The impact of thrombo‐inflammation on the cerebral microcirculation Article Swipe
Junaid Ansari
,
Felicity N. E. Gavins
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/micc.12689
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/micc.12689
The intertwined processes of thrombosis and inflammation (termed “thrombo‐inflammation”) are significant drivers of cerebrovascular diseases, and as such, they represent prime targets for drug discovery programs focusing on treatment and management of cerebrovascular diseases. Most cerebrovascular events result from chronic systemic microcirculatory dysfunction due to underlying conditions, for example, hypertension, diabetes mellitus, coronary artery disease, dyslipidemia, and sickle cell disease. Immune cells especially neutrophils play a critical role in the onset and maintenance of neuroinflammatory responses in the microcirculation. Neutrophils have the ability to drive both inflammatory and anti‐inflammatory/pro‐resolution effects depending on the underlying vascular state (physiological vs. pathological). In this article, we highlight the pathophysiological role of neutrophils in stroke and discuss ongoing pharmacotherapeutic strategies that are focused on identifying potential therapeutic targets for enhancing neuroprotection, mitigating inflammatory pathways, and enabling resolution.
Related Topics
Concepts
Inflammation
Medicine
Microcirculation
Neuroprotection
Dyslipidemia
Stroke (engine)
Disease
Diabetes mellitus
Thrombosis
Coronary artery disease
Neuroinflammation
Immune system
Neuroscience
Immunology
Bioinformatics
Cardiology
Internal medicine
Biology
Mechanical engineering
Engineering
Endocrinology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/micc.12689
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/micc.12689
- OA Status
- bronze
- Cited By
- 14
- References
- 125
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3130835871
All OpenAlex metadata
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https://openalex.org/W3130835871Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/micc.12689Digital Object Identifier
- Title
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The impact of thrombo‐inflammation on the cerebral microcirculationWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-02-27Full publication date if available
- Authors
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Junaid Ansari, Felicity N. E. GavinsList of authors in order
- Landing page
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https://doi.org/10.1111/micc.12689Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/micc.12689Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/micc.12689Direct OA link when available
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Inflammation, Medicine, Microcirculation, Neuroprotection, Dyslipidemia, Stroke (engine), Disease, Diabetes mellitus, Thrombosis, Coronary artery disease, Neuroinflammation, Immune system, Neuroscience, Immunology, Bioinformatics, Cardiology, Internal medicine, Biology, Mechanical engineering, Engineering, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 3, 2023: 3, 2022: 3, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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125Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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