The impact of spleen metabolic tumor volume on total metabolic tumor volume and prognosis in patients with follicular lymphoma enrolled in FOLL 12 trial Article Swipe
Luca Guerra
,
Stéphane Chauvie
,
Luigi Marcheselli
,
Fabrizio Bergesio
,
Rexhep Durmo
,
S. Peano
,
Antonella Franceschetto
,
Federico Fallanca
,
Antonio Pinto
,
Chiara Ghiggi
,
Alessandro Pulsoni
,
Michele Merli
,
Lucia Farina
,
Monica Tani
,
Carola Boccomini
,
Gerardo Musuraca
,
Brunangelo Falini
,
Filippo Ballerini
,
Piero Maria Stefani
,
Silvia Bolis
,
Giuseppe Pietrantuono
,
Martina Manni
,
Massimo Federico
,
Stefano Luminari
,
Annibale Versari
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/hon.3164_242
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/hon.3164_242
Introduction and Aim: Recently, in an ancillary study of FOLL12 trial (NCT02063685), total Metabolic Tumor Volume (tMTV) assessed before treatment has been demonstrated to be an independent predictor of PFS in patients receiving frontline immune chemotherapy (1). During the segmentation procedure, it has been observed that frequently spleen MTV (sMTV) heavily influenced the tMTV value, particularly in case of diffuse spleen uptake included in tMTV calculation. High tMTV could be a negative prognostic factor as it represents the tumor burden. On this basis, the aim of the current study was to evaluate the effect of the sMTV defined on baseline PET on tMTV calculation and its impact on outcome, particularly 5y-PFS (Progression Free Survival), in follicular lymphoma patients. Methods and Results: Overall, 690 patients with baseline PET were included in the analysis, 48% were older than 60 years, 89% had stage III-IV disease and 40% had a high-risk FLIPI-2 score. Overall, the 5y-PFS was 79% (95% CI, 76%–82%). Among 690 patients 469 (67.9%) did not have spleen involvement while 128 (18.5%) and 93 (13.4%) showed focal and diffuse spleen involvement, respectively. The 5y-PFS (95% CI) according the spleen status was 67% (62–72), 58% (48–67) and 61% (49–61) in patients without, with focal and with diffuse spleen involvement, respectively (p not significant). MTV calculation was performed with a threshold of 41% for segmentation. In the whole population of 690 patients, the tMTV threshold to categorized low and high tumor burden was 224 and 194 ml with and without sMTV, respectively. Assuming 200 ml as a tMTV threshold, only 16/693 pts (2.3%) changed from low to high tumor burden when the sMTV was included in the tMTV. Including sMTV in tMTV, with a threshold of 200 ml, the 5y-PFS in patients with low and high tMTV was 73% (95% CI: 67–78) and 58% (95% CI: 53–64), respectively, with a HR of 1.83 (p < 0.001). Excluding sMTV from tMTV, the 5y-PFS in patients with low and high tMTV was 72% (95% CI: 67–77) and 58% (95% CI: 52–64) with a HR of 1.80 (p < 0.001). In the two groups, HRs values for tMTV >200 ml showed negligible difference, independently from sMTV inclusion. Conclusion: These preliminary data of the FOLL12 trial showed that tMTV correlated with outcome in terms of PFS; on the contrary the metabolic spleen status defined in the baseline PET do not seem to show any prognostic added value, neither in case of focal nor in case of diffuse uptake. Finally, the inclusion/exclusion of the sMTV into the tMTV did not significantly change either the risk classification of the patients or the outcome in terms of PFS. Larger patients population are needed to confirm these data. References: R. Durmo, L. Guerra, S. Chauvie et al. "Total Metabolic Tumor Volume and tumor dissemination calculated from PET/CT scan before first line therapy are predictors of outcome in patients with follicular lymphoma" Eur J Nucl Med Mol Imaging (2022) 49 (Suppl 1): S1–S751; OP 629 Keywords: Diagnostic and Prognostic Biomarkers, PET-CT No conflicts of interests pertinent to the abstract.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/hon.3164_242
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.3164_242
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4379981744
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4379981744Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/hon.3164_242Digital Object Identifier
- Title
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The impact of spleen metabolic tumor volume on total metabolic tumor volume and prognosis in patients with follicular lymphoma enrolled in FOLL 12 trialWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-06-01Full publication date if available
- Authors
-
Luca Guerra, Stéphane Chauvie, Luigi Marcheselli, Fabrizio Bergesio, Rexhep Durmo, S. Peano, Antonella Franceschetto, Federico Fallanca, Antonio Pinto, Chiara Ghiggi, Alessandro Pulsoni, Michele Merli, Lucia Farina, Monica Tani, Carola Boccomini, Gerardo Musuraca, Brunangelo Falini, Filippo Ballerini, Piero Maria Stefani, Silvia Bolis, Giuseppe Pietrantuono, Martina Manni, Massimo Federico, Stefano Luminari, Annibale VersariList of authors in order
- Landing page
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https://doi.org/10.1002/hon.3164_242Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.3164_242Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.3164_242Direct OA link when available
- Concepts
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Medicine, Spleen, Follicular lymphoma, Internal medicine, Gastroenterology, Lymphoma, Population, Oncology, Chemotherapy, Urology, Pathology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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