The extent of endoscopic sinus surgery in patients with severe chronic rhinosinusitis with nasal polyps (AirGOs Operative) Article Swipe
Markus Lilja
,
Paula Virkkula
,
Sari Hammarén‐Malmi
,
Anu Laulajainen‐Hongisto
,
Lena Hafrén
,
Paula Kauppi
,
Johanna Sahlman
,
Wytske J. Fokkens
,
Sietze Reitsma
,
Sanna Toppila‐Salmi
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.4193/rhinol/21.029
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.4193/rhinol/21.029
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the nose and paranasal sinuses characterized by intense inflammation, decreased health-related quality of life (HRQoL), and in severe cases high frequency of co-morbidities and recurrence despite treatment. Conservative treatment consists of nasal lavage, intranasal corticosteroids, and courses of oral corticosteroids, and antibiotics in exacerbations. Endoscopic sinus surgery (ESS) and/or biological therapy is considered if appropriate conservative treatment is not sufficient. The optimal extent of ESS in recalcitrant CRSwNP is not known. The aim of this randomized controlled trial is to evaluate and compare the efficacy and safety of limited ESS with partial ethmoidectomy with extended ESS with total ethmoidectomy in patients with severe CRSwNP. Methods: AirGOs Operative is a randomized controlled trial. It is an investigator-driven multicenter trial led by Helsinki University Hospital. The two surgery arms are compared. The primary outcome is the change in the SNOT-22 score at the 12-month follow-up. Secondary outcomes include the change in the SNOT-22 score at 24-months follow-up, the changes in polyp score, Lund-Mackay (LM) CT score, health-related quality of life (HRQoL), loss of productivity, nasal patency (peak nasal inspiratory flow (PNIF) ± acoustic rhinometry (ARM), olfaction test (Sniffin’ Sticks, identification), lung function (spirometry and PEF) and findings in pathological analysis at 12/24-months follow-up. Discussion: AirGOs Operative trial will lead to a better understanding of the optimal extent of ethmoidectomy in the treatment of recalcitrant severe CRSwNP.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4193/rhinol/21.029
- https://doi.org/10.4193/rhinol/21.029
- OA Status
- gold
- Cited By
- 6
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3194272108
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3194272108Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4193/rhinol/21.029Digital Object Identifier
- Title
-
The extent of endoscopic sinus surgery in patients with severe chronic rhinosinusitis with nasal polyps (AirGOs Operative)Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-23Full publication date if available
- Authors
-
Markus Lilja, Paula Virkkula, Sari Hammarén‐Malmi, Anu Laulajainen‐Hongisto, Lena Hafrén, Paula Kauppi, Johanna Sahlman, Wytske J. Fokkens, Sietze Reitsma, Sanna Toppila‐SalmiList of authors in order
- Landing page
-
https://doi.org/10.4193/rhinol/21.029Publisher landing page
- PDF URL
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https://doi.org/10.4193/rhinol/21.029Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.4193/rhinol/21.029Direct OA link when available
- Concepts
-
Medicine, Ethmoidectomy, Nasal polyps, Surgery, Quality of life (healthcare), Sinusitis, Nose, Randomized controlled trial, Functional endoscopic sinus surgery, Paranasal sinuses, Acoustic rhinometry, Internal medicine, Maxillary sinus, NursingTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2023: 1, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
20Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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