The Efficacy of Rosa damascena on Liver Enzymes in Nonalcoholic Fatty Liver Disease: A Randomized Double-Blind Clinical Trial Article Swipe
Seyed Ali Al-Hadi Moravej
,
Asie Shojaii
,
Fataneh Hashem-Dabaghian
,
Seyede Ferdos Jazayeri
,
S. Zahra Moravej
,
Ebrahim Khadem
,
Shahram Agah
,
Roshanak Ghods
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1155/2021/6628911
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1155/2021/6628911
Objective. This study aimed to appraise the potential effects of Rosa damascena preparation on nonalcoholic fatty liver disease (NAFLD). Design. In the randomized, double-blind placebo-controlled clinical trials, seventy-four patients with NAFLD were prescribed either 1 g Rosa damascena powder or placebo three times in a day for 12 weeks. All patients were provided the lifestyle modification instructions and recommended following them precisely. ALT, AST, FBS, and lipid profiles were measured at the baseline after 12 weeks of studying. The Mann–Whitney U test was correctly used to compare the changes of variables among the groups. Results. Seventy-two patients completed the study in two groups. Sixty-seven patients were men, and the mean ± standard deviation of age was 40.11 ± 9.05 years. The Rosa damascena group showed a considerable decrease in the serum ALT (23.83 ± 24.82 vs. 16.19 ± 27.41, p = 0.042 ), waist circumference (99.73 ± 10.01 vs. 101.52 ± 8.84, p = 0.003 ), triglyceride (TG) (186.29 ± 76.75 vs. 184.47 ± 73.05, p = 0.001 ), cholesterol (167.47 ± 34.48 vs. 184.11 ± 33.54, p = 0.001 ), low-density lipoprotein (LDL) (99.17 ± 28.66 vs. 107.52 ± 25.42, p = 0.001 ), and elevation in serum high-density lipoprotein (HDL) (41.85 ± 6.56 vs. 39.20 ± 5.00, p < 0.007 ) compared to the control group. Improving fatty liver degree due to liver ultrasound was higher in the Rosa damascena group than the control group ( p = 0.001 ). Conclusion. Rosa damascena meaningfully improves liver function in NAFLD. Hence, it can be recommended along with lifestyle modification for these patients. Further studies are recommended with a larger sample size.
Related Topics
Concepts
Rosa × damascena
Nonalcoholic fatty liver disease
Medicine
Placebo
Internal medicine
Gastroenterology
Double blind
Triglyceride
Waist
Fatty liver
Lipid profile
Liver enzyme
Blood lipids
Traditional medicine
Cholesterol
Biology
Obesity
Food science
Pathology
Disease
Alternative medicine
Essential oil
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2021/6628911
- https://downloads.hindawi.com/journals/ecam/2021/6628911.pdf
- OA Status
- hybrid
- Cited By
- 3
- References
- 17
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3194028943
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3194028943Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1155/2021/6628911Digital Object Identifier
- Title
-
The Efficacy of Rosa damascena on Liver Enzymes in Nonalcoholic Fatty Liver Disease: A Randomized Double-Blind Clinical TrialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-12Full publication date if available
- Authors
-
Seyed Ali Al-Hadi Moravej, Asie Shojaii, Fataneh Hashem-Dabaghian, Seyede Ferdos Jazayeri, S. Zahra Moravej, Ebrahim Khadem, Shahram Agah, Roshanak GhodsList of authors in order
- Landing page
-
https://doi.org/10.1155/2021/6628911Publisher landing page
- PDF URL
-
https://downloads.hindawi.com/journals/ecam/2021/6628911.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://downloads.hindawi.com/journals/ecam/2021/6628911.pdfDirect OA link when available
- Concepts
-
Rosa × damascena, Nonalcoholic fatty liver disease, Medicine, Placebo, Internal medicine, Gastroenterology, Double blind, Triglyceride, Waist, Fatty liver, Lipid profile, Liver enzyme, Blood lipids, Traditional medicine, Cholesterol, Biology, Obesity, Food science, Pathology, Disease, Alternative medicine, Essential oilTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
17Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.<e:mn>0.001</e:mn> | 178 |
| abstract_inverted_index.<g:mn>0.001</g:mn> | 194 |
| abstract_inverted_index.<i:mn>0.001</i:mn> | 212 |
| abstract_inverted_index.<k:mn>0.007</k:mn> | 234 |
| abstract_inverted_index.<m:mn>0.001</m:mn> | 267 |
| abstract_inverted_index.placebo-controlled | 24 |
| abstract_inverted_index.xmlns:a="http://www.w3.org/1998/Math/MathML" | 140 |
| abstract_inverted_index.xmlns:c="http://www.w3.org/1998/Math/MathML" | 157 |
| abstract_inverted_index.xmlns:e="http://www.w3.org/1998/Math/MathML" | 174 |
| abstract_inverted_index.xmlns:g="http://www.w3.org/1998/Math/MathML" | 190 |
| abstract_inverted_index.xmlns:i="http://www.w3.org/1998/Math/MathML" | 208 |
| abstract_inverted_index.xmlns:k="http://www.w3.org/1998/Math/MathML" | 230 |
| abstract_inverted_index.xmlns:m="http://www.w3.org/1998/Math/MathML" | 263 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5078090459 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I161106909 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6499999761581421 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.50291386 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |