The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway Article Swipe
Hong Chang Tan
,
Jean W. Hsu
,
E Shyong Tai
,
Shaji Chacko
,
Jean‐Paul Kovalik
,
Farook Jahoor
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2024.1343738
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2024.1343738
Background Glycine is an integral component of the human detoxification system as it reacts with potentially toxic exogenous and endogenously produced compounds and metabolites via the glycine conjugation pathway for urinary excretion. Because individuals with obesity have reduced glycine availability, this detoxification pathway may be compromised. However, it should be restored after bariatric surgery because of increased glycine production. Objective To examine the impact of obesity-associated glycine deficiency on the glycine conjugation pathway. We hypothesize that the synthesis rates of acylglycines from endogenous and exogenous sources are significantly reduced in individuals with obesity but increase after bariatric surgery. Methods We recruited 21 participants with class III obesity and 21 with healthy weight as controls. At baseline, [1,2- 13 C 2 ] glycine was infused to study the glycine conjugation pathway by quantifying the synthesis rates of several acylglycines. The same measurements were repeated in participants with obesity six months after bariatric surgery. Data are presented as mean ± standard deviation, and p -value< 0.05 is considered statistically significant. Results Baseline data of 20 participants with obesity were first compared to controls. Participants with obesity were significantly heavier than controls (mean BMI 40.5 ± 7.1 vs. 20.8 ± 2.1 kg/m 2 ). They had significantly lower plasma glycine concentration (168 ± 30 vs. 209 ± 50 μmol/L) and slower absolute synthesis rates of acetylglycine, isobutyrylglycine, tigylglycine, isovalerylglycine, and hexanoylglycine. Pre- and post-surgery data were available for 16 participants with obesity. Post-surgery BMI decreased from 40.9 ± 7.3 to 31.6 ± 6.0 kg/m 2 . Plasma glycine concentration increased from 164 ± 26 to 212 ± 38 μmol/L) and was associated with significantly higher rates of excretion of acetylglycine, isobutyrylglycine, tigylglycine, isovalerylglycine, and hexanoylglycine. Benzoic acid (a xenobiotic dicarboxylic acid) is excreted as benzoylglycine; its synthesis rate was significantly slower in participants with obesity but increased after bariatric surgery. Conclusion Obesity-associated glycine deficiency impairs the human body’s ability to eliminate endogenous and exogenous metabolites/compounds via the glycine conjugation pathway. This impairment is ameliorated when glycine supply is restored after bariatric surgery. These findings imply that dietary glycine supplementation could treat obesity-associated metabolic complications due to the accumulation of intramitochondrial toxic metabolites. Clinical trial registration https://clinicaltrials.gov/study/NCT04660513 , identifier NCT04660513.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2024.1343738
- https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1343738/pdf
- OA Status
- gold
- Cited By
- 11
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393862193
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393862193Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fendo.2024.1343738Digital Object Identifier
- Title
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The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathwayWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-03Full publication date if available
- Authors
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Hong Chang Tan, Jean W. Hsu, E Shyong Tai, Shaji Chacko, Jean‐Paul Kovalik, Farook JahoorList of authors in order
- Landing page
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https://doi.org/10.3389/fendo.2024.1343738Publisher landing page
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https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1343738/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1343738/pdfDirect OA link when available
- Concepts
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Glycine, Obesity, Detoxification (alternative medicine), Endogeny, Urinary system, Medicine, Endocrinology, Internal medicine, Weight loss, Excretion, Chemistry, Amino acid, Biochemistry, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
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11Total citation count in OpenAlex
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2025: 10, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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32Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.body’s | 314 |
| abstract_inverted_index.compared | 178 |
| abstract_inverted_index.controls | 188 |
| abstract_inverted_index.excreted | 289 |
| abstract_inverted_index.findings | 340 |
| abstract_inverted_index.increase | 94 |
| abstract_inverted_index.integral | 4 |
| abstract_inverted_index.obesity. | 238 |
| abstract_inverted_index.pathway. | 72, 326 |
| abstract_inverted_index.produced | 20 |
| abstract_inverted_index.repeated | 142 |
| abstract_inverted_index.restored | 50, 335 |
| abstract_inverted_index.standard | 158 |
| abstract_inverted_index.surgery. | 97, 151, 306, 338 |
| abstract_inverted_index.μmol/L) | 215, 265 |
| abstract_inverted_index.Objective | 59 |
| abstract_inverted_index.available | 233 |
| abstract_inverted_index.bariatric | 52, 96, 150, 305, 337 |
| abstract_inverted_index.baseline, | 115 |
| abstract_inverted_index.component | 5 |
| abstract_inverted_index.compounds | 21 |
| abstract_inverted_index.controls. | 113, 180 |
| abstract_inverted_index.decreased | 241 |
| abstract_inverted_index.eliminate | 317 |
| abstract_inverted_index.excretion | 274 |
| abstract_inverted_index.exogenous | 17, 84, 320 |
| abstract_inverted_index.increased | 56, 256, 303 |
| abstract_inverted_index.metabolic | 349 |
| abstract_inverted_index.presented | 154 |
| abstract_inverted_index.recruited | 100 |
| abstract_inverted_index.synthesis | 77, 133, 219, 293 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Conclusion | 307 |
| abstract_inverted_index.associated | 268 |
| abstract_inverted_index.considered | 165 |
| abstract_inverted_index.deficiency | 67, 310 |
| abstract_inverted_index.deviation, | 159 |
| abstract_inverted_index.endogenous | 82, 318 |
| abstract_inverted_index.excretion. | 31 |
| abstract_inverted_index.identifier | 364 |
| abstract_inverted_index.impairment | 328 |
| abstract_inverted_index.xenobiotic | 285 |
| abstract_inverted_index.ameliorated | 330 |
| abstract_inverted_index.conjugation | 27, 71, 128, 325 |
| abstract_inverted_index.hypothesize | 74 |
| abstract_inverted_index.individuals | 33, 90 |
| abstract_inverted_index.metabolites | 23 |
| abstract_inverted_index.potentially | 15 |
| abstract_inverted_index.production. | 58 |
| abstract_inverted_index.quantifying | 131 |
| abstract_inverted_index.NCT04660513. | 365 |
| abstract_inverted_index.Participants | 181 |
| abstract_inverted_index.Post-surgery | 239 |
| abstract_inverted_index.accumulation | 354 |
| abstract_inverted_index.acylglycines | 80 |
| abstract_inverted_index.compromised. | 45 |
| abstract_inverted_index.dicarboxylic | 286 |
| abstract_inverted_index.endogenously | 19 |
| abstract_inverted_index.measurements | 140 |
| abstract_inverted_index.metabolites. | 358 |
| abstract_inverted_index.participants | 102, 144, 173, 236, 299 |
| abstract_inverted_index.post-surgery | 230 |
| abstract_inverted_index.registration | 361 |
| abstract_inverted_index.significant. | 167 |
| abstract_inverted_index.acylglycines. | 137 |
| abstract_inverted_index.availability, | 39 |
| abstract_inverted_index.complications | 350 |
| abstract_inverted_index.concentration | 207, 255 |
| abstract_inverted_index.significantly | 87, 185, 203, 270, 296 |
| abstract_inverted_index.statistically | 166 |
| abstract_inverted_index.tigylglycine, | 224, 278 |
| abstract_inverted_index.-value&lt; | 162 |
| abstract_inverted_index.acetylglycine, | 222, 276 |
| abstract_inverted_index.detoxification | 9, 41 |
| abstract_inverted_index.benzoylglycine; | 291 |
| abstract_inverted_index.supplementation | 345 |
| abstract_inverted_index.hexanoylglycine. | 227, 281 |
| abstract_inverted_index.Obesity-associated | 308 |
| abstract_inverted_index.intramitochondrial | 356 |
| abstract_inverted_index.isobutyrylglycine, | 223, 277 |
| abstract_inverted_index.isovalerylglycine, | 225, 279 |
| abstract_inverted_index.obesity-associated | 65, 348 |
| abstract_inverted_index.metabolites/compounds | 321 |
| abstract_inverted_index.https://clinicaltrials.gov/study/NCT04660513 | 362 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5065273742 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I2251586001 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.4399999976158142 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.95550459 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |