The ahpC c−54t compensatory mutation is not always a valid surrogate for isoniazid resistance in Mycobacterium tuberculosis Article Swipe
Viktória Szél
,
Jody Phelan
,
Sophia B. Georghiou
,
David L. Dolinger
,
Taane G. Clark
,
Stefan Niemann
,
Lilla Lörinczi
,
Claudio U. Köser
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1128/aac.00265-25
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1128/aac.00265-25
Thirteen commercial genotypic antimicrobial susceptibility assays interrogate mutations upstream of ahpC to infer isoniazid resistance for Mycobacterium tuberculosis . We demonstrate that relying on one of these compensatory mutations (i.e., ahpC c−54t)—rather than causative resistance mutations in katG that ahpC compensates for—can result in systematic false-resistant results for isoniazid with the Cepheid Xpert MTB/XDR and suboptimal treatment. The WHO mutation catalog should be refined to address this scenario.
Related Topics
Concepts
Isoniazid
Mycobacterium tuberculosis
Mutation
Tuberculosis
Genotype
Biology
Microbiology
Drug resistance
Virology
Antibiotic resistance
Resistance mutation
Acquired resistance
Genetics
Antibiotics
Medicine
Polymerase chain reaction
Gene
Reverse transcriptase
Pathology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/aac.00265-25
- OA Status
- hybrid
- Cited By
- 1
- References
- 16
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409669323
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409669323Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/aac.00265-25Digital Object Identifier
- Title
-
The ahpC c−54t compensatory mutation is not always a valid surrogate for isoniazid resistance in Mycobacterium tuberculosisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-22Full publication date if available
- Authors
-
Viktória Szél, Jody Phelan, Sophia B. Georghiou, David L. Dolinger, Taane G. Clark, Stefan Niemann, Lilla Lörinczi, Claudio U. KöserList of authors in order
- Landing page
-
https://doi.org/10.1128/aac.00265-25Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1128/aac.00265-25Direct OA link when available
- Concepts
-
Isoniazid, Mycobacterium tuberculosis, Mutation, Tuberculosis, Genotype, Biology, Microbiology, Drug resistance, Virology, Antibiotic resistance, Resistance mutation, Acquired resistance, Genetics, Antibiotics, Medicine, Polymerase chain reaction, Gene, Reverse transcriptase, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
16Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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