The Impact of Liver Resection Volume on Pancreatic Function: Novel Insights into Acute Liver-Pancreas Crosstalk After Hepatectomy Article Swipe
Taiichi Wakiya
,
Yasunaru Sakuma
,
Yasuharu Onishi
,
Yukihiro Sanada
,
Noriki Okada
,
Yuta Hirata
,
Toshio Horiuchi
,
Takahiko Omameuda
,
Kiichiro Takadera
,
Naohiro Sata
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3612408/v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3612408/v1
The liver and pancreas work together to recover homeostasis after hepatectomy. This study aimed to investigate the effect of liver resection volume on the pancreas. We collected clinical data from 338 living liver donors. They were categorized into left lateral sectionectomy (LLS), left lobectomy, and right lobectomy (RL) groups. Serum pancreatic enzymes were compared among the groups. Serum amylase values peaked on postoperative day (POD) 1. Though they quickly returned to preoperative levels on POD 3, 45% of cases showed abnormal values on POD 7 in the RL group. Serum lipase levels were highest at POD 7. Lipase values increased 4.2-fold on POD 7 in the RL group and 80% of cases showed abnormal values. The RL group’s lipase was twice that of the LLS group. A negative correlation existed between the remnant liver volume and amylase (r = -0.291)/lipase (r = -0.380) on POD 7. Furthermore, a significant correlation was observed between POD 7 serum bilirubin and amylase (r = 0.245)/lipase (r = 0.330) levels, indicating cooccurrence with liver and pancreatic dysfunction. Pancreatic dysfunction due to hepatectomy occurs in a resection/remnant liver volume-dependent manner. It would be beneficial to closely monitor pancreatic function in patients undergoing a major hepatectomy.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-3612408/v1
- https://www.researchsquare.com/article/rs-3612408/latest.pdf
- OA Status
- green
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388824211
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4388824211Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-3612408/v1Digital Object Identifier
- Title
-
The Impact of Liver Resection Volume on Pancreatic Function: Novel Insights into Acute Liver-Pancreas Crosstalk After HepatectomyWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-11-20Full publication date if available
- Authors
-
Taiichi Wakiya, Yasunaru Sakuma, Yasuharu Onishi, Yukihiro Sanada, Noriki Okada, Yuta Hirata, Toshio Horiuchi, Takahiko Omameuda, Kiichiro Takadera, Naohiro SataList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-3612408/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-3612408/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-3612408/latest.pdfDirect OA link when available
- Concepts
-
Hepatectomy, Lipase, Amylase, Pancreas, Internal medicine, Medicine, Liver function, Gastroenterology, Resection, Endocrinology, Biology, Surgery, Enzyme, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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41Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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