The Health for Life in Singapore (HELIOS) Study: delivering Precision Medicine research for Asian populations Article Swipe
Xiaoyan Wang
,
Theresia Mina
,
Nilanjana Sadhu
,
Pritesh Jain
,
Hong Kiat Ng
,
Dorrain Yanwen Low
,
Darwin Tay
,
Terry Y.Y. Tong
,
Wee-Lin Choo
,
Swat Kim Kerk
,
Guo Liang Low
,
Benjamin Chih Chiang Lam
,
Rinkoo Dalan
,
Gervais Wanseicheong
,
Yik Weng Yew
,
Ee-J Leow
,
Soren Brage
,
Gregory Michelotti
,
Kari E. Wong
,
Patricia A. Sheridan
,
Pin Yan Low
,
Zhen Xuan Yeo
,
Nicolas Bertin
,
Claire Bellis
,
Maxime Hebrard
,
Pierre-Alexis Goy
,
Konstantinos K. Tsilidis
,
Harinakshi Sanikini
,
Xue Li Guan
,
Tock Han Lim
,
Lionel Lee
,
James D. Best
,
Patrick Tan
,
Paul Elliott
,
Eng Sing Lee
,
Jimmy Lee
,
Joanne Ngeow
,
Elio Ríboli
,
Max Lam
,
Marie Loh
,
John C. Chambers
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.05.14.24307259
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.05.14.24307259
Asian people are under-represented in population-based, clinical, and genomic research. 1,2 To address this gap, we have initiated the HELIOS longitudinal cohort study, comprising comprehensive behavioural, phenotypic, and genomic measurements from 10,004 Asian men and women of Chinese, Indian or Malay background. Phenotyping has been carried out using validated approaches, that are internationally interoperable. Health record linkage enriches both baseline phenotyping and evaluation of prospective outcomes. The integrated multi-omics data include whole-genome and RNA sequencing, quantification of DNA methylation, and metabolomic profiling. Our data reveal extensive lifestyle, physiological, genomic, and molecular diversity between the distinct Asian ethnic groups, and the biological interconnectivity between functional layers. This includes characterisation of divergent patterns of genome regulation between Asian individuals, that correlate with differences in educational attainment, dietary quality, and adiposity, and which overlap transcription factors and DNA methylation sites linked to the development of diabetes and other chronic diseases. Our unique HELIOS Asian Precision Medicine cohort study represents a state-of-the art platform to enable biomedical researchers to understand the aetiology and pathogenesis of diverse disease outcomes in Asia, and to generate insights that have the potential to improve health outcomes for Asian populations globally.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.05.14.24307259
- https://www.medrxiv.org/content/medrxiv/early/2024/05/15/2024.05.14.24307259.full.pdf
- OA Status
- green
- Cited By
- 12
- References
- 51
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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- DOI
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https://doi.org/10.1101/2024.05.14.24307259Digital Object Identifier
- Title
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The Health for Life in Singapore (HELIOS) Study: delivering Precision Medicine research for Asian populationsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-15Full publication date if available
- Authors
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Xiaoyan Wang, Theresia Mina, Nilanjana Sadhu, Pritesh Jain, Hong Kiat Ng, Dorrain Yanwen Low, Darwin Tay, Terry Y.Y. Tong, Wee-Lin Choo, Swat Kim Kerk, Guo Liang Low, Benjamin Chih Chiang Lam, Rinkoo Dalan, Gervais Wanseicheong, Yik Weng Yew, Ee-J Leow, Soren Brage, Gregory Michelotti, Kari E. Wong, Patricia A. Sheridan, Pin Yan Low, Zhen Xuan Yeo, Nicolas Bertin, Claire Bellis, Maxime Hebrard, Pierre-Alexis Goy, Konstantinos K. Tsilidis, Harinakshi Sanikini, Xue Li Guan, Tock Han Lim, Lionel Lee, James D. Best, Patrick Tan, Paul Elliott, Eng Sing Lee, Jimmy Lee, Joanne Ngeow, Elio Ríboli, Max Lam, Marie Loh, John C. ChambersList of authors in order
- Landing page
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https://doi.org/10.1101/2024.05.14.24307259Publisher landing page
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https://www.medrxiv.org/content/medrxiv/early/2024/05/15/2024.05.14.24307259.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2024/05/15/2024.05.14.24307259.full.pdfDirect OA link when available
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12Total citation count in OpenAlex
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2025: 10, 2024: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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