The interrelationship between cholinergic pathway in the magnocellular paraventricular nucleus and natriuresis Article Swipe
Chunyan Wang
,
Min Wang
,
Hengai Zhang
,
Xijia Deng
,
Pengxu Wang
,
Huizheng Mao
,
Yuan Shao Lin
,
Chunling Jiang
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.4149/gpb_2014042
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.4149/gpb_2014042
The central nervous system is known to play important roles in the regulation of renal sodium excretion. The present study was designed to reveal the interrelationship between cholinergic pathway in the magnocellular paraventricular nucleus (PVN) and the natriuresis induced by brain cholinergic stimuli. The results indicated that urinary sodium excretion was significantly increased at 40 min after intracerebroventricular (ICV) injection of carbachol (CBC). Immunohistochemical studies showed that CBC increased choline acetyltransferase-immunoreactivity (ChAT-IR) in the magnocellular PVN and renal proximal convoluted tubule (PCT), respectively. After pretreatment with atropine, urinary sodium excretion was significantly reduced, and carbachol-increased ChAT-IR in the magnocellular PVN and PCT was also significantly decreased. These results suggested that brain cholinergic stimuli induced the natriuresis and increased the activity of cholinergic neurons in the magnocellular PVN and cholinergic system in the PCT. The blockade of muscarinic receptor completely abolished the natriuresis and partially inhibited carbachol-exerted stimulatory effects in the magnocellular PVN and PCT. To summarize, brain cholinergic pathway and peripheral cholinergic system in kidney were found to contribute to the natriuresis following brain cholinergic stimulation. Our findings revealed novel evidence that PVN was involved in the natriuresis via humoral mechanisms.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4149/gpb_2014042
- http://www.elis.sk/download_file.php?product_id=4311&session_id=oebeqiu4l9tn4oukr2e570ll91
- OA Status
- bronze
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2403367199
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2403367199Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4149/gpb_2014042Digital Object Identifier
- Title
-
The interrelationship between cholinergic pathway in the magnocellular paraventricular nucleus and natriuresisWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2015Year of publication
- Publication date
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2015-01-01Full publication date if available
- Authors
-
Chunyan Wang, Min Wang, Hengai Zhang, Xijia Deng, Pengxu Wang, Huizheng Mao, Yuan Shao Lin, Chunling JiangList of authors in order
- Landing page
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https://doi.org/10.4149/gpb_2014042Publisher landing page
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https://www.elis.sk/download_file.php?product_id=4311&session_id=oebeqiu4l9tn4oukr2e570ll91Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://www.elis.sk/download_file.php?product_id=4311&session_id=oebeqiu4l9tn4oukr2e570ll91Direct OA link when available
- Concepts
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Natriuresis, Endocrinology, Internal medicine, Carbachol, Cholinergic, Chemistry, Magnocellular cell, Choline acetyltransferase, Stimulation, Kidney, Central nervous system, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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24Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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