The ingenious mast cell: Contemporary insights into mast cell behavior and function Article Swipe

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Joakim S. Dahlin , Marcus Maurer , Dean D. Metcalfe , Gunnar Pejler , Ronit Sagi‐Eisenberg , Gunnar Nilsson ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1111/all.14881

Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are important for homeostasis and surveillance of the human system, recognizing both endogenous and exogenous agents, which induce release of a variety of mediators acting on both immune and non‐immune cells, including nerve cells, fibroblasts, endothelial cells, smooth muscle cells, and epithelial cells. During recent years, clinical and experimental studies on human mast cells, as well as experiments using animal models, have resulted in many discoveries that help decipher the function of mast cells in health and disease. In this review, we focus particularly on new insights into mast cell biology, with a focus on mast cell development, recruitment, heterogeneity, and reactivity. We also highlight the development in our understanding of mast cell‐driven diseases and discuss the development of novel strategies to treat such conditions.

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Mast cell Mast (botany) Cell Function (biology) Immunology Biology Cell biology Genetics

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Type: review
Language: en
Landing Page: https://doi.org/10.1111/all.14881
PDF: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14881
OA Status: bronze
Cited By: 138
References: 185
Related Works: 10
OpenAlex ID: https://openalex.org/W3158828664

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OpenAlex ID: https://openalex.org/W3158828664

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DOI: https://doi.org/10.1111/all.14881

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Title: The ingenious mast cell: Contemporary insights into mast cell behavior and function

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Type: review

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Language: en

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Publication year: 2021

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Publication date: 2021-05-06

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Authors: Joakim S. Dahlin, Marcus Maurer, Dean D. Metcalfe, Gunnar Pejler, Ronit Sagi‐Eisenberg, Gunnar Nilsson

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Landing page: https://doi.org/10.1111/all.14881

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PDF URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14881

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OA status: bronze

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OA URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14881

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Concepts: Mast cell, Mast (botany), Cell, Function (biology), Immunology, Biology, Cell biology, Genetics

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Cited by: 138

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Citations by year (recent): 2025: 24, 2024: 42, 2023: 34, 2022: 28, 2021: 9

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References (count): 185

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