The Evaluation of the Effects of Two Probiotic Strains on the Oral Ecosystem: A Randomized Clinical Trial Article Swipe
C.M.C. Volgenant
,
Suzette V. van der Waal
,
Bernd W. Brandt
,
M.J. Buijs
,
Monique H. van der Veen
,
NAM Rosema
,
Bernd L. Fiebich
,
Thorsten Rose
,
Tim Schmitter
,
Max Gajfulin
,
Wim Crielaard
,
Egija Zaura
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/froh.2022.825017
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/froh.2022.825017
Introduction In the current study, we evaluated the effectiveness of two well-defined probiotic strains, Lactobacillus paracasei LPc-G110 (CCTCC M 2013691) and Lactobacillus plantarum GOS42 (DSM 32131), during an experimental gingivitis challenge. The primary objective was to evaluate clinically the effectiveness of lozenges containing one of the two oral probiotic strains, compared with placebo lozenges, on the gingival bleeding (bleeding on marginal probing; BOMP change) after a two-week experimental gingivitis period. The secondary objectives were to assess the effects of the test products on gingival health (Modified Gingival Index; MGI), dental plaque accumulation and fluorescence, and the dynamics of immunological and microbiological aspects after the wash-in phase, followed by a two-week period refraining from oral hygiene and a two-week wash-out phase. Methods This single-center challenge intervention study was a triple-blind randomized placebo-controlled clinical trial with three parallel groups. The full study population consisted of 117 healthy 18–55 years old human volunteers. Subjects were instructed to use one lozenge, 3 times daily after each meal, containing either L. plantarum, L. paracasei , or lozenges without probiotics (placebo group). After a 2-week wash-in period, the subjects were requested to refrain from any form of oral hygiene for 2 weeks. Results There were no differences in the primary outcome (BOMP change) among the groups. However, gingival health (MGI) in individuals from the groups exposed to the test products recovered better from experimental gingivitis than the individuals in the placebo group ( p = 0.021, one-way ANOVA). The two test products inhibited pro-inflammatory cytokine IL-1ß production, measured in saliva, during the experimental gingivitis period. Both test strains significantly reduced bacterial DNA in tongue samples and L. paracasei strain showed stronger microbiome-modulating potential than the L. plantarum strain. Conclusions The two tested lozenges with the L. paracasei or L. plantarum strains did show potential for beneficial effects for the oral health of the host during experimental gingivitis to the oral ecosystem.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/froh.2022.825017
- OA Status
- gold
- Cited By
- 7
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4221109238
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4221109238Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/froh.2022.825017Digital Object Identifier
- Title
-
The Evaluation of the Effects of Two Probiotic Strains on the Oral Ecosystem: A Randomized Clinical TrialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-03-30Full publication date if available
- Authors
-
C.M.C. Volgenant, Suzette V. van der Waal, Bernd W. Brandt, M.J. Buijs, Monique H. van der Veen, NAM Rosema, Bernd L. Fiebich, Thorsten Rose, Tim Schmitter, Max Gajfulin, Wim Crielaard, Egija ZauraList of authors in order
- Landing page
-
https://doi.org/10.3389/froh.2022.825017Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/froh.2022.825017Direct OA link when available
- Concepts
-
Probiotic, Randomized controlled trial, Ecosystem, Medicine, Food science, Internal medicine, Biology, Ecology, Bacteria, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 6, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4221109238 |
|---|---|
| doi | https://doi.org/10.3389/froh.2022.825017 |
| ids.doi | https://doi.org/10.3389/froh.2022.825017 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35434705 |
| ids.openalex | https://openalex.org/W4221109238 |
| fwci | 1.64597822 |
| type | article |
| title | The Evaluation of the Effects of Two Probiotic Strains on the Oral Ecosystem: A Randomized Clinical Trial |
| biblio.issue | |
| biblio.volume | 3 |
| biblio.last_page | 825017 |
| biblio.first_page | 825017 |
| topics[0].id | https://openalex.org/T10257 |
| topics[0].field.id | https://openalex.org/fields/35 |
| topics[0].field.display_name | Dentistry |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/3506 |
| topics[0].subfield.display_name | Periodontics |
| topics[0].display_name | Oral microbiology and periodontitis research |
| topics[1].id | https://openalex.org/T10368 |
| topics[1].field.id | https://openalex.org/fields/35 |
| topics[1].field.display_name | Dentistry |
| topics[1].score | 0.9987999796867371 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/3506 |
| topics[1].subfield.display_name | Periodontics |
| topics[1].display_name | Dental Health and Care Utilization |
| topics[2].id | https://openalex.org/T10141 |
| topics[2].field.id | https://openalex.org/fields/11 |
| topics[2].field.display_name | Agricultural and Biological Sciences |
| topics[2].score | 0.9977999925613403 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1106 |
| topics[2].subfield.display_name | Food Science |
| topics[2].display_name | Probiotics and Fermented Foods |
| is_xpac | False |
| apc_list.value | 1900 |
| apc_list.currency | USD |
| apc_list.value_usd | 1900 |
| apc_paid.value | 1900 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 1900 |
| concepts[0].id | https://openalex.org/C2780255968 |
| concepts[0].level | 3 |
| concepts[0].score | 0.833156168460846 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1816730 |
| concepts[0].display_name | Probiotic |
| concepts[1].id | https://openalex.org/C168563851 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6548352241516113 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1436668 |
| concepts[1].display_name | Randomized controlled trial |
| concepts[2].id | https://openalex.org/C110872660 |
| concepts[2].level | 2 |
| concepts[2].score | 0.42585426568984985 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q37813 |
| concepts[2].display_name | Ecosystem |
| concepts[3].id | https://openalex.org/C71924100 |
| concepts[3].level | 0 |
| concepts[3].score | 0.4189993739128113 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[3].display_name | Medicine |
| concepts[4].id | https://openalex.org/C31903555 |
| concepts[4].level | 1 |
| concepts[4].score | 0.3578764796257019 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1637030 |
| concepts[4].display_name | Food science |
| concepts[5].id | https://openalex.org/C126322002 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3255169987678528 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[5].display_name | Internal medicine |
| concepts[6].id | https://openalex.org/C86803240 |
| concepts[6].level | 0 |
| concepts[6].score | 0.2929752469062805 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[6].display_name | Biology |
| concepts[7].id | https://openalex.org/C18903297 |
| concepts[7].level | 1 |
| concepts[7].score | 0.18297645449638367 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7150 |
| concepts[7].display_name | Ecology |
| concepts[8].id | https://openalex.org/C523546767 |
| concepts[8].level | 2 |
| concepts[8].score | 0.10826835036277771 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q10876 |
| concepts[8].display_name | Bacteria |
| concepts[9].id | https://openalex.org/C54355233 |
| concepts[9].level | 1 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[9].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/probiotic |
| keywords[0].score | 0.833156168460846 |
| keywords[0].display_name | Probiotic |
| keywords[1].id | https://openalex.org/keywords/randomized-controlled-trial |
| keywords[1].score | 0.6548352241516113 |
| keywords[1].display_name | Randomized controlled trial |
| keywords[2].id | https://openalex.org/keywords/ecosystem |
| keywords[2].score | 0.42585426568984985 |
| keywords[2].display_name | Ecosystem |
| keywords[3].id | https://openalex.org/keywords/medicine |
| keywords[3].score | 0.4189993739128113 |
| keywords[3].display_name | Medicine |
| keywords[4].id | https://openalex.org/keywords/food-science |
| keywords[4].score | 0.3578764796257019 |
| keywords[4].display_name | Food science |
| keywords[5].id | https://openalex.org/keywords/internal-medicine |
| keywords[5].score | 0.3255169987678528 |
| keywords[5].display_name | Internal medicine |
| keywords[6].id | https://openalex.org/keywords/biology |
| keywords[6].score | 0.2929752469062805 |
| keywords[6].display_name | Biology |
| keywords[7].id | https://openalex.org/keywords/ecology |
| keywords[7].score | 0.18297645449638367 |
| keywords[7].display_name | Ecology |
| keywords[8].id | https://openalex.org/keywords/bacteria |
| keywords[8].score | 0.10826835036277771 |
| keywords[8].display_name | Bacteria |
| language | en |
| locations[0].id | doi:10.3389/froh.2022.825017 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210201735 |
| locations[0].source.issn | 2673-4842 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2673-4842 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Oral Health |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Oral Health |
| locations[0].landing_page_url | https://doi.org/10.3389/froh.2022.825017 |
| locations[1].id | pmid:35434705 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in oral health |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35434705 |
| locations[2].id | pmh:vu:oai:research.vu.nl:publications/0cfcdf65-b257-41ad-b7e8-00e7e32dadce |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401843 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Data Archiving and Networked Services (DANS) |
| locations[2].source.host_organization | https://openalex.org/I1322597698 |
| locations[2].source.host_organization_name | Royal Netherlands Academy of Arts and Sciences |
| locations[2].source.host_organization_lineage | https://openalex.org/I1322597698 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | info:eu-repo/semantics/article |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Frontiers in oral health |
| locations[2].landing_page_url | https://research.vu.nl/en/publications/0cfcdf65-b257-41ad-b7e8-00e7e32dadce |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:9007728 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Front Oral Health |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9007728 |
| locations[4].id | pmh:oai:doaj.org/article:c7c6a9bb482c44468c4c8a3b484e974b |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].source.host_organization_lineage | |
| locations[4].license | cc-by-sa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Frontiers in Oral Health, Vol 3 (2022) |
| locations[4].landing_page_url | https://doaj.org/article/c7c6a9bb482c44468c4c8a3b484e974b |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5089386909 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4049-2914 |
| authorships[0].author.display_name | C.M.C. Volgenant |
| authorships[0].countries | NL |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2898155008, https://openalex.org/I865915315, https://openalex.org/I887064364 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[0].institutions[0].id | https://openalex.org/I2898155008 |
| authorships[0].institutions[0].ror | https://ror.org/04x5wnb75 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I2898155008 |
| authorships[0].institutions[0].country_code | NL |
| authorships[0].institutions[0].display_name | Academic Center for Dentistry Amsterdam |
| authorships[0].institutions[1].id | https://openalex.org/I887064364 |
| authorships[0].institutions[1].ror | https://ror.org/04dkp9463 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I887064364 |
| authorships[0].institutions[1].country_code | NL |
| authorships[0].institutions[1].display_name | University of Amsterdam |
| authorships[0].institutions[2].id | https://openalex.org/I865915315 |
| authorships[0].institutions[2].ror | https://ror.org/008xxew50 |
| authorships[0].institutions[2].type | education |
| authorships[0].institutions[2].lineage | https://openalex.org/I865915315 |
| authorships[0].institutions[2].country_code | NL |
| authorships[0].institutions[2].display_name | Vrije Universiteit Amsterdam |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Catherine M. C. Volgenant |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[1].author.id | https://openalex.org/A5039132143 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-6407-3714 |
| authorships[1].author.display_name | Suzette V. van der Waal |
| authorships[1].countries | NL |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2898155008, https://openalex.org/I865915315, https://openalex.org/I887064364 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[1].institutions[0].id | https://openalex.org/I2898155008 |
| authorships[1].institutions[0].ror | https://ror.org/04x5wnb75 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I2898155008 |
| authorships[1].institutions[0].country_code | NL |
| authorships[1].institutions[0].display_name | Academic Center for Dentistry Amsterdam |
| authorships[1].institutions[1].id | https://openalex.org/I887064364 |
| authorships[1].institutions[1].ror | https://ror.org/04dkp9463 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I887064364 |
| authorships[1].institutions[1].country_code | NL |
| authorships[1].institutions[1].display_name | University of Amsterdam |
| authorships[1].institutions[2].id | https://openalex.org/I865915315 |
| authorships[1].institutions[2].ror | https://ror.org/008xxew50 |
| authorships[1].institutions[2].type | education |
| authorships[1].institutions[2].lineage | https://openalex.org/I865915315 |
| authorships[1].institutions[2].country_code | NL |
| authorships[1].institutions[2].display_name | Vrije Universiteit Amsterdam |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Suzette V. van der Waal |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[2].author.id | https://openalex.org/A5074330888 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-1155-1989 |
| authorships[2].author.display_name | Bernd W. Brandt |
| authorships[2].countries | NL |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2898155008, https://openalex.org/I865915315, https://openalex.org/I887064364 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[2].institutions[0].id | https://openalex.org/I2898155008 |
| authorships[2].institutions[0].ror | https://ror.org/04x5wnb75 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I2898155008 |
| authorships[2].institutions[0].country_code | NL |
| authorships[2].institutions[0].display_name | Academic Center for Dentistry Amsterdam |
| authorships[2].institutions[1].id | https://openalex.org/I887064364 |
| authorships[2].institutions[1].ror | https://ror.org/04dkp9463 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I887064364 |
| authorships[2].institutions[1].country_code | NL |
| authorships[2].institutions[1].display_name | University of Amsterdam |
| authorships[2].institutions[2].id | https://openalex.org/I865915315 |
| authorships[2].institutions[2].ror | https://ror.org/008xxew50 |
| authorships[2].institutions[2].type | education |
| authorships[2].institutions[2].lineage | https://openalex.org/I865915315 |
| authorships[2].institutions[2].country_code | NL |
| authorships[2].institutions[2].display_name | Vrije Universiteit Amsterdam |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Bernd W. Brandt |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[3].author.id | https://openalex.org/A5043832883 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-4746-4104 |
| authorships[3].author.display_name | M.J. Buijs |
| authorships[3].countries | NL |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2898155008, https://openalex.org/I865915315, https://openalex.org/I887064364 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[3].institutions[0].id | https://openalex.org/I2898155008 |
| authorships[3].institutions[0].ror | https://ror.org/04x5wnb75 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I2898155008 |
| authorships[3].institutions[0].country_code | NL |
| authorships[3].institutions[0].display_name | Academic Center for Dentistry Amsterdam |
| authorships[3].institutions[1].id | https://openalex.org/I887064364 |
| authorships[3].institutions[1].ror | https://ror.org/04dkp9463 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I887064364 |
| authorships[3].institutions[1].country_code | NL |
| authorships[3].institutions[1].display_name | University of Amsterdam |
| authorships[3].institutions[2].id | https://openalex.org/I865915315 |
| authorships[3].institutions[2].ror | https://ror.org/008xxew50 |
| authorships[3].institutions[2].type | education |
| authorships[3].institutions[2].lineage | https://openalex.org/I865915315 |
| authorships[3].institutions[2].country_code | NL |
| authorships[3].institutions[2].display_name | Vrije Universiteit Amsterdam |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Mark J. Buijs |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[4].author.id | https://openalex.org/A5017222430 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-6844-4682 |
| authorships[4].author.display_name | Monique H. van der Veen |
| authorships[4].countries | NL |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2898155008, https://openalex.org/I865915315, https://openalex.org/I887064364 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[4].institutions[0].id | https://openalex.org/I2898155008 |
| authorships[4].institutions[0].ror | https://ror.org/04x5wnb75 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I2898155008 |
| authorships[4].institutions[0].country_code | NL |
| authorships[4].institutions[0].display_name | Academic Center for Dentistry Amsterdam |
| authorships[4].institutions[1].id | https://openalex.org/I887064364 |
| authorships[4].institutions[1].ror | https://ror.org/04dkp9463 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I887064364 |
| authorships[4].institutions[1].country_code | NL |
| authorships[4].institutions[1].display_name | University of Amsterdam |
| authorships[4].institutions[2].id | https://openalex.org/I865915315 |
| authorships[4].institutions[2].ror | https://ror.org/008xxew50 |
| authorships[4].institutions[2].type | education |
| authorships[4].institutions[2].lineage | https://openalex.org/I865915315 |
| authorships[4].institutions[2].country_code | NL |
| authorships[4].institutions[2].display_name | Vrije Universiteit Amsterdam |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Monique H. van der Veen |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[5].author.id | https://openalex.org/A5062701360 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-6708-6836 |
| authorships[5].author.display_name | NAM Rosema |
| authorships[5].countries | NL |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2898155008, https://openalex.org/I865915315, https://openalex.org/I887064364 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Periodontology, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[5].institutions[0].id | https://openalex.org/I2898155008 |
| authorships[5].institutions[0].ror | https://ror.org/04x5wnb75 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I2898155008 |
| authorships[5].institutions[0].country_code | NL |
| authorships[5].institutions[0].display_name | Academic Center for Dentistry Amsterdam |
| authorships[5].institutions[1].id | https://openalex.org/I887064364 |
| authorships[5].institutions[1].ror | https://ror.org/04dkp9463 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I887064364 |
| authorships[5].institutions[1].country_code | NL |
| authorships[5].institutions[1].display_name | University of Amsterdam |
| authorships[5].institutions[2].id | https://openalex.org/I865915315 |
| authorships[5].institutions[2].ror | https://ror.org/008xxew50 |
| authorships[5].institutions[2].type | education |
| authorships[5].institutions[2].lineage | https://openalex.org/I865915315 |
| authorships[5].institutions[2].country_code | NL |
| authorships[5].institutions[2].display_name | Vrije Universiteit Amsterdam |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | N. A. M. Rosema |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Periodontology, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[6].author.id | https://openalex.org/A5035925368 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-9261-6771 |
| authorships[6].author.display_name | Bernd L. Fiebich |
| authorships[6].affiliations[0].raw_affiliation_string | VivaCell Biotechnology GmbH, Denzlingen, Germany |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Bernd L. Fiebich |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | VivaCell Biotechnology GmbH, Denzlingen, Germany |
| authorships[7].author.id | https://openalex.org/A5103476785 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Thorsten Rose |
| authorships[7].affiliations[0].raw_affiliation_string | VivaCell Biotechnology GmbH, Denzlingen, Germany |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Thorsten Rose |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | VivaCell Biotechnology GmbH, Denzlingen, Germany |
| authorships[8].author.id | https://openalex.org/A5073628801 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Tim Schmitter |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I869874271 |
| authorships[8].affiliations[0].raw_affiliation_string | Symrise AG, Holzminden, Germany |
| authorships[8].institutions[0].id | https://openalex.org/I869874271 |
| authorships[8].institutions[0].ror | https://ror.org/023yqa482 |
| authorships[8].institutions[0].type | company |
| authorships[8].institutions[0].lineage | https://openalex.org/I869874271 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | Symrise (Germany) |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Tim Schmitter |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Symrise AG, Holzminden, Germany |
| authorships[9].author.id | https://openalex.org/A5054155676 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Max Gajfulin |
| authorships[9].countries | DE |
| authorships[9].affiliations[0].raw_affiliation_string | Spindiag GmbH, Freiburg im Breisgau, Germany |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I869874271 |
| authorships[9].affiliations[1].raw_affiliation_string | Symrise AG, Holzminden, Germany |
| authorships[9].institutions[0].id | https://openalex.org/I869874271 |
| authorships[9].institutions[0].ror | https://ror.org/023yqa482 |
| authorships[9].institutions[0].type | company |
| authorships[9].institutions[0].lineage | https://openalex.org/I869874271 |
| authorships[9].institutions[0].country_code | DE |
| authorships[9].institutions[0].display_name | Symrise (Germany) |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Max Gajfulin |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Spindiag GmbH, Freiburg im Breisgau, Germany, Symrise AG, Holzminden, Germany |
| authorships[10].author.id | https://openalex.org/A5110563265 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Wim Crielaard |
| authorships[10].countries | NL |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I2898155008, https://openalex.org/I865915315, https://openalex.org/I887064364 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[10].institutions[0].id | https://openalex.org/I2898155008 |
| authorships[10].institutions[0].ror | https://ror.org/04x5wnb75 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I2898155008 |
| authorships[10].institutions[0].country_code | NL |
| authorships[10].institutions[0].display_name | Academic Center for Dentistry Amsterdam |
| authorships[10].institutions[1].id | https://openalex.org/I887064364 |
| authorships[10].institutions[1].ror | https://ror.org/04dkp9463 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I887064364 |
| authorships[10].institutions[1].country_code | NL |
| authorships[10].institutions[1].display_name | University of Amsterdam |
| authorships[10].institutions[2].id | https://openalex.org/I865915315 |
| authorships[10].institutions[2].ror | https://ror.org/008xxew50 |
| authorships[10].institutions[2].type | education |
| authorships[10].institutions[2].lineage | https://openalex.org/I865915315 |
| authorships[10].institutions[2].country_code | NL |
| authorships[10].institutions[2].display_name | Vrije Universiteit Amsterdam |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Wim Crielaard |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[11].author.id | https://openalex.org/A5075911351 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-1432-6194 |
| authorships[11].author.display_name | Egija Zaura |
| authorships[11].countries | NL |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I2898155008, https://openalex.org/I865915315, https://openalex.org/I887064364 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| authorships[11].institutions[0].id | https://openalex.org/I2898155008 |
| authorships[11].institutions[0].ror | https://ror.org/04x5wnb75 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I2898155008 |
| authorships[11].institutions[0].country_code | NL |
| authorships[11].institutions[0].display_name | Academic Center for Dentistry Amsterdam |
| authorships[11].institutions[1].id | https://openalex.org/I887064364 |
| authorships[11].institutions[1].ror | https://ror.org/04dkp9463 |
| authorships[11].institutions[1].type | education |
| authorships[11].institutions[1].lineage | https://openalex.org/I887064364 |
| authorships[11].institutions[1].country_code | NL |
| authorships[11].institutions[1].display_name | University of Amsterdam |
| authorships[11].institutions[2].id | https://openalex.org/I865915315 |
| authorships[11].institutions[2].ror | https://ror.org/008xxew50 |
| authorships[11].institutions[2].type | education |
| authorships[11].institutions[2].lineage | https://openalex.org/I865915315 |
| authorships[11].institutions[2].country_code | NL |
| authorships[11].institutions[2].display_name | Vrije Universiteit Amsterdam |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Egija Zaura |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, Netherlands |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.3389/froh.2022.825017 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | The Evaluation of the Effects of Two Probiotic Strains on the Oral Ecosystem: A Randomized Clinical Trial |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10257 |
| primary_topic.field.id | https://openalex.org/fields/35 |
| primary_topic.field.display_name | Dentistry |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/3506 |
| primary_topic.subfield.display_name | Periodontics |
| primary_topic.display_name | Oral microbiology and periodontitis research |
| related_works | https://openalex.org/W2984222266, https://openalex.org/W2468853327, https://openalex.org/W3174709511, https://openalex.org/W2767503609, https://openalex.org/W2033507994, https://openalex.org/W2065096163, https://openalex.org/W2783640880, https://openalex.org/W1694758928, https://openalex.org/W4281781496, https://openalex.org/W2355769538 |
| cited_by_count | 7 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 6 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3389/froh.2022.825017 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210201735 |
| best_oa_location.source.issn | 2673-4842 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2673-4842 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Oral Health |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Oral Health |
| best_oa_location.landing_page_url | https://doi.org/10.3389/froh.2022.825017 |
| primary_location.id | doi:10.3389/froh.2022.825017 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210201735 |
| primary_location.source.issn | 2673-4842 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2673-4842 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Oral Health |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Oral Health |
| primary_location.landing_page_url | https://doi.org/10.3389/froh.2022.825017 |
| publication_date | 2022-03-30 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2948786533, https://openalex.org/W2296180810, https://openalex.org/W2215975960, https://openalex.org/W5656748, https://openalex.org/W2054068403, https://openalex.org/W2008641076, https://openalex.org/W2143474762, https://openalex.org/W6637015135, https://openalex.org/W2740201683, https://openalex.org/W2882994713, https://openalex.org/W2087484885, https://openalex.org/W2063185787, https://openalex.org/W2282442395, https://openalex.org/W2323579598, https://openalex.org/W2107228383, https://openalex.org/W2117522399, https://openalex.org/W6600217670, https://openalex.org/W2084775960, https://openalex.org/W1971119835, https://openalex.org/W1980620743, https://openalex.org/W6606168237, https://openalex.org/W1930625272, https://openalex.org/W2117457769, https://openalex.org/W152315577, https://openalex.org/W2118853478, https://openalex.org/W2115149585, https://openalex.org/W1663709584, https://openalex.org/W2990480760, https://openalex.org/W2124351063, https://openalex.org/W2162667876, https://openalex.org/W2538509698, https://openalex.org/W2115699469, https://openalex.org/W2072970694, https://openalex.org/W2152885278, https://openalex.org/W2125249373, https://openalex.org/W1963710004, https://openalex.org/W2577168313, https://openalex.org/W2062678675, https://openalex.org/W2165799971, https://openalex.org/W2765140306, https://openalex.org/W3191059502, https://openalex.org/W3108065040, https://openalex.org/W1984982865, https://openalex.org/W2972628234, https://openalex.org/W4230702621, https://openalex.org/W4241771140 |
| referenced_works_count | 46 |
| abstract_inverted_index.( | 236 |
| abstract_inverted_index., | 169 |
| abstract_inverted_index.2 | 194 |
| abstract_inverted_index.3 | 157 |
| abstract_inverted_index.= | 238 |
| abstract_inverted_index.M | 18 |
| abstract_inverted_index.a | 65, 108, 116, 127, 177 |
| abstract_inverted_index.p | 237 |
| abstract_inverted_index.In | 1 |
| abstract_inverted_index.L. | 165, 167, 270, 279, 289, 292 |
| abstract_inverted_index.an | 27 |
| abstract_inverted_index.by | 107 |
| abstract_inverted_index.in | 201, 214, 232, 252, 266 |
| abstract_inverted_index.no | 199 |
| abstract_inverted_index.of | 9, 40, 44, 78, 97, 142, 190, 305 |
| abstract_inverted_index.on | 54, 59, 82 |
| abstract_inverted_index.or | 170, 291 |
| abstract_inverted_index.to | 35, 74, 153, 185, 220, 311 |
| abstract_inverted_index.we | 5 |
| abstract_inverted_index.117 | 143 |
| abstract_inverted_index.DNA | 265 |
| abstract_inverted_index.The | 31, 70, 137, 242, 283 |
| abstract_inverted_index.and | 20, 92, 94, 99, 115, 269 |
| abstract_inverted_index.any | 188 |
| abstract_inverted_index.did | 295 |
| abstract_inverted_index.for | 193, 298, 301 |
| abstract_inverted_index.old | 147 |
| abstract_inverted_index.one | 43, 155 |
| abstract_inverted_index.the | 2, 7, 38, 45, 55, 76, 79, 95, 103, 181, 202, 208, 217, 221, 230, 233, 255, 278, 288, 302, 306, 312 |
| abstract_inverted_index.two | 10, 46, 243, 284 |
| abstract_inverted_index.use | 154 |
| abstract_inverted_index.was | 34, 126 |
| abstract_inverted_index.(DSM | 24 |
| abstract_inverted_index.BOMP | 62 |
| abstract_inverted_index.Both | 259 |
| abstract_inverted_index.This | 121 |
| abstract_inverted_index.each | 161 |
| abstract_inverted_index.form | 189 |
| abstract_inverted_index.from | 112, 187, 216, 226 |
| abstract_inverted_index.full | 138 |
| abstract_inverted_index.host | 307 |
| abstract_inverted_index.oral | 47, 113, 191, 303, 313 |
| abstract_inverted_index.show | 296 |
| abstract_inverted_index.test | 80, 222, 244, 260 |
| abstract_inverted_index.than | 229, 277 |
| abstract_inverted_index.were | 73, 151, 183, 198 |
| abstract_inverted_index.with | 51, 133, 287 |
| abstract_inverted_index.(BOMP | 205 |
| abstract_inverted_index.(MGI) | 213 |
| abstract_inverted_index.After | 176 |
| abstract_inverted_index.GOS42 | 23 |
| abstract_inverted_index.MGI), | 88 |
| abstract_inverted_index.There | 197 |
| abstract_inverted_index.after | 64, 102, 160 |
| abstract_inverted_index.among | 207 |
| abstract_inverted_index.daily | 159 |
| abstract_inverted_index.group | 235 |
| abstract_inverted_index.human | 148 |
| abstract_inverted_index.meal, | 162 |
| abstract_inverted_index.study | 125, 139 |
| abstract_inverted_index.three | 134 |
| abstract_inverted_index.times | 158 |
| abstract_inverted_index.trial | 132 |
| abstract_inverted_index.years | 146 |
| abstract_inverted_index.(CCTCC | 17 |
| abstract_inverted_index.0.021, | 239 |
| abstract_inverted_index.2-week | 178 |
| abstract_inverted_index.IL-1ß | 249 |
| abstract_inverted_index.Index; | 87 |
| abstract_inverted_index.assess | 75 |
| abstract_inverted_index.better | 225 |
| abstract_inverted_index.dental | 89 |
| abstract_inverted_index.during | 26, 254, 308 |
| abstract_inverted_index.either | 164 |
| abstract_inverted_index.groups | 218 |
| abstract_inverted_index.health | 84, 212, 304 |
| abstract_inverted_index.period | 110 |
| abstract_inverted_index.phase, | 105 |
| abstract_inverted_index.phase. | 119 |
| abstract_inverted_index.plaque | 90 |
| abstract_inverted_index.showed | 273 |
| abstract_inverted_index.strain | 272 |
| abstract_inverted_index.study, | 4 |
| abstract_inverted_index.tested | 285 |
| abstract_inverted_index.tongue | 267 |
| abstract_inverted_index.weeks. | 195 |
| abstract_inverted_index.18–55 | 145 |
| abstract_inverted_index.32131), | 25 |
| abstract_inverted_index.ANOVA). | 241 |
| abstract_inverted_index.Methods | 120 |
| abstract_inverted_index.Results | 196 |
| abstract_inverted_index.aspects | 101 |
| abstract_inverted_index.change) | 63, 206 |
| abstract_inverted_index.current | 3 |
| abstract_inverted_index.effects | 77, 300 |
| abstract_inverted_index.exposed | 219 |
| abstract_inverted_index.group). | 175 |
| abstract_inverted_index.groups. | 136, 209 |
| abstract_inverted_index.healthy | 144 |
| abstract_inverted_index.hygiene | 114, 192 |
| abstract_inverted_index.one-way | 240 |
| abstract_inverted_index.outcome | 204 |
| abstract_inverted_index.period, | 180 |
| abstract_inverted_index.period. | 69, 258 |
| abstract_inverted_index.placebo | 52, 234 |
| abstract_inverted_index.primary | 32, 203 |
| abstract_inverted_index.reduced | 263 |
| abstract_inverted_index.refrain | 186 |
| abstract_inverted_index.saliva, | 253 |
| abstract_inverted_index.samples | 268 |
| abstract_inverted_index.strain. | 281 |
| abstract_inverted_index.strains | 261, 294 |
| abstract_inverted_index.wash-in | 104, 179 |
| abstract_inverted_index.without | 172 |
| abstract_inverted_index.(placebo | 174 |
| abstract_inverted_index.2013691) | 19 |
| abstract_inverted_index.Gingival | 86 |
| abstract_inverted_index.However, | 210 |
| abstract_inverted_index.LPc-G110 | 16 |
| abstract_inverted_index.Subjects | 150 |
| abstract_inverted_index.bleeding | 57 |
| abstract_inverted_index.clinical | 131 |
| abstract_inverted_index.compared | 50 |
| abstract_inverted_index.cytokine | 248 |
| abstract_inverted_index.dynamics | 96 |
| abstract_inverted_index.evaluate | 36 |
| abstract_inverted_index.followed | 106 |
| abstract_inverted_index.gingival | 56, 83, 211 |
| abstract_inverted_index.lozenge, | 156 |
| abstract_inverted_index.lozenges | 41, 171, 286 |
| abstract_inverted_index.marginal | 60 |
| abstract_inverted_index.measured | 251 |
| abstract_inverted_index.parallel | 135 |
| abstract_inverted_index.probing; | 61 |
| abstract_inverted_index.products | 81, 223, 245 |
| abstract_inverted_index.strains, | 13, 49 |
| abstract_inverted_index.stronger | 274 |
| abstract_inverted_index.subjects | 182 |
| abstract_inverted_index.two-week | 66, 109, 117 |
| abstract_inverted_index.wash-out | 118 |
| abstract_inverted_index.(Modified | 85 |
| abstract_inverted_index.(bleeding | 58 |
| abstract_inverted_index.bacterial | 264 |
| abstract_inverted_index.challenge | 123 |
| abstract_inverted_index.consisted | 141 |
| abstract_inverted_index.evaluated | 6 |
| abstract_inverted_index.inhibited | 246 |
| abstract_inverted_index.lozenges, | 53 |
| abstract_inverted_index.objective | 33 |
| abstract_inverted_index.paracasei | 15, 168, 271, 290 |
| abstract_inverted_index.plantarum | 22, 280, 293 |
| abstract_inverted_index.potential | 276, 297 |
| abstract_inverted_index.probiotic | 12, 48 |
| abstract_inverted_index.recovered | 224 |
| abstract_inverted_index.requested | 184 |
| abstract_inverted_index.secondary | 71 |
| abstract_inverted_index.beneficial | 299 |
| abstract_inverted_index.challenge. | 30 |
| abstract_inverted_index.clinically | 37 |
| abstract_inverted_index.containing | 42, 163 |
| abstract_inverted_index.ecosystem. | 314 |
| abstract_inverted_index.gingivitis | 29, 68, 228, 257, 310 |
| abstract_inverted_index.instructed | 152 |
| abstract_inverted_index.objectives | 72 |
| abstract_inverted_index.plantarum, | 166 |
| abstract_inverted_index.population | 140 |
| abstract_inverted_index.probiotics | 173 |
| abstract_inverted_index.randomized | 129 |
| abstract_inverted_index.refraining | 111 |
| abstract_inverted_index.Conclusions | 282 |
| abstract_inverted_index.differences | 200 |
| abstract_inverted_index.individuals | 215, 231 |
| abstract_inverted_index.production, | 250 |
| abstract_inverted_index.volunteers. | 149 |
| abstract_inverted_index.Introduction | 0 |
| abstract_inverted_index.accumulation | 91 |
| abstract_inverted_index.experimental | 28, 67, 227, 256, 309 |
| abstract_inverted_index.intervention | 124 |
| abstract_inverted_index.triple-blind | 128 |
| abstract_inverted_index.well-defined | 11 |
| abstract_inverted_index.Lactobacillus | 14, 21 |
| abstract_inverted_index.effectiveness | 8, 39 |
| abstract_inverted_index.fluorescence, | 93 |
| abstract_inverted_index.immunological | 98 |
| abstract_inverted_index.significantly | 262 |
| abstract_inverted_index.single-center | 122 |
| abstract_inverted_index.microbiological | 100 |
| abstract_inverted_index.pro-inflammatory | 247 |
| abstract_inverted_index.placebo-controlled | 130 |
| abstract_inverted_index.microbiome-modulating | 275 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5089386909 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I2898155008, https://openalex.org/I865915315, https://openalex.org/I887064364 |
| citation_normalized_percentile.value | 0.75232793 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |