The Impact of Ca2+ on Intracellular Distribution of Hemoglobin in Human Erythrocytes Article Swipe
Leonid Livshits
,
Sari Peretz
,
Anna Bogdanova
,
Hiba Zoabi
,
Harel Eitam
,
Gregory Barshtein
,
Cindy Galindo
,
Yuri Feldman
,
Ivana Pajić‐Lijaković
,
Ariel Koren
,
Max Gassmann
,
Carina Levin
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/cells12182280
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/cells12182280
The membrane-bound hemoglobin (Hb) fraction impacts red blood cell (RBC) rheology and metabolism. Therefore, Hb–RBC membrane interactions are precisely controlled. For instance, the signaling function of membrane-bound deoxy-Hb and the structure of the docking sites in the cytosolic domain of the anion exchanger 1 (AE-1) protein are well documented; however, much less is known about the interaction of Hb variants with the erythrocyte’s membrane. Here, we identified factors other than O2 availability that control Hb abundance in the membrane-bound fraction and the possible variant-specific binding selectivity of Hb to the membrane. We show that depletion of extracellular Ca2+ by chelators, or its omission from the extracellular medium, leads to membrane-bound Hb release into the cytosol. The removal of extracellular Ca2+ further triggers the redistribution of HbA0 and HbA2 variants between the membrane and the cytosol in favor of membrane-bound HbA2. Both effects are reversible and are no longer observed upon reintroduction of Ca2+ into the extracellular medium. Fluctuations of cytosolic Ca2+ also impact the pre-membrane Hb pool, resulting in the massive transfer of Hb to the cellular cytosol. We hypothesize that AE-1 is the specific membrane target and discuss the physiological outcomes and possible clinical implications of the Ca2+ regulation of the intracellular Hb distribution.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells12182280
- OA Status
- gold
- Cited By
- 9
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386781742
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386781742Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cells12182280Digital Object Identifier
- Title
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The Impact of Ca2+ on Intracellular Distribution of Hemoglobin in Human ErythrocytesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-09-15Full publication date if available
- Authors
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Leonid Livshits, Sari Peretz, Anna Bogdanova, Hiba Zoabi, Harel Eitam, Gregory Barshtein, Cindy Galindo, Yuri Feldman, Ivana Pajić‐Lijaković, Ariel Koren, Max Gassmann, Carina LevinList of authors in order
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https://doi.org/10.3390/cells12182280Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/cells12182280Direct OA link when available
- Concepts
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Cytosol, Extracellular, Intracellular, Membrane, Biophysics, Chemistry, Red blood cell, Cell membrane, Biochemistry, Hemoglobin, Membrane protein, Cell biology, Biology, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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9Total citation count in OpenAlex
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2025: 5, 2024: 4Per-year citation counts (last 5 years)
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53Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.of | 25, 31, 39, 57, 86, 95, 117, 124, 137, 151, 158, 172, 196, 200 |
| abstract_inverted_index.or | 100 |
| abstract_inverted_index.to | 88, 108, 174 |
| abstract_inverted_index.we | 65 |
| abstract_inverted_index.For | 20 |
| abstract_inverted_index.The | 0, 115 |
| abstract_inverted_index.and | 11, 28, 80, 126, 132, 144, 187, 192 |
| abstract_inverted_index.are | 17, 46, 142, 145 |
| abstract_inverted_index.its | 101 |
| abstract_inverted_index.red | 6 |
| abstract_inverted_index.the | 22, 29, 32, 36, 40, 55, 61, 77, 81, 89, 104, 113, 122, 130, 133, 154, 163, 169, 175, 183, 189, 197, 201 |
| abstract_inverted_index.(Hb) | 3 |
| abstract_inverted_index.AE-1 | 181 |
| abstract_inverted_index.Both | 140 |
| abstract_inverted_index.Ca2+ | 97, 119, 152, 160, 198 |
| abstract_inverted_index.HbA0 | 125 |
| abstract_inverted_index.HbA2 | 127 |
| abstract_inverted_index.also | 161 |
| abstract_inverted_index.cell | 8 |
| abstract_inverted_index.from | 103 |
| abstract_inverted_index.into | 112, 153 |
| abstract_inverted_index.less | 51 |
| abstract_inverted_index.much | 50 |
| abstract_inverted_index.show | 92 |
| abstract_inverted_index.than | 69 |
| abstract_inverted_index.that | 72, 93, 180 |
| abstract_inverted_index.upon | 149 |
| abstract_inverted_index.well | 47 |
| abstract_inverted_index.with | 60 |
| abstract_inverted_index.(RBC) | 9 |
| abstract_inverted_index.HbA2. | 139 |
| abstract_inverted_index.Here, | 64 |
| abstract_inverted_index.about | 54 |
| abstract_inverted_index.anion | 41 |
| abstract_inverted_index.blood | 7 |
| abstract_inverted_index.favor | 136 |
| abstract_inverted_index.known | 53 |
| abstract_inverted_index.leads | 107 |
| abstract_inverted_index.other | 68 |
| abstract_inverted_index.pool, | 166 |
| abstract_inverted_index.sites | 34 |
| abstract_inverted_index.(AE-1) | 44 |
| abstract_inverted_index.domain | 38 |
| abstract_inverted_index.impact | 162 |
| abstract_inverted_index.longer | 147 |
| abstract_inverted_index.target | 186 |
| abstract_inverted_index.between | 129 |
| abstract_inverted_index.binding | 84 |
| abstract_inverted_index.control | 73 |
| abstract_inverted_index.cytosol | 134 |
| abstract_inverted_index.discuss | 188 |
| abstract_inverted_index.docking | 33 |
| abstract_inverted_index.effects | 141 |
| abstract_inverted_index.factors | 67 |
| abstract_inverted_index.further | 120 |
| abstract_inverted_index.impacts | 5 |
| abstract_inverted_index.massive | 170 |
| abstract_inverted_index.medium, | 106 |
| abstract_inverted_index.medium. | 156 |
| abstract_inverted_index.protein | 45 |
| abstract_inverted_index.release | 111 |
| abstract_inverted_index.removal | 116 |
| abstract_inverted_index.Hb–RBC | 14 |
| abstract_inverted_index.cellular | 176 |
| abstract_inverted_index.clinical | 194 |
| abstract_inverted_index.cytosol. | 114, 177 |
| abstract_inverted_index.deoxy-Hb | 27 |
| abstract_inverted_index.fraction | 4, 79 |
| abstract_inverted_index.function | 24 |
| abstract_inverted_index.however, | 49 |
| abstract_inverted_index.membrane | 15, 131, 185 |
| abstract_inverted_index.observed | 148 |
| abstract_inverted_index.omission | 102 |
| abstract_inverted_index.outcomes | 191 |
| abstract_inverted_index.possible | 82, 193 |
| abstract_inverted_index.rheology | 10 |
| abstract_inverted_index.specific | 184 |
| abstract_inverted_index.transfer | 171 |
| abstract_inverted_index.triggers | 121 |
| abstract_inverted_index.variants | 59, 128 |
| abstract_inverted_index.abundance | 75 |
| abstract_inverted_index.cytosolic | 37, 159 |
| abstract_inverted_index.depletion | 94 |
| abstract_inverted_index.exchanger | 42 |
| abstract_inverted_index.instance, | 21 |
| abstract_inverted_index.membrane. | 63, 90 |
| abstract_inverted_index.precisely | 18 |
| abstract_inverted_index.resulting | 167 |
| abstract_inverted_index.signaling | 23 |
| abstract_inverted_index.structure | 30 |
| abstract_inverted_index.Therefore, | 13 |
| abstract_inverted_index.chelators, | 99 |
| abstract_inverted_index.hemoglobin | 2 |
| abstract_inverted_index.identified | 66 |
| abstract_inverted_index.regulation | 199 |
| abstract_inverted_index.reversible | 143 |
| abstract_inverted_index.controlled. | 19 |
| abstract_inverted_index.documented; | 48 |
| abstract_inverted_index.hypothesize | 179 |
| abstract_inverted_index.interaction | 56 |
| abstract_inverted_index.metabolism. | 12 |
| abstract_inverted_index.selectivity | 85 |
| abstract_inverted_index.Fluctuations | 157 |
| abstract_inverted_index.availability | 71 |
| abstract_inverted_index.implications | 195 |
| abstract_inverted_index.interactions | 16 |
| abstract_inverted_index.pre-membrane | 164 |
| abstract_inverted_index.distribution. | 204 |
| abstract_inverted_index.extracellular | 96, 105, 118, 155 |
| abstract_inverted_index.intracellular | 202 |
| abstract_inverted_index.physiological | 190 |
| abstract_inverted_index.membrane-bound | 1, 26, 78, 109, 138 |
| abstract_inverted_index.redistribution | 123 |
| abstract_inverted_index.reintroduction | 150 |
| abstract_inverted_index.erythrocyte’s | 62 |
| abstract_inverted_index.variant-specific | 83 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5033276770 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I202697423, https://openalex.org/I2799294462 |
| citation_normalized_percentile.value | 0.85986492 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |