The immune checkpoint molecule B7-H4 regulates β-cell mass and insulin secretion by modulating cholesterol metabolism through Stat5 signalling Article Swipe
Related Concepts
Secretion
STAT5
Cell biology
Signalling
Immune system
Metabolism
Insulin
Immune checkpoint
Chemistry
Signal transduction
Biology
Endocrinology
Biochemistry
Immunology
Immunotherapy
Fangzhen Xia
,
Ziteng Zhang
,
Zhen Qian
,
Xiaoyu Fang
,
Junxue Wang
,
Yan Wang
,
Guoting Sun
,
Yuefeng Yu
,
N. Wang
,
Zhen Jian-cun
,
Yan Liu
,
Yingli Lu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.molmet.2024.102069
· OA: W4404515945
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.molmet.2024.102069
· OA: W4404515945
Our study demonstrated that B7-H4 plays an important role in regulating β-cell mass and insulin secretion, which may shed new light on the development of novel strategies for T2D treatment.
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