The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy Article Swipe
Related Concepts
Biology
Cell cycle
Chemotherapy
Programmed cell death
Cell biology
DNA damage
Cell growth
Cell
Cell cycle progression
Cell cycle checkpoint
Apoptosis
Cancer research
DNA
Genetics
Adrián E. Granada
,
Alba Jiménez
,
Jacob Stewart-Ornstein
,
Nils Blüthgen
,
Simone Reber
,
Ashwini Jambhekar
,
Galit Lahav
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1091/mbc.e19-09-0515
· OA: W3005803699
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1091/mbc.e19-09-0515
· OA: W3005803699
DNA-damaging chemotherapy often leaves residual tumor cells. Combining single-cell long-term live imaging with information theory, we found an unexpected effect: highly proliferative cells were more likely to arrest than to die, whereas more slowly proliferating cells showed a higher probability of death.
Related Topics
Finding more related topics…