The hierarchical taxonomy of psychopathology in clinical high risk for psychosis: Validation and extension. Article Swipe
Trevor F. Williams
,
Alexander L. Williams
,
Henry R. Cowan
,
Elaine F. Walker
,
Tyrone D. Cannon
,
Carrie E. Bearden
,
Matcheri S. Keshavan
,
Barbara A. Cornblatt
,
Jean Addington
,
Scott W. Woods
,
Diana O. Perkins
,
Daniel H. Mathalon
,
Kristin S. Cadenhead
,
William S. Stone
,
Vijay A. Mittal
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1037/abn0000893
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1037/abn0000893
The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium's transdiagnostic dimensional model of psychopathology has considerable support; however, this model has been underresearched in individuals at clinical high risk for psychosis (CHR-P), a population that may advance the model. CHR-P individuals not only have attenuated psychotic symptoms that vary in severity, but also have many comorbid diagnoses and varied clinical outcomes, including disorders with uncertain relations to HiTOP (e.g., obsessive-compulsive disorder). The present study used self-report and interview data from North American Prodrome Longitudinal Study-3 (710 CHR, 96 controls) to replicate the HiTOP model and test specific hypotheses regarding disorders with uncertain relations to its dimensions. Additionally, the present study examined the HiTOP model in relation to childhood trauma, declines in social functioning, and development of full psychosis. Confirmatory factor analysis indicated that the HiTOP model's fit was nearly adequate (e.g., comparative fit index = .89), though several theory-relevant modifications were indicated. Additionally, specific tests were conducted to gain a more fine-grained perspective on how disorders with less clear prior evidence were related to the HiTOP model. Notable findings from these analyses include bipolar spectrum disorders relating to the psychosis super spectrum (i.e., .39 loading), and obsessive-compulsive disorder showing a complex pattern of loadings (e.g., internalizing and psychosis). The final model parsimoniously accounted for childhood trauma (e.g., super spectra rs = .22-.32), associations with current functioning, and predicted future conversion to a psychotic disorder (e.g., super spectra R² = .13). Overall, these results inform the HiTOP model and suggest its promise for CHR-P research. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1037/abn0000893
- OA Status
- hybrid
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393259474
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https://openalex.org/W4393259474Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1037/abn0000893Digital Object Identifier
- Title
-
The hierarchical taxonomy of psychopathology in clinical high risk for psychosis: Validation and extension.Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-03-28Full publication date if available
- Authors
-
Trevor F. Williams, Alexander L. Williams, Henry R. Cowan, Elaine F. Walker, Tyrone D. Cannon, Carrie E. Bearden, Matcheri S. Keshavan, Barbara A. Cornblatt, Jean Addington, Scott W. Woods, Diana O. Perkins, Daniel H. Mathalon, Kristin S. Cadenhead, William S. Stone, Vijay A. MittalList of authors in order
- Landing page
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https://doi.org/10.1037/abn0000893Publisher landing page
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1037/abn0000893Direct OA link when available
- Concepts
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Psychopathology, Prodrome, Psychosis, Psychology, Clinical psychology, Bipolar disorder, Population, Developmental psychopathology, Psychiatry, Schizophrenia (object-oriented programming), Confirmatory factor analysis, Structural equation modeling, Medicine, Mood, Statistics, Mathematics, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2340656051, https://openalex.org/W2619419842, https://openalex.org/W2073869708, https://openalex.org/W3025481747, https://openalex.org/W2154978471, https://openalex.org/W2896024746, https://openalex.org/W3215083003, https://openalex.org/W3127024923, https://openalex.org/W2599735142, https://openalex.org/W3171400303, https://openalex.org/W2120654343, https://openalex.org/W3097386371, https://openalex.org/W3182961820, https://openalex.org/W4380080334, https://openalex.org/W2788262425, https://openalex.org/W3017128210, https://openalex.org/W2538905988, https://openalex.org/W3119417831, https://openalex.org/W2262746473, https://openalex.org/W4213434112, https://openalex.org/W3015945398, https://openalex.org/W2068992432, https://openalex.org/W2096316044, https://openalex.org/W2914802283, https://openalex.org/W2146069882, https://openalex.org/W2608746035, https://openalex.org/W2911029283, https://openalex.org/W2110726313, https://openalex.org/W3137054124, https://openalex.org/W4361290406, https://openalex.org/W2511764987 |
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