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Knockout mouse Biology Genetics Receptor

Christopher P. Austin , James F. Battey , Allan Bradley , Maja Bućan , Mario R. Capecchi , Francis S. Collins , W. F. Dove , Geoffrey M. Duyk , Susan M. Dymecki , Janan T. Eppig , Franziska B. Grieder , Nathaniel Heintz , Geoffrey G. Hicks , Thomas R. Insel , Alexandra L. Joyner , Beverly H. Koller , K.C. Kent Lloyd , Terry Magnuson , Mark W. Moore , András Nagy , Jonathan D. Pollock , Allen D. Roses , Arthur Sands , Brian Seed , William C. Skarnes , Jay Snoddy , Philippe Soriano , David J. Stewart , Francis Stewart , Bruce Stillman , Harold Varmus , Lyuba Varticovski , Inder M. Verma , Thomas Vogt , Harald von Melchner , Jan Witkowski , Richard P. Woychik , Wolfgang Wurst , George D. Yancopoulos , Stephen G. Young , Brian Zambrowicz , The Comprehensive Knockout Mouse Project Consortium ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.17615/4j1y-b823 · OA: W4299411525

Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.