The Janus Face of SPAG6 : Inducing EMT in Luminal Breast Cancer Cells Amidst Widespread Expression Loss in Breast Tumours
Article Swipe
Antonio Sechi
,
Jolein Mijnes
,
Sophia Villwock
,
Michael Rose
,
Florian Steib
,
Sarah Bringezu
,
Jonas Berger
,
Carmen Schalla
,
Sonja von Serényi
,
Jana Dietrich
,
Nadina Ortiz‐Brüchle
,
Lara R. Heij
,
Jan Bednarsch
,
Oleg Gluz
,
Ulrike Nitz
,
Nadia Harbeck
,
Monika Graeser
,
Christine zu Eulenburg
,
Mohammad Parsa Mohammadian
,
Katarzyna Jóźwiak
,
Hans‐Heinrich Kreipe
,
Matthias Christgen
,
Martin Radner
,
Danny Jonigk
,
Edgar Dahl
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/jcmm.70870
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/jcmm.70870
Understanding the role and molecular regulation of genes associated with tumour cell motility may be informative for future cancer therapy development. Sperm‐associated antigen 6 ( SPAG6 ) gene, encoding an evolutionarily highly conserved flagellar motility protein, is regulated by promoter hypermethylation in breast cancer. Our in silico analysis of healthy and breast cancer tissues from The Cancer Genome Atlas (TCGA) showed tumour‐specific SPAG6 promoter hypermethylation in all molecular subtypes. Immunohistochemistry on the independent WSG PlanB breast cancer cohort ( n = 2241) confirmed comprehensive down‐regulation of SPAG6 on the protein level. In vitro models demonstrated that SPAG6 overexpression in luminal cells exhibited strongly increased migration capacity ( p < 0.0001) and characteristics of epithelial‐mesenchymal transition (EMT) with actin and E‐cadherin displacement. We propose that SPAG6 may have an important role in triggering the EMT program in luminal breast cancer cells, driving tumour progression and metastasis. Trial Registration: ClinicalTrials.gov identifier: NCT01049425
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/jcmm.70870
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.70870
- OA Status
- gold
- References
- 70
- OpenAlex ID
- https://openalex.org/W4415003067
All OpenAlex metadata
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https://doi.org/10.1111/jcmm.70870Digital Object Identifier
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The Janus Face of
SPAG6 : InducingEMT in Luminal Breast Cancer Cells Amidst Widespread Expression Loss in Breast TumoursWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
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2025Year of publication
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2025-10-01Full publication date if available
- Authors
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Antonio Sechi, Jolein Mijnes, Sophia Villwock, Michael Rose, Florian Steib, Sarah Bringezu, Jonas Berger, Carmen Schalla, Sonja von Serényi, Jana Dietrich, Nadina Ortiz‐Brüchle, Lara R. Heij, Jan Bednarsch, Oleg Gluz, Ulrike Nitz, Nadia Harbeck, Monika Graeser, Christine zu Eulenburg, Mohammad Parsa Mohammadian, Katarzyna Jóźwiak, Hans‐Heinrich Kreipe, Matthias Christgen, Martin Radner, Danny Jonigk, Edgar DahlList of authors in order
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https://doi.org/10.1111/jcmm.70870Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.70870Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.70870Direct OA link when available
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0Total citation count in OpenAlex
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70Number of works referenced by this work
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