The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers Article Swipe
Yu Chen
,
XingGuang Luo
,
Huey-Ting Li
,
Guangfei Li
,
Jaime S. Ide
,
Chiang-Shan R. Li
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41398-025-03719-3
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41398-025-03719-3
Extensive research has documented altered emotion processing in binge drinkers. Genetic risks contribute to problem drinking; however, it remains unclear how genetic risks for alcohol misuse affect behavioral and brain responses to negative emotions. We curated data from the Human Connectome Project and identified 97 binge (69 men) and 379 demographically-matched non-binge (142 men) drinkers performing an emotion task during brain imaging. Alcohol use severity was quantified by the first principal component (PC1) identified of principal component analysis of 15 drinking measures. Polygenic risk scores (PRS) for alcohol dependence were computed for all subjects. With published routines and at a corrected threshold, we evaluated how brain responses to matching negative emotional faces vs. geometric shapes associated with PC1 and PRS in a linear regression, with age, sex, and race as covariates. Higher PC1 and PRS were both significantly correlated with greater symptom severity of somatic complaints in binge drinkers. Bingers relative to non-bingers showed stronger activation of a wide array of frontal, parietal and occipital regions and the insula in positive correlation with the PRS. These genetic risk markers featured more prominently in male than in female binge drinkers. In contrast, regional responses in the default mode network may represent sex-shared markers of the genetic risks. These findings suggest altered neurobiological processes of negative emotions in correlation with genetic risks for alcohol misuse in binge drinkers. Longitudinal studies are needed to show how dysfunctional negative emotion processing interlinks the genetic risks and problem drinking.
Related Topics
Concepts
Binge drinking
Psychology
Dysfunctional family
Young adult
Clinical psychology
Alcohol use disorder
Alcohol dependence
Affect (linguistics)
Endophenotype
Diathesis–stress model
Insula
Genetic correlation
Correlation
Functional magnetic resonance imaging
Psychiatry
Default mode network
Event-related potential
Neuroimaging
Poison control
Developmental psychology
Brain mapping
Negative emotion
Psychopathology
Medicine
Brain activity and meditation
Injury prevention
Schizophrenia (object-oriented programming)
Cannabis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41398-025-03719-3
- https://www.nature.com/articles/s41398-025-03719-3.pdf
- OA Status
- gold
- References
- 105
- OpenAlex ID
- https://openalex.org/W7106331777
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106331777Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41398-025-03719-3Digital Object Identifier
- Title
-
The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkersWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-21Full publication date if available
- Authors
-
Yu Chen, XingGuang Luo, Huey-Ting Li, Guangfei Li, Jaime S. Ide, Chiang-Shan R. LiList of authors in order
- Landing page
-
https://doi.org/10.1038/s41398-025-03719-3Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41398-025-03719-3.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41398-025-03719-3.pdfDirect OA link when available
- Concepts
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Binge drinking, Psychology, Dysfunctional family, Young adult, Clinical psychology, Alcohol use disorder, Alcohol dependence, Affect (linguistics), Endophenotype, Diathesis–stress model, Insula, Genetic correlation, Correlation, Functional magnetic resonance imaging, Psychiatry, Default mode network, Event-related potential, Neuroimaging, Poison control, Developmental psychology, Brain mapping, Negative emotion, Psychopathology, Medicine, Brain activity and meditation, Injury prevention, Schizophrenia (object-oriented programming), CannabisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
105Number of works referenced by this work
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