The Expression of Activation Markers CD25 and CD69 Increases during Biologic Treatment of Psoriasis Article Swipe
Michał Adamczyk
,
Joanna Bartosińska
,
Dorota Raczkiewicz
,
Małgorzata Kowal
,
Agata Surdacka
,
Danuta Krasowska
,
Anna Michalak-Stoma
,
Dorota Krasowska
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/jcm12206573
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/jcm12206573
CD (cluster of differentiation) 69 and CD25 are considered early and late markers of the activation of lymphocytes, respectively. CD25 is a part of the IL-2 receptor and is present on the surface of immune and non-immune cells, with high amounts on activated lymphocytes and regulatory T cells. CD69 is expressed on various types of white blood cells, including newly activated lymphocytes, lymphocytes infiltrating tissues isolated from subjects with chronic auto-inflammatory diseases, several subtypes of memory T cells and regulatory T cells. Primarily, CD69 was considered to be an early marker of the activation of lymphocytes, but, right now, data derived from in vitro and in vivo studies have revealed the immunomodulatory role of this surface antigen. In 84 patients with psoriasis, of whom 28 were treated with different biologic drugs, as well as in 29 healthy control subjects, the expression of CD25 and CD69 on different subtypes of peripheral blood mononuclear cells (PBMCs) was studied with the use of flow cytometry. Significantly higher levels of CD3/CD69-, CD8/CD69- and CD19/CD69-positive PBMCs as well as within CD3+ cells were present in subjects suffering from psoriasis when compared to healthy controls. In patients with psoriasis who were treated with biologic drugs, the levels of CD3/CD69-, CD4/CD69- and CD19/CD69-positive PBMCs, and CD3/CD69 within CD3+ cells, CD4/CD69 within CD4+ cells, CD4/CD25 within CD4+ cells and CD19/CD69 within CD19+ cells were significantly higher than before therapy. Our results support a role for activation markers, especially CD69, in psoriasis. Further research is warranted to fully clarify their significance in this common dermatosis, especially during biologic treatment.
Related Topics
Concepts
CD69
IL-2 receptor
CD19
Medicine
Peripheral blood mononuclear cell
Immune system
CD3
Immunology
CD8
Flow cytometry
T cell
In vitro
Biology
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm12206573
- https://www.mdpi.com/2077-0383/12/20/6573/pdf?version=1697530338
- OA Status
- gold
- Cited By
- 21
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387702464
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387702464Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm12206573Digital Object Identifier
- Title
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The Expression of Activation Markers CD25 and CD69 Increases during Biologic Treatment of PsoriasisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-10-17Full publication date if available
- Authors
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Michał Adamczyk, Joanna Bartosińska, Dorota Raczkiewicz, Małgorzata Kowal, Agata Surdacka, Danuta Krasowska, Anna Michalak-Stoma, Dorota KrasowskaList of authors in order
- Landing page
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https://doi.org/10.3390/jcm12206573Publisher landing page
- PDF URL
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https://www.mdpi.com/2077-0383/12/20/6573/pdf?version=1697530338Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2077-0383/12/20/6573/pdf?version=1697530338Direct OA link when available
- Concepts
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CD69, IL-2 receptor, CD19, Medicine, Peripheral blood mononuclear cell, Immune system, CD3, Immunology, CD8, Flow cytometry, T cell, In vitro, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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21Total citation count in OpenAlex
- Citations by year (recent)
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2025: 17, 2024: 4Per-year citation counts (last 5 years)
- References (count)
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35Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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