The Interaction Mechanism of Intramuscular Gene Delivery Materials with Cell Membranes Article Swipe

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Zhanpeng Cui , Jiao Yang , Linyu Pu , Jianlin Chen , Ming Liu , James Tang , Gang Wang ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.3390/jfb14040219

It has been confirmed that skeletal muscle cells have the capability to receive foreign plasmid DNA (pDNA) and express functional proteins. This provides a promisingly applicable strategy for safe, convenient, and economical gene therapy. However, intramuscular pDNA delivery efficiency was not high enough for most therapeutic purposes. Some non-viral biomaterials, especially several amphiphilic triblock copolymers, have been shown to significantly improve intramuscular gene delivery efficiency, but the detailed process and mechanism are still not well understood. In this study, the molecular dynamics simulation method was applied to investigate the structure and energy changes of the material molecules, the cell membrane, and the DNA molecules at the atomic and molecular levels. From the results, the interaction process and mechanism of the material molecules with the cell membrane were revealed, and more importantly, the simulation results almost completely matched the previous experimental results. This study may help us design and optimize better intramuscular gene delivery materials for clinical applications.

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Gene delivery Materials science Membrane Mechanism (biology) Cell Biophysics Amphiphile DNA Nanotechnology Genetic enhancement Molecule Molecular dynamics Plasmid Cell membrane Gene Copolymer Polymer Chemistry Biology Biochemistry Organic chemistry Epistemology Composite material Philosophy Computational chemistry

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Type: article
Language: en
Landing Page: https://doi.org/10.3390/jfb14040219
PDF: https://www.mdpi.com/2079-4983/14/4/219/pdf?version=1681441281
OA Status: gold
Cited By: 1
References: 72
Related Works: 10
OpenAlex ID: https://openalex.org/W4365514750

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DOI: https://doi.org/10.3390/jfb14040219

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Title: The Interaction Mechanism of Intramuscular Gene Delivery Materials with Cell Membranes

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Language: en

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Publication year: 2023

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Publication date: 2023-04-14

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Authors: Zhanpeng Cui, Jiao Yang, Linyu Pu, Jianlin Chen, Ming Liu, James Tang, Gang Wang

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Landing page: https://doi.org/10.3390/jfb14040219

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Concepts: Gene delivery, Materials science, Membrane, Mechanism (biology), Cell, Biophysics, Amphiphile, DNA, Nanotechnology, Genetic enhancement, Molecule, Molecular dynamics, Plasmid, Cell membrane, Gene, Copolymer, Polymer, Chemistry, Biology, Biochemistry, Organic chemistry, Epistemology, Composite material, Philosophy, Computational chemistry

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Cited by: 1

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