The Formulation of Curcumin: 2-Hydroxypropyl-β-cyclodextrin Complex with Smart Hydrogel for Prolonged Release of Curcumin Article Swipe
Ljubiša Nikolić
,
Maja Urošević
,
Vesna Nikolić
,
Ivana Gajić
,
Ana Dinić
,
Vojkan Miljković
,
Srđan Rakić
,
Sanja Đokić
,
Jelena Kesić
,
Snežana Ilić‐Stojanović
,
Goran Nikolić
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics15020382
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics15020382
Curcumin comes from the plant species Curcuma longa and shows numerous pharmacological activities. There are numerous curcumin formulations with gels or cyclodextrins in order to increase its solubility and bioavailability. This paper presents the formulation of complex of curcumin with 2-hydroxypropyl-β-cyclodextrin in a thermosensitive hydrogel, based on N-isopropylmethacrylamide and N-isopropylacrylamide with ethylene glycol dimethacrylate as a crosslinker. The product was characterized by chemical methods and also by FTIR, HPLC, DSC, SEM, XRD. The results show that synthesis was successfully done. With an increase in the quantity of crosslinker in the hydrogels, the starting release and the release rate of curcumin from the formulation of the complex with hydrogels decreases. The release rate of curcumin from the gel complex formulation is constant over time. It is possible to design a formulation that will release curcumin for more than 60 days. In order to determine the mechanism and kinetics of curcumin release, various mathematical models were applied by using the DDSolver package for Microsoft Excel application. The Korsmeyer-Peppas model best describes the release of curcumin from the gel formulation of the complex, while the values for the diffusion exponent (0.063–0.074) shows that mechanism of the release rate is based on diffusion.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/pharmaceutics15020382
- https://www.mdpi.com/1999-4923/15/2/382/pdf?version=1675996470
- OA Status
- gold
- Cited By
- 17
- References
- 64
- Related Works
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- OpenAlex ID
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- OpenAlex ID
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https://openalex.org/W4317733167Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/pharmaceutics15020382Digital Object Identifier
- Title
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The Formulation of Curcumin: 2-Hydroxypropyl-β-cyclodextrin Complex with Smart Hydrogel for Prolonged Release of CurcuminWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-22Full publication date if available
- Authors
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Ljubiša Nikolić, Maja Urošević, Vesna Nikolić, Ivana Gajić, Ana Dinić, Vojkan Miljković, Srđan Rakić, Sanja Đokić, Jelena Kesić, Snežana Ilić‐Stojanović, Goran NikolićList of authors in order
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https://doi.org/10.3390/pharmaceutics15020382Publisher landing page
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https://www.mdpi.com/1999-4923/15/2/382/pdf?version=1675996470Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1999-4923/15/2/382/pdf?version=1675996470Direct OA link when available
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Curcumin, Chemistry, Self-healing hydrogels, Bioavailability, Ethylene glycol, Controlled release, Solubility, Cyclodextrin, Fourier transform infrared spectroscopy, Chromatography, Chemical engineering, Materials science, Organic chemistry, Nanotechnology, Pharmacology, Biochemistry, Medicine, EngineeringTop concepts (fields/topics) attached by OpenAlex
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17Total citation count in OpenAlex
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2025: 7, 2024: 8, 2023: 2Per-year citation counts (last 5 years)
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64Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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