The Impact of Anti-rheumatic Drugs on the Seroprevalence of Anti-SARS-CoV-2 Antibodies in a Cohort of Patients With Inflammatory Arthritis: The MAINSTREAM Study Article Swipe
Ennio Giulio Favalli
,
Andrea Gobbini
,
Mauro Bombaci
,
Gabriella Maioli
,
Martina Biggioggero
,
Elisa Pesce
,
Andrea Favalli
,
Martina Martinović
,
Tanya Fabbris
,
Edoardo Marchisio
,
Alessandra Bandera
,
Andrea Gori
,
Sergio Abrignani
,
Renata Grifantini
,
Roberto Caporali
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2022.850858
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2022.850858
Objectives Given the high occurrence of asymptomatic subsets, the true prevalence of SARS-CoV-2 infection in rheumatic patients is still underestimated. This study aims to evaluate the seroprevalence of SARS-CoV-2 antibodies in rheumatic musculoskeletal diseases (RMD) patients receiving immunomodulatory drugs. Methods All consecutive patients with rheumatoid arthritis or spondyloarthritis receiving disease-modifying antirheumatic drugs (DMARDs) evaluated between 4th May and 16th June 2020 were included. All participants were tested for anti-SARS-CoV-2 antibodies (IgG, IgM, IgA) by ELISA and were questioned about previous COVID-19 symptoms and clinical course. Results were compared with healthy population from the same region and with a control group of healthy subjects diagnosed with confirmed COVID-19. Results The study population includes 358 patients. The overall prevalence of anti-SARS-CoV-2 antibodies (18.4%) was higher than prevalence rate based on swab-positivity (1.12%) or clinically suspected cases (10.6%), but consistent with seroprevalence observed in the healthy population. Among seropositive patients 58% were asymptomatic. Mean anti-SARS-CoV-2 titer was comparable with the control group. No differences in seroprevalence were observed according to age, sex, rheumatic disease and treatment with conventional, biologic or targeted synthetic DMARDs, whereas glucocorticoids and comorbidities resulted in higher seroprevalence rate. Conclusions The results of this study are reassuring about the low impact of RMDs and immunomodulatory therapies on the risk and clinical course of COVID-19 and on humoral immune response to SARS-CoV-2 infection.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmed.2022.850858
- https://www.frontiersin.org/articles/10.3389/fmed.2022.850858/pdf
- OA Status
- gold
- Cited By
- 4
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4220984505
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4220984505Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmed.2022.850858Digital Object Identifier
- Title
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The Impact of Anti-rheumatic Drugs on the Seroprevalence of Anti-SARS-CoV-2 Antibodies in a Cohort of Patients With Inflammatory Arthritis: The MAINSTREAM StudyWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-03-11Full publication date if available
- Authors
-
Ennio Giulio Favalli, Andrea Gobbini, Mauro Bombaci, Gabriella Maioli, Martina Biggioggero, Elisa Pesce, Andrea Favalli, Martina Martinović, Tanya Fabbris, Edoardo Marchisio, Alessandra Bandera, Andrea Gori, Sergio Abrignani, Renata Grifantini, Roberto CaporaliList of authors in order
- Landing page
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https://doi.org/10.3389/fmed.2022.850858Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fmed.2022.850858/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fmed.2022.850858/pdfDirect OA link when available
- Concepts
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Medicine, Seroprevalence, Antibody, Cohort, Immunology, Cohort study, Biological drugs, Serology, Internal medicine, Rheumatoid arthritisTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2024: 2, 2022: 2Per-year citation counts (last 5 years)
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27Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5081487159 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I189158943, https://openalex.org/I4210113750 |
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| sustainable_development_goals[0].display_name | Good health and well-being |
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| citation_normalized_percentile.is_in_top_10_percent | False |