The Implantable System That Restores Hemodynamic Stability After Spinal Cord Injury Article Swipe
YOU?
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· 2024
· Open Access
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· DOI: https://doi.org/10.1101/2024.05.10.24306826
A spinal cord injury (SCI) causes immediate and sustained hemodynamic instability that threatens neurological recovery and impacts quality of life. Here, we establish the clinical burden of chronic hypotensive complications due to SCI in 1,479 participants, and expose the ineffective treatment of these complications with conservative measures. To address this clinical burden, we developed a purpose-built implantable system based on biomimetic epidural electrical stimulation (EES) of the spinal cord that immediately triggered robust pressor responses. The system durably reduced the severity of hypotensive complications in people with SCI, removed the necessity for conservative treatments, improved quality of life, and enabled engagement in activities of daily living. Central to the development of this therapy was the head-to-head demonstration in the same participants that EES must target the last three thoracic segments, and not the lumbosacral segments, to achieve the safe and effective regulation of blood pressure in people with SCI. These findings in 14 participants establish a path for a pivotal device trial that evaluates the safety and efficacy of EES to treat the underappreciated, treatment-resistant hypotensive complications due to SCI.
Related Topics
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.05.10.24306826
- https://www.medrxiv.org/content/medrxiv/early/2024/05/15/2024.05.10.24306826.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 63
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4396830413Canonical identifier for this work in OpenAlex
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https://doi.org/10.1101/2024.05.10.24306826Digital Object Identifier
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The Implantable System That Restores Hemodynamic Stability After Spinal Cord InjuryWork title
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-10Full publication date if available
- Authors
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Aaron A. Phillips, Aasta P. Gandhi, Nicolas Hankov, Sergio Daniel Hernandez‐Charpak, Julien Rimok, Anthony V. Incognito, Anouk E.J. Nijland, Marina D’Ercole, Anne Watrin, Maxime Berney, Aikaterini Damianaki, Grégory Dumont, Nicolò Macellari, Laura De Herde, Nadine Intering, Donovan Smith, Ryan Miller, M. Smith, Jordan Lee, Edeny Baaklini, Jean‐Baptiste Ledoux, Javier G. Ordonnez, Taylor Newton, Ettore Flavio Meliadò, Léa Duguet, Charlotte Jacquet, Léa Bole-Feysot, Markus Rieger, Kristen Gelenitis, Yoann Dumeny, Miroslav Caban, Damien Ganty, Edoardo Paoles, Thomas G. Baumgartner, Cathal Harte, Charles David Sasportes, Paul Romo, Tristan Vouga, Jemina Fasola, Jimmy Ravier, Matthieu Gautier, Frédéric Merlos, Rik Buschman, Tomislav Milekovic, Andreas Rowald, Stefano Mandija, Cornelis A. T. van den Berg, Niels Kuster, Esra Neufeld, Étienne Pralong, Lorenz Hirt, Stefano Carda, Fabio Becce, É. Aleton, Kyle Rogan, Patrick Schoettker, Grégoire Wuerzner, Nelleke G. Langerak, Noël Keijsers, Brian K. Kwon, James D. Guest, Erika Ross, John Murphy, Erkan Kurt, Steve Casha, Fady Girgis, Ilse J. W. van Nes, Kelly A. Larkin-Kaiser, Robin Demesmaeker, Léonie Asboth, Jordan W. Squair, Jocelyne Bloch, Grégoire CourtineList of authors in order
- Landing page
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- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2024/05/15/2024.05.10.24306826.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.medrxiv.org/content/medrxiv/early/2024/05/15/2024.05.10.24306826.full.pdfDirect OA link when available
- Concepts
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Spinal cord injury, Hemodynamics, Spinal cord, Anesthesia, Medicine, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1Per-year citation counts (last 5 years)
- References (count)
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63Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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