The influence of baseline clinical status and surgical strategy on early good to excellent result in spinal lumbar arthrodesis: a machine learning approach Article Swipe
Francesco Langella
,
Luca Ventriglia
,
Domenico Compagnone
,
Paolo Barletta
,
David Huber
,
Francesca Mangili
,
Ginevra Licandro
,
Fabio Galbusera
,
Andrea Cina
,
Tito Bassani
,
Claudio Lamartina
,
Laura Scaramuzzo
,
Roberto Bassani
,
Marco Brayda‐Bruno
,
Jorge Hugo Villafañe
,
Pedro Berjano
,
Laura Azzimonti
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.09.17.21263625
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.09.17.21263625
Aims To create, using a machine learning (ML) approach, a preoperative model from baseline demographic and health-related quality of life scores (HRQOL) to predict a good to excellent early clinical outcome. Patients and Methods A single spine surgery center retrospective review of prospectively collected data from January 2016 to December 2020 from the institutional registry (SpineREG) was performed. The inclusion criteria were age ≥ 18 years, both sexes, lumbar arthrodesis procedure, a complete follow up assessment (ODI, SF-36 and COMI back) and the capability to read and understand the Italian language. A delta of improvement of the ODI higher than 12.7/100 was considered a “good early outcome”. A combined target model of ODI (Δ ≥ 12.7/100), SF-36 PCS (Δ ≥ 6/100) and COMI back (Δ ≥ 2.2/10) was considered an “excellent early outcome”. The performance of the ML models was evaluated in terms of sensitivity, i.e., True Positive Rate (TPR), specificity, i.e., True Negative Rate (TNR), accuracy and area under the receiver operating characteristic curve (AUC ROC). Results A total of 1243 patients were included in this study. The model for predicting ODI at 6 months follow up showed a good balance between sensitivity (74.3%) and specificity (79.4%), while providing a good accuracy (75.8%) with ROC AUC = 0.842. The combined target model showed a sensitivity of 74.2% and specificity of 71.8%, with an accuracy of 72.8%, and a ROC AUC = 0.808. Conclusion The results of our study suggest that a machine learning approach showed high performance in predicting early good to excellent clinical results.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.09.17.21263625
- https://www.medrxiv.org/content/medrxiv/early/2021/09/22/2021.09.17.21263625.full.pdf
- OA Status
- green
- Cited By
- 8
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3200698379
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3200698379Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2021.09.17.21263625Digital Object Identifier
- Title
-
The influence of baseline clinical status and surgical strategy on early good to excellent result in spinal lumbar arthrodesis: a machine learning approachWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-22Full publication date if available
- Authors
-
Francesco Langella, Luca Ventriglia, Domenico Compagnone, Paolo Barletta, David Huber, Francesca Mangili, Ginevra Licandro, Fabio Galbusera, Andrea Cina, Tito Bassani, Claudio Lamartina, Laura Scaramuzzo, Roberto Bassani, Marco Brayda‐Bruno, Jorge Hugo Villafañe, Pedro Berjano, Laura AzzimontiList of authors in order
- Landing page
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https://doi.org/10.1101/2021.09.17.21263625Publisher landing page
- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2021/09/22/2021.09.17.21263625.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2021/09/22/2021.09.17.21263625.full.pdfDirect OA link when available
- Concepts
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Receiver operating characteristic, Arthrodesis, Medicine, Lumbar, Baseline (sea), Outcome (game theory), Physical therapy, Surgery, Internal medicine, Mathematics, Geology, Oceanography, Alternative medicine, Mathematical economics, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
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2025: 4, 2024: 1, 2023: 1, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Italian | 90 |
| abstract_inverted_index.January | 47 |
| abstract_inverted_index.Methods | 34 |
| abstract_inverted_index.Results | 168 |
| abstract_inverted_index.balance | 192 |
| abstract_inverted_index.between | 193 |
| abstract_inverted_index.create, | 3 |
| abstract_inverted_index.machine | 6, 243 |
| abstract_inverted_index.predict | 24 |
| abstract_inverted_index.quality | 18 |
| abstract_inverted_index.results | 236 |
| abstract_inverted_index.suggest | 240 |
| abstract_inverted_index.surgery | 38 |
| abstract_inverted_index.“good | 105 |
| abstract_inverted_index.(79.4%), | 198 |
| abstract_inverted_index.12.7/100 | 101 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.December | 50 |
| abstract_inverted_index.Negative | 154 |
| abstract_inverted_index.Patients | 32 |
| abstract_inverted_index.Positive | 148 |
| abstract_inverted_index.accuracy | 157, 203, 225 |
| abstract_inverted_index.approach | 245 |
| abstract_inverted_index.baseline | 14 |
| abstract_inverted_index.clinical | 30, 255 |
| abstract_inverted_index.combined | 109, 211 |
| abstract_inverted_index.complete | 73 |
| abstract_inverted_index.criteria | 61 |
| abstract_inverted_index.included | 175 |
| abstract_inverted_index.learning | 7, 244 |
| abstract_inverted_index.outcome. | 31 |
| abstract_inverted_index.patients | 173 |
| abstract_inverted_index.receiver | 162 |
| abstract_inverted_index.registry | 55 |
| abstract_inverted_index.results. | 256 |
| abstract_inverted_index.approach, | 9 |
| abstract_inverted_index.collected | 44 |
| abstract_inverted_index.evaluated | 141 |
| abstract_inverted_index.excellent | 28, 254 |
| abstract_inverted_index.inclusion | 60 |
| abstract_inverted_index.language. | 91 |
| abstract_inverted_index.operating | 163 |
| abstract_inverted_index.providing | 200 |
| abstract_inverted_index.(SpineREG) | 56 |
| abstract_inverted_index.12.7/100), | 116 |
| abstract_inverted_index.Conclusion | 234 |
| abstract_inverted_index.assessment | 76 |
| abstract_inverted_index.capability | 84 |
| abstract_inverted_index.considered | 103, 129 |
| abstract_inverted_index.performed. | 58 |
| abstract_inverted_index.predicting | 182, 250 |
| abstract_inverted_index.procedure, | 71 |
| abstract_inverted_index.understand | 88 |
| abstract_inverted_index.arthrodesis | 70 |
| abstract_inverted_index.demographic | 15 |
| abstract_inverted_index.improvement | 95 |
| abstract_inverted_index.outcome”. | 107, 133 |
| abstract_inverted_index.performance | 135, 248 |
| abstract_inverted_index.sensitivity | 194, 216 |
| abstract_inverted_index.specificity | 197, 220 |
| abstract_inverted_index.preoperative | 11 |
| abstract_inverted_index.sensitivity, | 145 |
| abstract_inverted_index.specificity, | 151 |
| abstract_inverted_index.“excellent | 131 |
| abstract_inverted_index.institutional | 54 |
| abstract_inverted_index.prospectively | 43 |
| abstract_inverted_index.retrospective | 40 |
| abstract_inverted_index.characteristic | 164 |
| abstract_inverted_index.health-related | 17 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5079336039 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 17 |
| corresponding_institution_ids | https://openalex.org/I4210113215 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/4 |
| sustainable_development_goals[0].score | 0.5699999928474426 |
| sustainable_development_goals[0].display_name | Quality Education |
| citation_normalized_percentile.value | 0.67559437 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |