The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut Article Swipe
Rana Ramadan
,
Valérie M. Wouters
,
Sanne M. van Neerven
,
Nina E. de Groot
,
Tânia Martins Garcia
,
Vanessa Muncan
,
Olivia D. Franklin
,
Michelle Battle
,
Karen-Sue Carlson
,
Joshua D.G. Leach
,
Owen J. Sansom
,
Olivier Boulard
,
Mathias Chamaillard
,
Louis Vermeulen
,
Jan Paul Medema
,
David J. Huels
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1242/bio.059544
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1242/bio.059544
The rapid renewal of the epithelial gut lining is fuelled by stem cells that reside at the base of intestinal crypts. The signal transduction pathways and morphogens that regulate intestinal stem cell self-renewal and differentiation have been extensively characterised. In contrast, although extracellular matrix (ECM) components form an integral part of the intestinal stem cell niche, their direct influence on the cellular composition is less well understood. We set out to systematically compare the effect of two ECM classes, the interstitial matrix and the basement membrane, on the intestinal epithelium. We found that both collagen I and laminin-containing cultures allow growth of small intestinal epithelial cells with all cell types present in both cultures, albeit at different ratios. The collagen cultures contained a subset of cells enriched in fetal-like markers. In contrast, laminin increased Lgr5+ stem cells and Paneth cells, and induced crypt-like morphology changes. The transition from a collagen culture to a laminin culture resembled gut development in vivo. The dramatic ECM remodelling was accompanied by a local expression of the laminin receptor ITGA6 in the crypt-forming epithelium. Importantly, deletion of laminin in the adult mouse resulted in a marked reduction of adult intestinal stem cells. Overall, our data support the hypothesis that the formation of intestinal crypts is induced by an increased laminin concentration in the ECM.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1242/bio.059544
- https://journals.biologists.com/bio/article-pdf/11/12/bio059544/2329842/bio059544.pdf
- OA Status
- gold
- Cited By
- 19
- References
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- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4308639845
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4308639845Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1242/bio.059544Digital Object Identifier
- Title
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The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gutWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-11-09Full publication date if available
- Authors
-
Rana Ramadan, Valérie M. Wouters, Sanne M. van Neerven, Nina E. de Groot, Tânia Martins Garcia, Vanessa Muncan, Olivia D. Franklin, Michelle Battle, Karen-Sue Carlson, Joshua D.G. Leach, Owen J. Sansom, Olivier Boulard, Mathias Chamaillard, Louis Vermeulen, Jan Paul Medema, David J. HuelsList of authors in order
- Landing page
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https://doi.org/10.1242/bio.059544Publisher landing page
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https://journals.biologists.com/bio/article-pdf/11/12/bio059544/2329842/bio059544.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://journals.biologists.com/bio/article-pdf/11/12/bio059544/2329842/bio059544.pdfDirect OA link when available
- Concepts
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Laminin, Biology, Extracellular matrix, Stem cell, Cell biology, Crypt, Basement membrane, Cellular differentiation, LGR5, Immunology, Cancer stem cell, Endocrinology, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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19Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 4, 2023: 3, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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60Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Paneth | 139 |
| abstract_inverted_index.albeit | 115 |
| abstract_inverted_index.cells, | 140 |
| abstract_inverted_index.cells. | 197 |
| abstract_inverted_index.crypts | 209 |
| abstract_inverted_index.direct | 58 |
| abstract_inverted_index.effect | 75 |
| abstract_inverted_index.growth | 101 |
| abstract_inverted_index.lining | 8 |
| abstract_inverted_index.marked | 191 |
| abstract_inverted_index.matrix | 44, 82 |
| abstract_inverted_index.niche, | 56 |
| abstract_inverted_index.reside | 15 |
| abstract_inverted_index.signal | 23 |
| abstract_inverted_index.subset | 124 |
| abstract_inverted_index.compare | 73 |
| abstract_inverted_index.crypts. | 21 |
| abstract_inverted_index.culture | 151, 155 |
| abstract_inverted_index.fuelled | 10 |
| abstract_inverted_index.induced | 142, 211 |
| abstract_inverted_index.laminin | 133, 154, 173, 183, 215 |
| abstract_inverted_index.present | 111 |
| abstract_inverted_index.ratios. | 118 |
| abstract_inverted_index.renewal | 3 |
| abstract_inverted_index.support | 201 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.Overall, | 198 |
| abstract_inverted_index.although | 42 |
| abstract_inverted_index.basement | 85 |
| abstract_inverted_index.cellular | 62 |
| abstract_inverted_index.changes. | 145 |
| abstract_inverted_index.classes, | 79 |
| abstract_inverted_index.collagen | 95, 120, 150 |
| abstract_inverted_index.cultures | 99, 121 |
| abstract_inverted_index.deletion | 181 |
| abstract_inverted_index.dramatic | 162 |
| abstract_inverted_index.enriched | 127 |
| abstract_inverted_index.integral | 49 |
| abstract_inverted_index.markers. | 130 |
| abstract_inverted_index.pathways | 25 |
| abstract_inverted_index.receptor | 174 |
| abstract_inverted_index.regulate | 29 |
| abstract_inverted_index.resulted | 188 |
| abstract_inverted_index.contained | 122 |
| abstract_inverted_index.contrast, | 41, 132 |
| abstract_inverted_index.cultures, | 114 |
| abstract_inverted_index.different | 117 |
| abstract_inverted_index.formation | 206 |
| abstract_inverted_index.increased | 134, 214 |
| abstract_inverted_index.influence | 59 |
| abstract_inverted_index.membrane, | 86 |
| abstract_inverted_index.reduction | 192 |
| abstract_inverted_index.resembled | 156 |
| abstract_inverted_index.components | 46 |
| abstract_inverted_index.crypt-like | 143 |
| abstract_inverted_index.epithelial | 6, 105 |
| abstract_inverted_index.expression | 170 |
| abstract_inverted_index.fetal-like | 129 |
| abstract_inverted_index.hypothesis | 203 |
| abstract_inverted_index.intestinal | 20, 30, 53, 89, 104, 195, 208 |
| abstract_inverted_index.morphogens | 27 |
| abstract_inverted_index.morphology | 144 |
| abstract_inverted_index.transition | 147 |
| abstract_inverted_index.accompanied | 166 |
| abstract_inverted_index.composition | 63 |
| abstract_inverted_index.development | 158 |
| abstract_inverted_index.epithelium. | 90, 179 |
| abstract_inverted_index.extensively | 38 |
| abstract_inverted_index.remodelling | 164 |
| abstract_inverted_index.understood. | 67 |
| abstract_inverted_index.Importantly, | 180 |
| abstract_inverted_index.interstitial | 81 |
| abstract_inverted_index.self-renewal | 33 |
| abstract_inverted_index.transduction | 24 |
| abstract_inverted_index.concentration | 216 |
| abstract_inverted_index.crypt-forming | 178 |
| abstract_inverted_index.extracellular | 43 |
| abstract_inverted_index.characterised. | 39 |
| abstract_inverted_index.systematically | 72 |
| abstract_inverted_index.differentiation | 35 |
| abstract_inverted_index.laminin-containing | 98 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 16 |
| citation_normalized_percentile.value | 0.88769233 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |