The invasive proteome of glioblastoma revealed by laser-capture microdissection Article Swipe
Thomas Daubon
,
Joris Guyon
,
Anne‐Aurélie Raymond
,
Benjamin Dartigues
,
Justine Rudewicz
,
Zakaria Ezzoukhry
,
Jean‐William Dupuy
,
John Herbert
,
Frédéric Saltel
,
Rolf Bjerkvig
,
Macha Nikolski
,
Andréas Bikfalvi
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1093/noajnl/vdz029
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1093/noajnl/vdz029
Background Glioblastomas are heterogeneous tumors composed of a necrotic and tumor core and an invasive periphery. Methods Here, we performed a proteomics analysis of laser-capture micro-dissected glioblastoma core and invasive areas of patient-derived xenografts. Results Bioinformatics analysis identified enriched proteins in central and invasive tumor areas. Novel markers of invasion were identified, the genes proteolipid protein 1 (PLP1) and Dynamin-1 (DNM1), which were subsequently validated in tumors and by functional assays. Conclusions In summary, our results identify new networks and molecules that may play an important role in glioblastoma development and may constitute potential novel therapeutic targets.
Related Topics
Concepts
Laser capture microdissection
Glioblastoma
Proteome
Biology
Microdissection
Proteomics
Cancer research
Computational biology
Gene
Bioinformatics
Gene expression
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/noajnl/vdz029
- https://academic.oup.com/noa/article-pdf/1/1/vdz029/31152017/vdz029.pdf
- OA Status
- gold
- Cited By
- 14
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2975998169
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2975998169Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/noajnl/vdz029Digital Object Identifier
- Title
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The invasive proteome of glioblastoma revealed by laser-capture microdissectionWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-05-01Full publication date if available
- Authors
-
Thomas Daubon, Joris Guyon, Anne‐Aurélie Raymond, Benjamin Dartigues, Justine Rudewicz, Zakaria Ezzoukhry, Jean‐William Dupuy, John Herbert, Frédéric Saltel, Rolf Bjerkvig, Macha Nikolski, Andréas BikfalviList of authors in order
- Landing page
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https://doi.org/10.1093/noajnl/vdz029Publisher landing page
- PDF URL
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https://academic.oup.com/noa/article-pdf/1/1/vdz029/31152017/vdz029.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/noa/article-pdf/1/1/vdz029/31152017/vdz029.pdfDirect OA link when available
- Concepts
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Laser capture microdissection, Glioblastoma, Proteome, Biology, Microdissection, Proteomics, Cancer research, Computational biology, Gene, Bioinformatics, Gene expression, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2023: 4, 2022: 4, 2021: 3, 2020: 2Per-year citation counts (last 5 years)
- References (count)
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28Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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