The effects of cardiac structure, valvular regurgitation, and left ventricular diastolic dysfunction on the diagnostic accuracy of Murray law–based quantitative flow ratio Article Swipe
YOU?
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· 2023
· Open Access
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· DOI: https://doi.org/10.3389/fcvm.2023.1134623
Objective The study aimed to investigate the diagnostic accuracy of Murray law–based quantitative flow ratio (μQFR) from a single angiographic view in patients with abnormal cardiac structure, left ventricular diastolic dysfunction, and valvular regurgitation. Background μQFR is a novel fluid dynamics method for deriving fractional flow reserve (FFR). In addition, current studies of μQFR mainly analyzed patients with normal cardiac structure and function. The accuracy of μQFR when patients had abnormal cardiac structure, left ventricular diastolic dysfunction, and valvular regurgitation has not been clear. Methods This study retrospectively analyzed 261 patients with 286 vessels that underwent both FFR and μQFR prior to intervention. The cardiac structure and function were measured using echocardiography. Pressure wire–derived FFR ≤0.80 was defined as hemodynamically significant coronary stenosis. Results μQFR had a moderate correlation with FFR ( r = 0.73, p < 0.001), and the Bland–Altman plot presented no difference between the μQFR and FFR (0.006 ± 0.075, p = 0.192). With FFR as the standard, the diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of μQFR were 94.06% (90.65–96.50), 82.56% (72.87–89.90), 99.00% (96.44–99.88), 97.26 (89.91–99.30), and 92.96% (89.29–95.44), respectively. The concordance of μQFR/FFR was not associated with abnormal cardiac structure, valvular regurgitation (aortic valve, mitral valve, and tricuspid valve), and left ventricular diastolic function. Coronary hemodynamics showed no difference between normality and abnormality of cardiac structure and left ventricular diastolic function. Coronary hemodynamics demonstrated no difference among valvular regurgitation (none, mild, moderate, or severe). Conclusion μQFR showed an excellent agreement with FFR. The effect of abnormal cardiac structure, valvular regurgitation, and left ventricular diastolic function did not correlate with the diagnostic accuracy of μQFR. Coronary hemodynamics showed no difference in patients with abnormal cardiac structure, valvular regurgitation, and left ventricular diastolic function.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcvm.2023.1134623
- https://www.frontiersin.org/articles/10.3389/fcvm.2023.1134623/pdf
- OA Status
- gold
- Cited By
- 4
- References
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- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4377942716Canonical identifier for this work in OpenAlex
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https://doi.org/10.3389/fcvm.2023.1134623Digital Object Identifier
- Title
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The effects of cardiac structure, valvular regurgitation, and left ventricular diastolic dysfunction on the diagnostic accuracy of Murray law–based quantitative flow ratioWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-05-24Full publication date if available
- Authors
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Junqing Yang, Yuming Huang, Xiaoshan Li, Qianjun Jia, Huiliang Deng, Nianjin Xie, Meiping Huang, Hongwen FeiList of authors in order
- Landing page
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https://doi.org/10.3389/fcvm.2023.1134623Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1134623/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1134623/pdfDirect OA link when available
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Cardiology, Medicine, Internal medicine, Diastole, Regurgitation (circulation), Mitral regurgitation, Blood pressureTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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