The influence of beam parameters on FLASH effect Article Swipe
Binwei Lin
,
Huan Du
,
Xiaofei Hao
,
Yuwen Liang
,
Haonan Xu
,
Wenqiang Tang
,
Jie Li
,
Yu Zhang
,
Xiaobo Du
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2025.1431700
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2025.1431700
Ultra-high dose rate radiotherapy (FLASH-RT) is typically defined as an external beam radiotherapy that utilizes a dose rate of 40 Gy/s or higher, compared with conventional dose rate radiotherapy (≤0.1 Gy/s). The primary advantage of FLASH-RT lies in its ability to minimize damage to organs at risk surrounding the cancer while preserving the anti-tumor effect. This phenomenon, known as the FLASH effect, has been widely studied in various bodily systems. However, recent publication of negative research findings related to FLASH-RT warrant a reassessment of whether this definition is accurate. Therefore, this review aims to critically examine how various beam parameters impact the manifestation of the FLASH effect. Following extensive literature review, we propose that an average dose rate of 40 Gy/s to be the lowest dose that triggers the FLASH effect. Beyond this threshold, different organs, including the brain, lungs, intestine, and skin, required varying minimum single total doses to trigger FLASH effects, with a trend of enhanced FLASH-RT protective effects as the single total doses increased. Moreover, single or multiple pulses and the characteristic parameters of the pulse structure, including single pulse dosage, pulse width, pulse interval, pulse frequency, and total irradiation time, were found to also impact the FLASH effect.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2025.1431700
- https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1431700/pdf
- OA Status
- gold
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409688801
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409688801Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2025.1431700Digital Object Identifier
- Title
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The influence of beam parameters on FLASH effectWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-22Full publication date if available
- Authors
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Binwei Lin, Huan Du, Xiaofei Hao, Yuwen Liang, Haonan Xu, Wenqiang Tang, Jie Li, Yu Zhang, Xiaobo DuList of authors in order
- Landing page
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https://doi.org/10.3389/fonc.2025.1431700Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1431700/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1431700/pdfDirect OA link when available
- Concepts
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Flash (photography), Radiation therapy, Pulse (music), Medicine, Dose rate, Irradiation, External beam radiotherapy, Nuclear medicine, Beam (structure), Pulse rate, Optics, Physics, Surgery, Internal medicine, Medical physics, Brachytherapy, Detector, Blood pressure, Nuclear physicsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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