The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays Article Swipe
Otilija Keta
,
Vladana Petković
,
Neda Đorđević
,
M. Dordevic
,
Branka Ivković
,
Vladimir Dobričić
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.46793/iccbi23.471k
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.46793/iccbi23.471k
Given the well-established potential of chalcones in modulating the response of cancer cells to therapeutic interventions, coupled with the growing imperative to enhance their biological attributes, the objective of this study was to synthesize a methoxy-substituted chalcone (OCH3) and assess its capacity to amplify the inhibitory effects of radiation in melanoma cells known for their resistance to radiotherapy. The A375 melanoma cells were subjected to a clinically relevant dose of 2 Gy gamma irradiation. OCH3 was employed either as a standalone treatment or in conjunction with irradiation. The obtained results unveiled the substantial radiosensitizing potential of OCH3 within this specific cell line. Our subsequent investigations will be designed to investigate the underlying mechanisms that contribute to the radiosensitizing properties of OCH3. Moreover, we intend to evaluate the efficacy of OCH3 against other types of radioresistant cancer cells. The presented data not only illuminates the enhanced therapeutic possibilities offered by OCH3 but also highlights its potential as a valuable agent in addressing a wider array of challenging malignancies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.46793/iccbi23.471k
- https://drive.google.com/file/d/1E8WAYsj5CUH6vaD9jumnbktfpTHTmI9F/view
- OA Status
- gold
- References
- 9
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388053126
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388053126Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.46793/iccbi23.471kDigital Object Identifier
- Title
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The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-raysWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-01Full publication date if available
- Authors
-
Otilija Keta, Vladana Petković, Neda Đorđević, M. Dordevic, Branka Ivković, Vladimir DobričićList of authors in order
- Landing page
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https://doi.org/10.46793/iccbi23.471kPublisher landing page
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https://drive.google.com/file/d/1E8WAYsj5CUH6vaD9jumnbktfpTHTmI9F/viewDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://drive.google.com/file/d/1E8WAYsj5CUH6vaD9jumnbktfpTHTmI9F/viewDirect OA link when available
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Radioresistance, Melanoma, Chalcone, Cancer research, Irradiation, Radiation therapy, Cancer, Cancer cell, Cell culture, Medicine, Chemistry, Biology, Internal medicine, Physics, Stereochemistry, Nuclear physics, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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9Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.modulating | 7 |
| abstract_inverted_index.properties | 118 |
| abstract_inverted_index.resistance | 55 |
| abstract_inverted_index.standalone | 80 |
| abstract_inverted_index.subsequent | 103 |
| abstract_inverted_index.synthesize | 33 |
| abstract_inverted_index.underlying | 111 |
| abstract_inverted_index.attributes, | 25 |
| abstract_inverted_index.challenging | 165 |
| abstract_inverted_index.conjunction | 84 |
| abstract_inverted_index.illuminates | 142 |
| abstract_inverted_index.investigate | 109 |
| abstract_inverted_index.substantial | 92 |
| abstract_inverted_index.therapeutic | 14, 145 |
| abstract_inverted_index.irradiation. | 73, 86 |
| abstract_inverted_index.malignancies. | 166 |
| abstract_inverted_index.possibilities | 146 |
| abstract_inverted_index.radiotherapy. | 57 |
| abstract_inverted_index.interventions, | 15 |
| abstract_inverted_index.investigations | 104 |
| abstract_inverted_index.radioresistant | 134 |
| abstract_inverted_index.radiosensitizing | 93, 117 |
| abstract_inverted_index.well-established | 2 |
| abstract_inverted_index.methoxy-substituted | 35 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 6 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7300000190734863 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.16984217 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |