The Insertion Sequence Excision Enhancer (IEE): a PrimPol-based system for Immobilizing Transposon-Transmitted Antibiotic Resistance Genes? Article Swipe
Michaël Chandler
,
Karen Ross
,
Alessandro M. Varani
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.06.07.543989
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.06.07.543989
We provide an overview of a protein, IEE (Insertion Sequence Excision Enhancer), which was originally observed to facilitate high levels of excision of the IS3 family member, IS629, from clinically important Escherichia coli O157:H7. IEE was subsequently shown to affect a large class of bacterial insertion sequences which all transpose by producing a circular intermediate and presumably use the copy-out-paste-in transposition mechanism. Excision is dependent on both IEE and transposase indicating that it is associated with the transposition process itself. We propose that IEE serves to immobilize genes carried by compound transposons by removing the flanking IS copies, an activity which would explain the presence of certain of these genes without associated IS copies in plasmids and chromosomes. The biochemical activities of IEE as a primase with the capacity to recognize microhomologies, together with the observation that its effect appears to be restricted to those IS families which probably use the copy-out-paste-in transposition pathway, suggests a strand switch mechanism during the copy-out step leading to abortive transposition. This reinforces the proposal made for understanding the loss of the IS 30 family member, IS Apl1 , which flanks the mcr -1 gene in the compound transposon Tn 6330 .
Related Topics
Concepts
Transposition (logic)
Transposable element
Transposase
Insertion sequence
Genetics
Plasmid
Gene
Enhancer
Biology
Insertion
Mutation
Mutant
Computer science
Transcription factor
Artificial intelligence
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.06.07.543989
- https://www.biorxiv.org/content/biorxiv/early/2023/06/07/2023.06.07.543989.full.pdf
- OA Status
- green
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4379653755
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4379653755Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2023.06.07.543989Digital Object Identifier
- Title
-
The Insertion Sequence Excision Enhancer (IEE): a PrimPol-based system for Immobilizing Transposon-Transmitted Antibiotic Resistance Genes?Work title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-07Full publication date if available
- Authors
-
Michaël Chandler, Karen Ross, Alessandro M. VaraniList of authors in order
- Landing page
-
https://doi.org/10.1101/2023.06.07.543989Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/06/07/2023.06.07.543989.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2023/06/07/2023.06.07.543989.full.pdfDirect OA link when available
- Concepts
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Transposition (logic), Transposable element, Transposase, Insertion sequence, Genetics, Plasmid, Gene, Enhancer, Biology, Insertion, Mutation, Mutant, Computer science, Transcription factor, Artificial intelligenceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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56Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W1985886752, https://openalex.org/W2149452073, https://openalex.org/W797697366, https://openalex.org/W1986051089, https://openalex.org/W2050228332, https://openalex.org/W4380182256, https://openalex.org/W2199537945, https://openalex.org/W2018039799, https://openalex.org/W113807278, https://openalex.org/W2125455549, https://openalex.org/W1946362544, https://openalex.org/W2005024992, https://openalex.org/W2162419202, https://openalex.org/W2111408706, https://openalex.org/W2061199407, https://openalex.org/W1985334271, https://openalex.org/W2081802943, https://openalex.org/W1976158809, https://openalex.org/W2105718967, https://openalex.org/W2161407606, https://openalex.org/W1980984965, https://openalex.org/W2078042340, https://openalex.org/W2127732228, https://openalex.org/W2756032018, https://openalex.org/W2036928425, https://openalex.org/W2589157531, https://openalex.org/W2789944246, https://openalex.org/W2518717259, https://openalex.org/W2606564392, https://openalex.org/W2118343042, https://openalex.org/W2099836442, https://openalex.org/W2147973644, https://openalex.org/W2064374186, https://openalex.org/W2041997436, https://openalex.org/W2036840040, https://openalex.org/W2039397215, https://openalex.org/W2048624015, https://openalex.org/W4318479631, https://openalex.org/W2125466823, https://openalex.org/W199544152, https://openalex.org/W2000264313, https://openalex.org/W2108800696, https://openalex.org/W1963862431, https://openalex.org/W2025447131, https://openalex.org/W1990793628, https://openalex.org/W2059384684, https://openalex.org/W2038662837, https://openalex.org/W1978526316, https://openalex.org/W2179036997, https://openalex.org/W2524156053, https://openalex.org/W2031036921, https://openalex.org/W2565807206, https://openalex.org/W2044892152, https://openalex.org/W4289344564, https://openalex.org/W3199541726, https://openalex.org/W867209643 |
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