The First Case of the Identification of a Microorganism Directly from Whole Blood Using MALDI-TOF Mass Spectrometry in an Onco-Hematological Pediatric Patient with Bloodstream Infection Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.3390/antibiotics14020149
Background: Bloodstream infections affect up to 20% of pediatric cancer patients receiving intensive care, contributing significantly to morbidity and mortality, with infection-related mortality rates reported to be as high as 16%. Methods: The identification of microorganisms directly from whole blood is difficult due to several factors, such as interference from host genomic material, low bacterial load, the endogenous components of whole blood and exogenous substances, which can interfere with the identification process. Nevertheless, rapid microbial diagnosis remains of paramount importance in these patients. Results and Conclusion: Here, we present the first case of bacterial pathogen identification directly from whole blood using MALDI-TOF mass spectrometry in an onco-hematological pediatric patient affected by sepsis and admitted to Bambino Gesù Children’s Hospital (IRCCS) in Rome, Italy.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antibiotics14020149
- OA Status
- gold
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407141935
Raw OpenAlex JSON
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https://openalex.org/W4407141935Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/antibiotics14020149Digital Object Identifier
- Title
-
The First Case of the Identification of a Microorganism Directly from Whole Blood Using MALDI-TOF Mass Spectrometry in an Onco-Hematological Pediatric Patient with Bloodstream InfectionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-04Full publication date if available
- Authors
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Venere Cortazzo, Maria del Carmen Pereyra Boza, Vanessa Tuccio Guarna Assanti, Gianluca Foglietta, Gianluca Vrenna, Marilena Agosta, Elena Chaiter, Martina Rossitto, Barbara Lucignano, Manuela Onori, Valeria Fox, Marco Becilli, Pietro Merli, Filippo Frioni, Carlo Federico Perno, Paola BernaschiList of authors in order
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https://doi.org/10.3390/antibiotics14020149Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.3390/antibiotics14020149Direct OA link when available
- Concepts
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Sepsis, Medicine, Bacteremia, Whole blood, Pathogen, Blood culture, Bloodstream infection, Intensive care medicine, Blood cancer, Pediatric cancer, Internal medicine, Cancer, Microbiology, Antibiotics, Immunology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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18Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W1904484517, https://openalex.org/W2989556232, https://openalex.org/W3200908896, https://openalex.org/W2803481513, https://openalex.org/W4315650805, https://openalex.org/W2310013765, https://openalex.org/W2607646059, https://openalex.org/W2118000393, https://openalex.org/W2096104385, https://openalex.org/W2040632649, https://openalex.org/W2062139734, https://openalex.org/W3181632055, https://openalex.org/W4391556453, https://openalex.org/W4391541380, https://openalex.org/W4289951527, https://openalex.org/W4295980677, https://openalex.org/W3198620311, https://openalex.org/W4225318474 |
| referenced_works_count | 18 |
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| corresponding_author_ids | https://openalex.org/A5070265360, https://openalex.org/A5065918086 |
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| corresponding_institution_ids | https://openalex.org/I4210123352, https://openalex.org/I4210153126 |
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