The Expression and Clinical Outcome of pCHK2-Thr68 and pCDC25C-Ser216 in Breast Cancer Article Swipe
Huayong Jiang
,
Bin Wang
,
Fuli Zhang
,
Yuanyu Qian
,
Chia‐Chen Chuang
,
Mingzhen Ying
,
Yajie Wang
,
Li Zuo
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.3390/ijms17111803
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.3390/ijms17111803
Checkpoint kinase 2 (CHK2) and cell division cycle 25C (CDC25C) are two proteins involved in the DNA damage response pathway, playing essential roles in maintaining genome integrity. As one of the major hallmarks of abnormal cellular division, genomic instability occurs in most cancers. In this study, we identified the functional expression of pCHK2-Thr68 and pCDC25C-Ser216 in breast cancer, as well as its association with breast cancer survival. Tissue microarray analysis using immunohistochemistry was constructed to identify the expression of pCHK2-Thr68 and pCDC25C-Ser216 in 292 female breast cancer patients. The relationship among protein expression, clinicopathological factors (e.g., human epidermal growth factor receptor 2 (HER 2), tumor size, tumor-node-metastasis (TNM) classification), and overall survival of the breast cancer tissues were analyzed using Pearson’s χ-square (χ2) test, Fisher’s exact test, multivariate logistic regression and Kaplan–Meier survival analysis. Significantly higher expressions of pCHK2-Thr68 and pCDC25C-Ser216 were observed in the nucleus of the breast cancer cells compared to the paracancerous tissue (pCHK2-Thr68, 20.38% vs. 0%; pCDC25C-Ser216, 82.26% vs. 24.24%). The expression of pCHK2-Thr68 and pCDC25C-Ser216 in breast cancer showed a positive linear correlation (p = 0.026). High expression of pCHK2-Thr68 was associated with decreased patient survival (p = 0.001), but was not an independent prognostic factor. Our results suggest that pCHK2-Thr68 and pCDC25C-Ser216 play important roles in breast cancer and may be potential treatment targets.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms17111803
- https://www.mdpi.com/1422-0067/17/11/1803/pdf?version=1477878229
- OA Status
- gold
- Cited By
- 7
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2542479456
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2542479456Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms17111803Digital Object Identifier
- Title
-
The Expression and Clinical Outcome of pCHK2-Thr68 and pCDC25C-Ser216 in Breast CancerWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-10-28Full publication date if available
- Authors
-
Huayong Jiang, Bin Wang, Fuli Zhang, Yuanyu Qian, Chia‐Chen Chuang, Mingzhen Ying, Yajie Wang, Li ZuoList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms17111803Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/17/11/1803/pdf?version=1477878229Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/17/11/1803/pdf?version=1477878229Direct OA link when available
- Concepts
-
Breast cancer, Oncology, Cancer, Medicine, Internal medicine, Outcome (game theory), Gynecology, Mathematics, Mathematical economicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2023: 1, 2022: 1, 2021: 1, 2019: 1Per-year citation counts (last 5 years)
- References (count)
-
42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2542479456 |
|---|---|
| doi | https://doi.org/10.3390/ijms17111803 |
| ids.doi | https://doi.org/10.3390/ijms17111803 |
| ids.mag | 2542479456 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/27801830 |
| ids.openalex | https://openalex.org/W2542479456 |
| fwci | 0.34665233 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000328 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Adult |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000368 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Aged |
| mesh[2].qualifier_ui | Q000096 |
| mesh[2].descriptor_ui | D014408 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | biosynthesis |
| mesh[2].descriptor_name | Biomarkers, Tumor |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D014408 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | Biomarkers, Tumor |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D001943 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Breast Neoplasms |
| mesh[5].qualifier_ui | Q000473 |
| mesh[5].descriptor_ui | D001943 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | pathology |
| mesh[5].descriptor_name | Breast Neoplasms |
| mesh[6].qualifier_ui | Q000096 |
| mesh[6].descriptor_ui | D064447 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | biosynthesis |
| mesh[6].descriptor_name | Checkpoint Kinase 2 |
| mesh[7].qualifier_ui | Q000235 |
| mesh[7].descriptor_ui | D064447 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | genetics |
| mesh[7].descriptor_name | Checkpoint Kinase 2 |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D004249 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | DNA Damage |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D005260 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Female |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D015972 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Gene Expression Regulation, Neoplastic |
| mesh[11].qualifier_ui | Q000235 |
| mesh[11].descriptor_ui | D042822 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | genetics |
| mesh[11].descriptor_name | Genomic Instability |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D006801 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Humans |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D053208 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Kaplan-Meier Estimate |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D008207 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | Lymphatic Metastasis |
| mesh[15].qualifier_ui | Q000473 |
| mesh[15].descriptor_ui | D008207 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pathology |
| mesh[15].descriptor_name | Lymphatic Metastasis |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D046228 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Microarray Analysis |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D008875 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Middle Aged |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D009367 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Neoplasm Staging |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D011379 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Prognosis |
| mesh[20].qualifier_ui | Q000235 |
| mesh[20].descriptor_ui | D018719 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | genetics |
| mesh[20].descriptor_name | Receptor, ErbB-2 |
| mesh[21].qualifier_ui | Q000096 |
| mesh[21].descriptor_ui | D020687 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | biosynthesis |
| mesh[21].descriptor_name | cdc25 Phosphatases |
| mesh[22].qualifier_ui | Q000235 |
| mesh[22].descriptor_ui | D020687 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | genetics |
| mesh[22].descriptor_name | cdc25 Phosphatases |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D000328 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Adult |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D000368 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Aged |
| mesh[25].qualifier_ui | Q000096 |
| mesh[25].descriptor_ui | D014408 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | biosynthesis |
| mesh[25].descriptor_name | Biomarkers, Tumor |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D014408 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | Biomarkers, Tumor |
| mesh[27].qualifier_ui | Q000235 |
| mesh[27].descriptor_ui | D001943 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | genetics |
| mesh[27].descriptor_name | Breast Neoplasms |
| mesh[28].qualifier_ui | Q000473 |
| mesh[28].descriptor_ui | D001943 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | pathology |
| mesh[28].descriptor_name | Breast Neoplasms |
| mesh[29].qualifier_ui | Q000096 |
| mesh[29].descriptor_ui | D064447 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | biosynthesis |
| mesh[29].descriptor_name | Checkpoint Kinase 2 |
| mesh[30].qualifier_ui | Q000235 |
| mesh[30].descriptor_ui | D064447 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | genetics |
| mesh[30].descriptor_name | Checkpoint Kinase 2 |
| mesh[31].qualifier_ui | Q000235 |
| mesh[31].descriptor_ui | D004249 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | genetics |
| mesh[31].descriptor_name | DNA Damage |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D005260 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Female |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D015972 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Gene Expression Regulation, Neoplastic |
| mesh[34].qualifier_ui | Q000235 |
| mesh[34].descriptor_ui | D042822 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | genetics |
| mesh[34].descriptor_name | Genomic Instability |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D006801 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Humans |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D053208 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Kaplan-Meier Estimate |
| mesh[37].qualifier_ui | Q000235 |
| mesh[37].descriptor_ui | D008207 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | genetics |
| mesh[37].descriptor_name | Lymphatic Metastasis |
| mesh[38].qualifier_ui | Q000473 |
| mesh[38].descriptor_ui | D008207 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | pathology |
| mesh[38].descriptor_name | Lymphatic Metastasis |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D046228 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Microarray Analysis |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D008875 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Middle Aged |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D009367 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Neoplasm Staging |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D011379 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Prognosis |
| mesh[43].qualifier_ui | Q000235 |
| mesh[43].descriptor_ui | D018719 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | genetics |
| mesh[43].descriptor_name | Receptor, ErbB-2 |
| mesh[44].qualifier_ui | Q000096 |
| mesh[44].descriptor_ui | D020687 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | biosynthesis |
| mesh[44].descriptor_name | cdc25 Phosphatases |
| mesh[45].qualifier_ui | Q000235 |
| mesh[45].descriptor_ui | D020687 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | genetics |
| mesh[45].descriptor_name | cdc25 Phosphatases |
| type | article |
| title | The Expression and Clinical Outcome of pCHK2-Thr68 and pCDC25C-Ser216 in Breast Cancer |
| awards[0].id | https://openalex.org/G940298579 |
| awards[0].funder_id | https://openalex.org/F4320321001 |
| awards[0].display_name | |
| awards[0].funder_award_id | NSFC81102010 |
| awards[0].funder_display_name | National Natural Science Foundation of China |
| awards[1].id | https://openalex.org/G8623054203 |
| awards[1].funder_id | https://openalex.org/F4320325435 |
| awards[1].display_name | |
| awards[1].funder_award_id | 1255 Discipline Construction Projects |
| awards[1].funder_display_name | Changhai Hospital of Shanghai |
| awards[2].id | https://openalex.org/G8981486649 |
| awards[2].funder_id | https://openalex.org/F4320321001 |
| awards[2].display_name | |
| awards[2].funder_award_id | NSFC81472479 |
| awards[2].funder_display_name | National Natural Science Foundation of China |
| biblio.issue | 11 |
| biblio.volume | 17 |
| biblio.last_page | 1803 |
| biblio.first_page | 1803 |
| grants[0].funder | https://openalex.org/F4320321001 |
| grants[0].award_id | NSFC81102010 |
| grants[0].funder_display_name | National Natural Science Foundation of China |
| grants[1].funder | https://openalex.org/F4320321001 |
| grants[1].award_id | NSFC81472479 |
| grants[1].funder_display_name | National Natural Science Foundation of China |
| grants[2].funder | https://openalex.org/F4320325435 |
| grants[2].award_id | 1255 Discipline Construction Projects |
| grants[2].funder_display_name | Changhai Hospital of Shanghai |
| topics[0].id | https://openalex.org/T10123 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | DNA Repair Mechanisms |
| topics[1].id | https://openalex.org/T11914 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9995999932289124 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2730 |
| topics[1].subfield.display_name | Oncology |
| topics[1].display_name | PARP inhibition in cancer therapy |
| topics[2].id | https://openalex.org/T10583 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9990000128746033 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2730 |
| topics[2].subfield.display_name | Oncology |
| topics[2].display_name | Cancer-related Molecular Pathways |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320325435 |
| funders[1].ror | https://ror.org/02bjs0p66 |
| funders[1].display_name | Changhai Hospital of Shanghai |
| is_xpac | False |
| apc_list.value | 2300 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2300 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2490 |
| concepts[0].id | https://openalex.org/C530470458 |
| concepts[0].level | 3 |
| concepts[0].score | 0.6692250967025757 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q128581 |
| concepts[0].display_name | Breast cancer |
| concepts[1].id | https://openalex.org/C143998085 |
| concepts[1].level | 1 |
| concepts[1].score | 0.5074476599693298 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[1].display_name | Oncology |
| concepts[2].id | https://openalex.org/C121608353 |
| concepts[2].level | 2 |
| concepts[2].score | 0.4848810136318207 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[2].display_name | Cancer |
| concepts[3].id | https://openalex.org/C71924100 |
| concepts[3].level | 0 |
| concepts[3].score | 0.4699400067329407 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[3].display_name | Medicine |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.43760615587234497 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| concepts[5].id | https://openalex.org/C148220186 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4213806986808777 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7111912 |
| concepts[5].display_name | Outcome (game theory) |
| concepts[6].id | https://openalex.org/C29456083 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3402864933013916 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1221899 |
| concepts[6].display_name | Gynecology |
| concepts[7].id | https://openalex.org/C33923547 |
| concepts[7].level | 0 |
| concepts[7].score | 0.10353890061378479 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q395 |
| concepts[7].display_name | Mathematics |
| concepts[8].id | https://openalex.org/C144237770 |
| concepts[8].level | 1 |
| concepts[8].score | 0.0 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q747534 |
| concepts[8].display_name | Mathematical economics |
| keywords[0].id | https://openalex.org/keywords/breast-cancer |
| keywords[0].score | 0.6692250967025757 |
| keywords[0].display_name | Breast cancer |
| keywords[1].id | https://openalex.org/keywords/oncology |
| keywords[1].score | 0.5074476599693298 |
| keywords[1].display_name | Oncology |
| keywords[2].id | https://openalex.org/keywords/cancer |
| keywords[2].score | 0.4848810136318207 |
| keywords[2].display_name | Cancer |
| keywords[3].id | https://openalex.org/keywords/medicine |
| keywords[3].score | 0.4699400067329407 |
| keywords[3].display_name | Medicine |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.43760615587234497 |
| keywords[4].display_name | Internal medicine |
| keywords[5].id | https://openalex.org/keywords/outcome |
| keywords[5].score | 0.4213806986808777 |
| keywords[5].display_name | Outcome (game theory) |
| keywords[6].id | https://openalex.org/keywords/gynecology |
| keywords[6].score | 0.3402864933013916 |
| keywords[6].display_name | Gynecology |
| keywords[7].id | https://openalex.org/keywords/mathematics |
| keywords[7].score | 0.10353890061378479 |
| keywords[7].display_name | Mathematics |
| language | en |
| locations[0].id | doi:10.3390/ijms17111803 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S10623703 |
| locations[0].source.issn | 1422-0067, 1661-6596 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1422-0067 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | International Journal of Molecular Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1422-0067/17/11/1803/pdf?version=1477878229 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | International Journal of Molecular Sciences |
| locations[0].landing_page_url | https://doi.org/10.3390/ijms17111803 |
| locations[1].id | pmid:27801830 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | International journal of molecular sciences |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/27801830 |
| locations[2].id | pmh:oai:doaj.org/article:70f901709c224a9898a8c03bf9a30956 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | International Journal of Molecular Sciences, Vol 17, Iss 11, p 1803 (2016) |
| locations[2].landing_page_url | https://doaj.org/article/70f901709c224a9898a8c03bf9a30956 |
| locations[3].id | pmh:oai:mdpi.com:/1422-0067/17/11/1803/ |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400947 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | True |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | MDPI (MDPI AG) |
| locations[3].source.host_organization | https://openalex.org/I4210097602 |
| locations[3].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | International Journal of Molecular Sciences; Volume 17; Issue 11; Pages: 1803 |
| locations[3].landing_page_url | https://dx.doi.org/10.3390/ijms17111803 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:5133804 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | |
| locations[4].landing_page_url | http://doi.org/10.3390/ijms17111803 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5102877396 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4977-300X |
| authorships[0].author.display_name | Huayong Jiang |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Radiation Oncology, PLA Army General Hospital, Beijing 100700, China |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Huayong Jiang |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Radiation Oncology, PLA Army General Hospital, Beijing 100700, China |
| authorships[1].author.id | https://openalex.org/A5100372359 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-4467-4176 |
| authorships[1].author.display_name | Bin Wang |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I177933477, https://openalex.org/I4210115928 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China |
| authorships[1].institutions[0].id | https://openalex.org/I4210115928 |
| authorships[1].institutions[0].ror | https://ror.org/02bjs0p66 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210115928 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Changhai Hospital |
| authorships[1].institutions[1].id | https://openalex.org/I177933477 |
| authorships[1].institutions[1].ror | https://ror.org/04tavpn47 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I177933477 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Second Military Medical University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Bin Wang |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China |
| authorships[2].author.id | https://openalex.org/A5058225779 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-4175-4795 |
| authorships[2].author.display_name | Fuli Zhang |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Radiation Oncology, PLA Army General Hospital, Beijing 100700, China |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Fuli Zhang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Radiation Oncology, PLA Army General Hospital, Beijing 100700, China |
| authorships[3].author.id | https://openalex.org/A5108760558 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Yuanyu Qian |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2802939634 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Emergency, Chinese PLA General Hospital, Beijing 100853, China |
| authorships[3].institutions[0].id | https://openalex.org/I2802939634 |
| authorships[3].institutions[0].ror | https://ror.org/04gw3ra78 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2802939634 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Chinese PLA General Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Yuanyu Qian |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Emergency, Chinese PLA General Hospital, Beijing 100853, China |
| authorships[4].author.id | https://openalex.org/A5002260041 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-4594-5860 |
| authorships[4].author.display_name | Chia‐Chen Chuang |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I52357470 |
| authorships[4].affiliations[0].raw_affiliation_string | Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA |
| authorships[4].institutions[0].id | https://openalex.org/I52357470 |
| authorships[4].institutions[0].ror | https://ror.org/00rs6vg23 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I52357470 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | The Ohio State University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Chia-Chen Chuang |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA |
| authorships[5].author.id | https://openalex.org/A5101289986 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Mingzhen Ying |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I177933477, https://openalex.org/I4210115928 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China |
| authorships[5].institutions[0].id | https://openalex.org/I4210115928 |
| authorships[5].institutions[0].ror | https://ror.org/02bjs0p66 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210115928 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Changhai Hospital |
| authorships[5].institutions[1].id | https://openalex.org/I177933477 |
| authorships[5].institutions[1].ror | https://ror.org/04tavpn47 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I177933477 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | Second Military Medical University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Mingzhen Ying |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China |
| authorships[6].author.id | https://openalex.org/A5100455409 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-5042-0909 |
| authorships[6].author.display_name | Yajie Wang |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I177933477, https://openalex.org/I4210115928 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China |
| authorships[6].institutions[0].id | https://openalex.org/I4210115928 |
| authorships[6].institutions[0].ror | https://ror.org/02bjs0p66 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210115928 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Changhai Hospital |
| authorships[6].institutions[1].id | https://openalex.org/I177933477 |
| authorships[6].institutions[1].ror | https://ror.org/04tavpn47 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I177933477 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Second Military Medical University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Yajie Wang |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Department of Oncology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China |
| authorships[7].author.id | https://openalex.org/A5100723747 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-0553-0994 |
| authorships[7].author.display_name | Li Zuo |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I52357470 |
| authorships[7].affiliations[0].raw_affiliation_string | Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA |
| authorships[7].institutions[0].id | https://openalex.org/I52357470 |
| authorships[7].institutions[0].ror | https://ror.org/00rs6vg23 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I52357470 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | The Ohio State University |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Li Zuo |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Radiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1422-0067/17/11/1803/pdf?version=1477878229 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | The Expression and Clinical Outcome of pCHK2-Thr68 and pCDC25C-Ser216 in Breast Cancer |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10123 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | DNA Repair Mechanisms |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2978999882, https://openalex.org/W3141031773, https://openalex.org/W1595686156, https://openalex.org/W2181392282, https://openalex.org/W2119369480, https://openalex.org/W148937441, https://openalex.org/W2153369162, https://openalex.org/W2989121736, https://openalex.org/W2892677547 |
| cited_by_count | 7 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 1 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 1 |
| counts_by_year[4].year | 2019 |
| counts_by_year[4].cited_by_count | 1 |
| counts_by_year[5].year | 2017 |
| counts_by_year[5].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/ijms17111803 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S10623703 |
| best_oa_location.source.issn | 1422-0067, 1661-6596 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1422-0067 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | International Journal of Molecular Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1422-0067/17/11/1803/pdf?version=1477878229 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | International Journal of Molecular Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.3390/ijms17111803 |
| primary_location.id | doi:10.3390/ijms17111803 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S10623703 |
| primary_location.source.issn | 1422-0067, 1661-6596 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1422-0067 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | International Journal of Molecular Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1422-0067/17/11/1803/pdf?version=1477878229 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | International Journal of Molecular Sciences |
| primary_location.landing_page_url | https://doi.org/10.3390/ijms17111803 |
| publication_date | 2016-10-28 |
| publication_year | 2016 |
| referenced_works | https://openalex.org/W2235523093, https://openalex.org/W2022175865, https://openalex.org/W1538419182, https://openalex.org/W1981587077, https://openalex.org/W2096136751, https://openalex.org/W2013493332, https://openalex.org/W2024667952, https://openalex.org/W2113384830, https://openalex.org/W2062219923, https://openalex.org/W2327472703, https://openalex.org/W2030381529, https://openalex.org/W2075744273, https://openalex.org/W2067237517, https://openalex.org/W2150281555, https://openalex.org/W1966391232, https://openalex.org/W2108979392, https://openalex.org/W2034234512, https://openalex.org/W1985764154, https://openalex.org/W2150964559, https://openalex.org/W2011369725, https://openalex.org/W2118026666, https://openalex.org/W2009628240, https://openalex.org/W2212776653, https://openalex.org/W2070554004, https://openalex.org/W2118528246, https://openalex.org/W2092739165, https://openalex.org/W2166247816, https://openalex.org/W1989059483, https://openalex.org/W2126143290, https://openalex.org/W2028078333, https://openalex.org/W1968193739, https://openalex.org/W2008056664, https://openalex.org/W1997432948, https://openalex.org/W2029304297, https://openalex.org/W2046083330, https://openalex.org/W2043916245, https://openalex.org/W2145248738, https://openalex.org/W1973268287, https://openalex.org/W2032339964, https://openalex.org/W2054576158, https://openalex.org/W2208283866, https://openalex.org/W2037934942 |
| referenced_works_count | 42 |
| abstract_inverted_index.2 | 2, 101 |
| abstract_inverted_index.= | 179, 192 |
| abstract_inverted_index.a | 174 |
| abstract_inverted_index.(p | 178, 191 |
| abstract_inverted_index.As | 27 |
| abstract_inverted_index.In | 43 |
| abstract_inverted_index.an | 197 |
| abstract_inverted_index.as | 58, 60 |
| abstract_inverted_index.be | 216 |
| abstract_inverted_index.in | 14, 23, 40, 55, 82, 143, 170, 211 |
| abstract_inverted_index.of | 29, 33, 51, 78, 112, 137, 146, 166, 183 |
| abstract_inverted_index.to | 74, 152 |
| abstract_inverted_index.we | 46 |
| abstract_inverted_index.0%; | 159 |
| abstract_inverted_index.2), | 103 |
| abstract_inverted_index.25C | 8 |
| abstract_inverted_index.292 | 83 |
| abstract_inverted_index.DNA | 16 |
| abstract_inverted_index.Our | 201 |
| abstract_inverted_index.The | 88, 164 |
| abstract_inverted_index.and | 4, 53, 80, 109, 130, 139, 168, 206, 214 |
| abstract_inverted_index.are | 10 |
| abstract_inverted_index.but | 194 |
| abstract_inverted_index.its | 61 |
| abstract_inverted_index.may | 215 |
| abstract_inverted_index.not | 196 |
| abstract_inverted_index.one | 28 |
| abstract_inverted_index.the | 15, 30, 48, 76, 113, 144, 147, 153 |
| abstract_inverted_index.two | 11 |
| abstract_inverted_index.vs. | 158, 162 |
| abstract_inverted_index.was | 72, 185, 195 |
| abstract_inverted_index.(HER | 102 |
| abstract_inverted_index.High | 181 |
| abstract_inverted_index.cell | 5 |
| abstract_inverted_index.most | 41 |
| abstract_inverted_index.play | 208 |
| abstract_inverted_index.that | 204 |
| abstract_inverted_index.this | 44 |
| abstract_inverted_index.well | 59 |
| abstract_inverted_index.were | 117, 141 |
| abstract_inverted_index.with | 63, 187 |
| abstract_inverted_index.(TNM) | 107 |
| abstract_inverted_index.(χ2) | 122 |
| abstract_inverted_index.among | 90 |
| abstract_inverted_index.cells | 150 |
| abstract_inverted_index.cycle | 7 |
| abstract_inverted_index.exact | 125 |
| abstract_inverted_index.human | 96 |
| abstract_inverted_index.major | 31 |
| abstract_inverted_index.roles | 22, 210 |
| abstract_inverted_index.size, | 105 |
| abstract_inverted_index.test, | 123, 126 |
| abstract_inverted_index.tumor | 104 |
| abstract_inverted_index.using | 70, 119 |
| abstract_inverted_index.(CHK2) | 3 |
| abstract_inverted_index.(e.g., | 95 |
| abstract_inverted_index.20.38% | 157 |
| abstract_inverted_index.82.26% | 161 |
| abstract_inverted_index.Tissue | 67 |
| abstract_inverted_index.breast | 56, 64, 85, 114, 148, 171, 212 |
| abstract_inverted_index.cancer | 65, 86, 115, 149, 172, 213 |
| abstract_inverted_index.damage | 17 |
| abstract_inverted_index.factor | 99 |
| abstract_inverted_index.female | 84 |
| abstract_inverted_index.genome | 25 |
| abstract_inverted_index.growth | 98 |
| abstract_inverted_index.higher | 135 |
| abstract_inverted_index.kinase | 1 |
| abstract_inverted_index.linear | 176 |
| abstract_inverted_index.occurs | 39 |
| abstract_inverted_index.showed | 173 |
| abstract_inverted_index.study, | 45 |
| abstract_inverted_index.tissue | 155 |
| abstract_inverted_index.0.001), | 193 |
| abstract_inverted_index.0.026). | 180 |
| abstract_inverted_index.cancer, | 57 |
| abstract_inverted_index.factor. | 200 |
| abstract_inverted_index.factors | 94 |
| abstract_inverted_index.genomic | 37 |
| abstract_inverted_index.nucleus | 145 |
| abstract_inverted_index.overall | 110 |
| abstract_inverted_index.patient | 189 |
| abstract_inverted_index.playing | 20 |
| abstract_inverted_index.protein | 91 |
| abstract_inverted_index.results | 202 |
| abstract_inverted_index.suggest | 203 |
| abstract_inverted_index.tissues | 116 |
| abstract_inverted_index.(CDC25C) | 9 |
| abstract_inverted_index.24.24%). | 163 |
| abstract_inverted_index.abnormal | 34 |
| abstract_inverted_index.analysis | 69 |
| abstract_inverted_index.analyzed | 118 |
| abstract_inverted_index.cancers. | 42 |
| abstract_inverted_index.cellular | 35 |
| abstract_inverted_index.compared | 151 |
| abstract_inverted_index.division | 6 |
| abstract_inverted_index.identify | 75 |
| abstract_inverted_index.involved | 13 |
| abstract_inverted_index.logistic | 128 |
| abstract_inverted_index.observed | 142 |
| abstract_inverted_index.pathway, | 19 |
| abstract_inverted_index.positive | 175 |
| abstract_inverted_index.proteins | 12 |
| abstract_inverted_index.receptor | 100 |
| abstract_inverted_index.response | 18 |
| abstract_inverted_index.survival | 111, 132, 190 |
| abstract_inverted_index.targets. | 219 |
| abstract_inverted_index.analysis. | 133 |
| abstract_inverted_index.decreased | 188 |
| abstract_inverted_index.division, | 36 |
| abstract_inverted_index.epidermal | 97 |
| abstract_inverted_index.essential | 21 |
| abstract_inverted_index.hallmarks | 32 |
| abstract_inverted_index.important | 209 |
| abstract_inverted_index.patients. | 87 |
| abstract_inverted_index.potential | 217 |
| abstract_inverted_index.survival. | 66 |
| abstract_inverted_index.treatment | 218 |
| abstract_inverted_index.χ-square | 121 |
| abstract_inverted_index.Checkpoint | 0 |
| abstract_inverted_index.Fisher’s | 124 |
| abstract_inverted_index.associated | 186 |
| abstract_inverted_index.expression | 50, 77, 165, 182 |
| abstract_inverted_index.functional | 49 |
| abstract_inverted_index.identified | 47 |
| abstract_inverted_index.integrity. | 26 |
| abstract_inverted_index.microarray | 68 |
| abstract_inverted_index.prognostic | 199 |
| abstract_inverted_index.regression | 129 |
| abstract_inverted_index.Pearson’s | 120 |
| abstract_inverted_index.association | 62 |
| abstract_inverted_index.constructed | 73 |
| abstract_inverted_index.correlation | 177 |
| abstract_inverted_index.expression, | 92 |
| abstract_inverted_index.expressions | 136 |
| abstract_inverted_index.independent | 198 |
| abstract_inverted_index.instability | 38 |
| abstract_inverted_index.maintaining | 24 |
| abstract_inverted_index.pCHK2-Thr68 | 52, 79, 138, 167, 184, 205 |
| abstract_inverted_index.multivariate | 127 |
| abstract_inverted_index.relationship | 89 |
| abstract_inverted_index.(pCHK2-Thr68, | 156 |
| abstract_inverted_index.Significantly | 134 |
| abstract_inverted_index.paracancerous | 154 |
| abstract_inverted_index.Kaplan–Meier | 131 |
| abstract_inverted_index.pCDC25C-Ser216 | 54, 81, 140, 169, 207 |
| abstract_inverted_index.pCDC25C-Ser216, | 160 |
| abstract_inverted_index.classification), | 108 |
| abstract_inverted_index.clinicopathological | 93 |
| abstract_inverted_index.immunohistochemistry | 71 |
| abstract_inverted_index.tumor-node-metastasis | 106 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5100723747, https://openalex.org/A5100455409 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I177933477, https://openalex.org/I4210115928, https://openalex.org/I52357470 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.71599839 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |