was created in the femoral trochlear groove of 14 New Zealand white rabbits. The right knees were filled with PRP gel and the contralateral knees remained untreated and served as control sides. Some animals were killed at week 3 and others at week 12 postoperatively. The joints were harvested and assessed by Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) MRI scoring system, and examined using the International Cartilage Repair Society (ICRS) macroscopic and ICRS histological scoring systems. Additionally, the collagen type II content was evaluated by the immunohistochemical staining. Results After 12 weeks post-surgery, the defects of the PRP group were repaired by hyaline cartilage-like tissue. However, incomplete cartilage regeneration was observed in the PRP group for three weeks. The control groups showed fibrocartilaginous or fibrous tissue, respectively, at each timepoint. Conclusion Our study proved that the use of PRP gel without any adjuncts could successfully produce a good healing response and resurface the osteochondral defect with a better quality of cartilage in a rabbit model. Cite this article: Bone Joint Res 2021;10(3):192–202.
Related Topics
Concepts
Cartilage
Platelet-rich plasma
Medicine
Regeneration (biology)
Hyaline cartilage
Staining
Immunohistochemistry
Pathology
Surgery
Anatomy
Platelet
Osteoarthritis
Articular cartilage
Internal medicine
Biology
Cell biology
Alternative medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1302/2046-3758.103.bjr-2020-0087.r2
- OA Status
- gold
- Cited By
- 22
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3136467866
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3136467866Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1302/2046-3758.103.bjr-2020-0087.r2Digital Object Identifier
- Title
-
The effectiveness of platelet-rich plasma gel on full-thickness cartilage defect repair in a rabbit modelWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-03-01Full publication date if available
- Authors
-
Fathia Slimi, Wassim Zribi, Mœz Trigui, R. Amri, Nawrez Gouiaa, Cyrine Abid, Mohamed Rebaı̈, Tahia Boudawara, Samira Jebahi, Hassib KeskesList of authors in order
- Landing page
-
https://doi.org/10.1302/2046-3758.103.bjr-2020-0087.r2Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1302/2046-3758.103.bjr-2020-0087.r2Direct OA link when available
- Concepts
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Cartilage, Platelet-rich plasma, Medicine, Regeneration (biology), Hyaline cartilage, Staining, Immunohistochemistry, Pathology, Surgery, Anatomy, Platelet, Osteoarthritis, Articular cartilage, Internal medicine, Biology, Cell biology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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22Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 8, 2023: 3, 2022: 8Per-year citation counts (last 5 years)
- References (count)
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40Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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