The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects Article Swipe
Farhad Dehkhoda
,
Christine M. M. Lee
,
Johan Medina
,
Andrew J. Brooks
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2018.00035
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2018.00035
The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiovascular, renal, gastrointestinal, and reproductive systems. In addition, growth hormone signaling is an important regulator of aging and plays a significant role in cancer development. Growth hormone activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor. JAK2 activation is required for growth hormone-mediated activation of STAT1, STAT3, and STAT5, and the negative regulation of JAK-STAT signaling comprises an important step in the control of this signaling pathway. The GHR also activates the Src family kinase signaling pathway independent of JAK2. This review covers the molecular mechanisms of GHR activation and signal transduction as well as the physiological consequences of growth hormone signaling.
Related Topics
Concepts
SOCS2
Growth hormone receptor
Signal transduction
Cell biology
Growth-hormone-releasing hormone receptor
Hormone receptor
JAK-STAT signaling pathway
Hormone
Biology
Receptor
Janus kinase 2
Proto-oncogene tyrosine-protein kinase Src
Insulin-like growth factor 1 receptor
Cancer research
Growth factor
Endocrinology
Receptor tyrosine kinase
Growth hormone
Biochemistry
Cancer
Genetics
Suppressor
Breast cancer
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2018.00035
- https://www.frontiersin.org/articles/10.3389/fendo.2018.00035/pdf
- OA Status
- gold
- Cited By
- 261
- References
- 336
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2790718366
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2790718366Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2018.00035Digital Object Identifier
- Title
-
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological AspectsWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-02-13Full publication date if available
- Authors
-
Farhad Dehkhoda, Christine M. M. Lee, Johan Medina, Andrew J. BrooksList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2018.00035Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2018.00035/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2018.00035/pdfDirect OA link when available
- Concepts
-
SOCS2, Growth hormone receptor, Signal transduction, Cell biology, Growth-hormone-releasing hormone receptor, Hormone receptor, JAK-STAT signaling pathway, Hormone, Biology, Receptor, Janus kinase 2, Proto-oncogene tyrosine-protein kinase Src, Insulin-like growth factor 1 receptor, Cancer research, Growth factor, Endocrinology, Receptor tyrosine kinase, Growth hormone, Biochemistry, Cancer, Genetics, Suppressor, Breast cancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
261Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 35, 2024: 35, 2023: 48, 2022: 45, 2021: 45Per-year citation counts (last 5 years)
- References (count)
-
336Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.(GHR), | 4 |
| abstract_inverted_index.(STAT) | 66 |
| abstract_inverted_index.Growth | 54 |
| abstract_inverted_index.STAT1, | 99 |
| abstract_inverted_index.STAT3, | 100 |
| abstract_inverted_index.STAT5, | 102 |
| abstract_inverted_index.cancer | 52 |
| abstract_inverted_index.covers | 136 |
| abstract_inverted_index.family | 127 |
| abstract_inverted_index.growth | 1, 37, 84, 95, 153 |
| abstract_inverted_index.kinase | 59, 128 |
| abstract_inverted_index.recent | 70 |
| abstract_inverted_index.renal, | 30 |
| abstract_inverted_index.review | 135 |
| abstract_inverted_index.signal | 144 |
| abstract_inverted_index.binding | 86 |
| abstract_inverted_index.control | 116 |
| abstract_inverted_index.growth, | 11 |
| abstract_inverted_index.hormone | 2, 38, 55, 85, 154 |
| abstract_inverted_index.pathway | 130 |
| abstract_inverted_index.related | 25 |
| abstract_inverted_index.studies | 71 |
| abstract_inverted_index.JAK-STAT | 108 |
| abstract_inverted_index.although | 5 |
| abstract_inverted_index.negative | 105 |
| abstract_inverted_index.pathway, | 68 |
| abstract_inverted_index.pathway. | 120 |
| abstract_inverted_index.provided | 73 |
| abstract_inverted_index.receptor | 3 |
| abstract_inverted_index.required | 93 |
| abstract_inverted_index.systems. | 34 |
| abstract_inverted_index.activates | 56, 124 |
| abstract_inverted_index.activator | 63 |
| abstract_inverted_index.addition, | 36 |
| abstract_inverted_index.comprises | 110 |
| abstract_inverted_index.functions | 17 |
| abstract_inverted_index.important | 15, 42, 112 |
| abstract_inverted_index.including | 18 |
| abstract_inverted_index.mechanism | 79 |
| abstract_inverted_index.molecular | 138 |
| abstract_inverted_index.processes | 24 |
| abstract_inverted_index.receptor. | 89 |
| abstract_inverted_index.regulator | 43 |
| abstract_inverted_index.signaling | 39, 67, 109, 119, 129 |
| abstract_inverted_index.activation | 82, 91, 97, 142 |
| abstract_inverted_index.biological | 16 |
| abstract_inverted_index.mechanisms | 139 |
| abstract_inverted_index.metabolism | 20 |
| abstract_inverted_index.regulating | 10, 19 |
| abstract_inverted_index.regulation | 106 |
| abstract_inverted_index.signaling. | 155 |
| abstract_inverted_index.transducer | 61 |
| abstract_inverted_index.controlling | 22 |
| abstract_inverted_index.independent | 131 |
| abstract_inverted_index.significant | 49 |
| abstract_inverted_index.(JAK)-signal | 60 |
| abstract_inverted_index.consequences | 151 |
| abstract_inverted_index.development. | 53 |
| abstract_inverted_index.reproductive | 33 |
| abstract_inverted_index.transduction | 145 |
| abstract_inverted_index.physiological | 23, 150 |
| abstract_inverted_index.transcription | 65 |
| abstract_inverted_index.understanding | 76 |
| abstract_inverted_index.hepatobiliary, | 28 |
| abstract_inverted_index.cardiovascular, | 29 |
| abstract_inverted_index.hormone-mediated | 96 |
| abstract_inverted_index.gastrointestinal, | 31 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 96 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6800000071525574 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.99486324 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |