The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer Article Swipe

View

J. Nathaniel Diehl , Jennifer E. Klomp , Kayla R. Snare , Priya S. Hibshman , Devon R. Blake , Zane D. Kaiser , Thomas S.K. Gilbert , Elisa Baldelli , Mariaelena Pierobon , Bjoern Papke , Runying Yang , Richard G. Hodge , Naim U. Rashid , Emanuel F. Petricoin , Laura E. Herring , Lee M. Graves , Adrienne D. Cox , Channing J. Der ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1016/j.jbc.2021.101335

Related Topics

Concepts

Kinome Wee1 KRAS Cancer research Kinase Downregulation and upregulation MAPK/ERK pathway Biology Cell biology Pancreatic cancer Cell cycle Cyclin-dependent kinase 1 Cancer Genetics Colorectal cancer Gene

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.jbc.2021.101335
OA Status: gold
Cited By: 27
References: 81
Related Works: 10
OpenAlex ID: https://openalex.org/W3205450755

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W3205450755

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1016/j.jbc.2021.101335

Digital Object Identifier
Title: The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2021

Year of publication
Publication date: 2021-10-22

Full publication date if available
Authors: J. Nathaniel Diehl, Jennifer E. Klomp, Kayla R. Snare, Priya S. Hibshman, Devon R. Blake, Zane D. Kaiser, Thomas S.K. Gilbert, Elisa Baldelli, Mariaelena Pierobon, Bjoern Papke, Runying Yang, Richard G. Hodge, Naim U. Rashid, Emanuel F. Petricoin, Laura E. Herring, Lee M. Graves, Adrienne D. Cox, Channing J. Der

List of authors in order
Landing page: https://doi.org/10.1016/j.jbc.2021.101335

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://doi.org/10.1016/j.jbc.2021.101335

Direct OA link when available
Concepts: Kinome, Wee1, KRAS, Cancer research, Kinase, Downregulation and upregulation, MAPK/ERK pathway, Biology, Cell biology, Pancreatic cancer, Cell cycle, Cyclin-dependent kinase 1, Cancer, Genetics, Colorectal cancer, Gene

Top concepts (fields/topics) attached by OpenAlex
Cited by: 27

Total citation count in OpenAlex
Citations by year (recent): 2025: 7, 2024: 6, 2023: 3, 2022: 9, 2021: 2

Per-year citation counts (last 5 years)
References (count): 81

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W3205450755
doi	https://doi.org/10.1016/j.jbc.2021.101335
ids.doi	https://doi.org/10.1016/j.jbc.2021.101335
ids.mag	3205450755
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/34688654
ids.openalex	https://openalex.org/W3205450755
fwci	2.09662987
mesh[0].qualifier_ui	Q000188
mesh[0].descriptor_ui	D021441
mesh[0].is_major_topic	True
mesh[0].qualifier_name	drug therapy
mesh[0].descriptor_name	Carcinoma, Pancreatic Ductal
mesh[1].qualifier_ui	Q000201
mesh[1].descriptor_ui	D021441
mesh[1].is_major_topic	True
mesh[1].qualifier_name	enzymology
mesh[1].descriptor_name	Carcinoma, Pancreatic Ductal
mesh[2].qualifier_ui	Q000235
mesh[2].descriptor_ui	D021441
mesh[2].is_major_topic	True
mesh[2].qualifier_name	genetics
mesh[2].descriptor_name	Carcinoma, Pancreatic Ductal
mesh[3].qualifier_ui	Q000235
mesh[3].descriptor_ui	D018797
mesh[3].is_major_topic	False
mesh[3].qualifier_name	genetics
mesh[3].descriptor_name	Cell Cycle Proteins
mesh[4].qualifier_ui	Q000378
mesh[4].descriptor_ui	D018797
mesh[4].is_major_topic	False
mesh[4].qualifier_name	metabolism
mesh[4].descriptor_name	Cell Cycle Proteins
mesh[5].qualifier_ui
mesh[5].descriptor_ui	D045744
mesh[5].is_major_topic	False
mesh[5].qualifier_name
mesh[5].descriptor_name	Cell Line, Tumor
mesh[6].qualifier_ui
mesh[6].descriptor_ui	D006801
mesh[6].is_major_topic	False
mesh[6].qualifier_name
mesh[6].descriptor_name	Humans
mesh[7].qualifier_ui	Q000187
mesh[7].descriptor_ui	D020935
mesh[7].is_major_topic	False
mesh[7].qualifier_name	drug effects
mesh[7].descriptor_name	MAP Kinase Signaling System
mesh[8].qualifier_ui
mesh[8].descriptor_ui	D009154
mesh[8].is_major_topic	True
mesh[8].qualifier_name
mesh[8].descriptor_name	Mutation
mesh[9].qualifier_ui	Q000188
mesh[9].descriptor_ui	D010190
mesh[9].is_major_topic	True
mesh[9].qualifier_name	drug therapy
mesh[9].descriptor_name	Pancreatic Neoplasms
mesh[10].qualifier_ui	Q000201
mesh[10].descriptor_ui	D010190
mesh[10].is_major_topic	True
mesh[10].qualifier_name	enzymology
mesh[10].descriptor_name	Pancreatic Neoplasms
mesh[11].qualifier_ui	Q000235
mesh[11].descriptor_ui	D010190
mesh[11].is_major_topic	True
mesh[11].qualifier_name	genetics
mesh[11].descriptor_name	Pancreatic Neoplasms
mesh[12].qualifier_ui	Q000235
mesh[12].descriptor_ui	D011505
mesh[12].is_major_topic	False
mesh[12].qualifier_name	genetics
mesh[12].descriptor_name	Protein-Tyrosine Kinases
mesh[13].qualifier_ui	Q000378
mesh[13].descriptor_ui	D011505
mesh[13].is_major_topic	False
mesh[13].qualifier_name	metabolism
mesh[13].descriptor_name	Protein-Tyrosine Kinases
mesh[14].qualifier_ui	Q000037
mesh[14].descriptor_ui	D016283
mesh[14].is_major_topic	True
mesh[14].qualifier_name	antagonists & inhibitors
mesh[14].descriptor_name	Proto-Oncogene Proteins p21(ras)
mesh[15].qualifier_ui	Q000235
mesh[15].descriptor_ui	D016283
mesh[15].is_major_topic	True
mesh[15].qualifier_name	genetics
mesh[15].descriptor_name	Proto-Oncogene Proteins p21(ras)
mesh[16].qualifier_ui	Q000378
mesh[16].descriptor_ui	D016283
mesh[16].is_major_topic	True
mesh[16].qualifier_name	metabolism
mesh[16].descriptor_name	Proto-Oncogene Proteins p21(ras)
mesh[17].qualifier_ui	Q000188
mesh[17].descriptor_ui	D021441
mesh[17].is_major_topic	True
mesh[17].qualifier_name	drug therapy
mesh[17].descriptor_name	Carcinoma, Pancreatic Ductal
mesh[18].qualifier_ui	Q000201
mesh[18].descriptor_ui	D021441
mesh[18].is_major_topic	True
mesh[18].qualifier_name	enzymology
mesh[18].descriptor_name	Carcinoma, Pancreatic Ductal
mesh[19].qualifier_ui	Q000235
mesh[19].descriptor_ui	D021441
mesh[19].is_major_topic	True
mesh[19].qualifier_name	genetics
mesh[19].descriptor_name	Carcinoma, Pancreatic Ductal
mesh[20].qualifier_ui	Q000235
mesh[20].descriptor_ui	D018797
mesh[20].is_major_topic	False
mesh[20].qualifier_name	genetics
mesh[20].descriptor_name	Cell Cycle Proteins
mesh[21].qualifier_ui	Q000378
mesh[21].descriptor_ui	D018797
mesh[21].is_major_topic	False
mesh[21].qualifier_name	metabolism
mesh[21].descriptor_name	Cell Cycle Proteins
mesh[22].qualifier_ui
mesh[22].descriptor_ui	D045744
mesh[22].is_major_topic	False
mesh[22].qualifier_name
mesh[22].descriptor_name	Cell Line, Tumor
mesh[23].qualifier_ui
mesh[23].descriptor_ui	D006801
mesh[23].is_major_topic	False
mesh[23].qualifier_name
mesh[23].descriptor_name	Humans
mesh[24].qualifier_ui	Q000187
mesh[24].descriptor_ui	D020935
mesh[24].is_major_topic	False
mesh[24].qualifier_name	drug effects
mesh[24].descriptor_name	MAP Kinase Signaling System
mesh[25].qualifier_ui
mesh[25].descriptor_ui	D009154
mesh[25].is_major_topic	True
mesh[25].qualifier_name
mesh[25].descriptor_name	Mutation
mesh[26].qualifier_ui	Q000188
mesh[26].descriptor_ui	D010190
mesh[26].is_major_topic	True
mesh[26].qualifier_name	drug therapy
mesh[26].descriptor_name	Pancreatic Neoplasms
mesh[27].qualifier_ui	Q000201
mesh[27].descriptor_ui	D010190
mesh[27].is_major_topic	True
mesh[27].qualifier_name	enzymology
mesh[27].descriptor_name	Pancreatic Neoplasms
mesh[28].qualifier_ui	Q000235
mesh[28].descriptor_ui	D010190
mesh[28].is_major_topic	True
mesh[28].qualifier_name	genetics
mesh[28].descriptor_name	Pancreatic Neoplasms
mesh[29].qualifier_ui	Q000235
mesh[29].descriptor_ui	D011505
mesh[29].is_major_topic	False
mesh[29].qualifier_name	genetics
mesh[29].descriptor_name	Protein-Tyrosine Kinases
mesh[30].qualifier_ui	Q000378
mesh[30].descriptor_ui	D011505
mesh[30].is_major_topic	False
mesh[30].qualifier_name	metabolism
mesh[30].descriptor_name	Protein-Tyrosine Kinases
mesh[31].qualifier_ui	Q000037
mesh[31].descriptor_ui	D016283
mesh[31].is_major_topic	True
mesh[31].qualifier_name	antagonists & inhibitors
mesh[31].descriptor_name	Proto-Oncogene Proteins p21(ras)
mesh[32].qualifier_ui	Q000235
mesh[32].descriptor_ui	D016283
mesh[32].is_major_topic	True
mesh[32].qualifier_name	genetics
mesh[32].descriptor_name	Proto-Oncogene Proteins p21(ras)
mesh[33].qualifier_ui	Q000378
mesh[33].descriptor_ui	D016283
mesh[33].is_major_topic	True
mesh[33].qualifier_name	metabolism
mesh[33].descriptor_name	Proto-Oncogene Proteins p21(ras)
type	article
title	The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer
biblio.issue	5
biblio.volume	297
biblio.last_page	101335
biblio.first_page	101335
topics[0].id	https://openalex.org/T10231
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9994999766349792
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2730
topics[0].subfield.display_name	Oncology
topics[0].display_name	Pancreatic and Hepatic Oncology Research
topics[1].id	https://openalex.org/T10492
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.9927999973297119
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1307
topics[1].subfield.display_name	Cell Biology
topics[1].display_name	Microtubule and mitosis dynamics
topics[2].id	https://openalex.org/T13779
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9836999773979187
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2734
topics[2].subfield.display_name	Pathology and Forensic Medicine
topics[2].display_name	Cancer Mechanisms and Therapy
is_xpac	False
apc_list.value	2500
apc_list.currency	USD
apc_list.value_usd	2500
apc_paid.value	2500
apc_paid.currency	USD
apc_paid.value_usd	2500
concepts[0].id	https://openalex.org/C54174078
concepts[0].level	3
concepts[0].score	0.9532753229141235
concepts[0].wikidata	https://www.wikidata.org/wiki/Q3197188
concepts[0].display_name	Kinome
concepts[1].id	https://openalex.org/C2781252693
concepts[1].level	5
concepts[1].score	0.909965991973877
concepts[1].wikidata	https://www.wikidata.org/wiki/Q7979264
concepts[1].display_name	Wee1
concepts[2].id	https://openalex.org/C2781187634
concepts[2].level	4
concepts[2].score	0.9084987044334412
concepts[2].wikidata	https://www.wikidata.org/wiki/Q20969980
concepts[2].display_name	KRAS
concepts[3].id	https://openalex.org/C502942594
concepts[3].level	1
concepts[3].score	0.66123366355896
concepts[3].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[3].display_name	Cancer research
concepts[4].id	https://openalex.org/C184235292
concepts[4].level	2
concepts[4].score	0.5849344730377197
concepts[4].wikidata	https://www.wikidata.org/wiki/Q421851
concepts[4].display_name	Kinase
concepts[5].id	https://openalex.org/C127561419
concepts[5].level	3
concepts[5].score	0.5814274549484253
concepts[5].wikidata	https://www.wikidata.org/wiki/Q224527
concepts[5].display_name	Downregulation and upregulation
concepts[6].id	https://openalex.org/C57074206
concepts[6].level	3
concepts[6].score	0.5583065152168274
concepts[6].wikidata	https://www.wikidata.org/wiki/Q14197552
concepts[6].display_name	MAPK/ERK pathway
concepts[7].id	https://openalex.org/C86803240
concepts[7].level	0
concepts[7].score	0.5172544121742249
concepts[7].wikidata	https://www.wikidata.org/wiki/Q420
concepts[7].display_name	Biology
concepts[8].id	https://openalex.org/C95444343
concepts[8].level	1
concepts[8].score	0.41591671109199524
concepts[8].wikidata	https://www.wikidata.org/wiki/Q7141
concepts[8].display_name	Cell biology
concepts[9].id	https://openalex.org/C2780210213
concepts[9].level	3
concepts[9].score	0.4137396812438965
concepts[9].wikidata	https://www.wikidata.org/wiki/Q212961
concepts[9].display_name	Pancreatic cancer
concepts[10].id	https://openalex.org/C29537977
concepts[10].level	3
concepts[10].score	0.4008295238018036
concepts[10].wikidata	https://www.wikidata.org/wiki/Q188941
concepts[10].display_name	Cell cycle
concepts[11].id	https://openalex.org/C120504264
concepts[11].level	4
concepts[11].score	0.3322775959968567
concepts[11].wikidata	https://www.wikidata.org/wiki/Q1147372
concepts[11].display_name	Cyclin-dependent kinase 1
concepts[12].id	https://openalex.org/C121608353
concepts[12].level	2
concepts[12].score	0.30601462721824646
concepts[12].wikidata	https://www.wikidata.org/wiki/Q12078
concepts[12].display_name	Cancer
concepts[13].id	https://openalex.org/C54355233
concepts[13].level	1
concepts[13].score	0.0861196517944336
concepts[13].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[13].display_name	Genetics
concepts[14].id	https://openalex.org/C526805850
concepts[14].level	3
concepts[14].score	0.0
concepts[14].wikidata	https://www.wikidata.org/wiki/Q188874
concepts[14].display_name	Colorectal cancer
concepts[15].id	https://openalex.org/C104317684
concepts[15].level	2
concepts[15].score	0.0
concepts[15].wikidata	https://www.wikidata.org/wiki/Q7187
concepts[15].display_name	Gene
keywords[0].id	https://openalex.org/keywords/kinome
keywords[0].score	0.9532753229141235
keywords[0].display_name	Kinome
keywords[1].id	https://openalex.org/keywords/wee1
keywords[1].score	0.909965991973877
keywords[1].display_name	Wee1
keywords[2].id	https://openalex.org/keywords/kras
keywords[2].score	0.9084987044334412
keywords[2].display_name	KRAS
keywords[3].id	https://openalex.org/keywords/cancer-research
keywords[3].score	0.66123366355896
keywords[3].display_name	Cancer research
keywords[4].id	https://openalex.org/keywords/kinase
keywords[4].score	0.5849344730377197
keywords[4].display_name	Kinase
keywords[5].id	https://openalex.org/keywords/downregulation-and-upregulation
keywords[5].score	0.5814274549484253
keywords[5].display_name	Downregulation and upregulation
keywords[6].id	https://openalex.org/keywords/mapk/erk-pathway
keywords[6].score	0.5583065152168274
keywords[6].display_name	MAPK/ERK pathway
keywords[7].id	https://openalex.org/keywords/biology
keywords[7].score	0.5172544121742249
keywords[7].display_name	Biology
keywords[8].id	https://openalex.org/keywords/cell-biology
keywords[8].score	0.41591671109199524
keywords[8].display_name	Cell biology
keywords[9].id	https://openalex.org/keywords/pancreatic-cancer
keywords[9].score	0.4137396812438965
keywords[9].display_name	Pancreatic cancer
keywords[10].id	https://openalex.org/keywords/cell-cycle
keywords[10].score	0.4008295238018036
keywords[10].display_name	Cell cycle
keywords[11].id	https://openalex.org/keywords/cyclin-dependent-kinase-1
keywords[11].score	0.3322775959968567
keywords[11].display_name	Cyclin-dependent kinase 1
keywords[12].id	https://openalex.org/keywords/cancer
keywords[12].score	0.30601462721824646
keywords[12].display_name	Cancer
keywords[13].id	https://openalex.org/keywords/genetics
keywords[13].score	0.0861196517944336
keywords[13].display_name	Genetics
language	en
locations[0].id	doi:10.1016/j.jbc.2021.101335
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S140251998
locations[0].source.issn	0021-9258, 1067-8816, 1083-351X
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	0021-9258
locations[0].source.is_core	True
locations[0].source.is_in_doaj	True
locations[0].source.display_name	Journal of Biological Chemistry
locations[0].source.host_organization	https://openalex.org/P4310320990
locations[0].source.host_organization_name	Elsevier BV
locations[0].source.host_organization_lineage	https://openalex.org/P4310320990
locations[0].source.host_organization_lineage_names	Elsevier BV
locations[0].license
locations[0].pdf_url
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Journal of Biological Chemistry
locations[0].landing_page_url	https://doi.org/10.1016/j.jbc.2021.101335
locations[1].id	pmid:34688654
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	The Journal of biological chemistry
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/34688654
locations[2].id	pmh:oai:pubmedcentral.nih.gov:8591367
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S2764455111
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	PubMed Central
locations[2].source.host_organization	https://openalex.org/I1299303238
locations[2].source.host_organization_name	National Institutes of Health
locations[2].source.host_organization_lineage	https://openalex.org/I1299303238
locations[2].license	other-oa
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	Text
locations[2].license_id	https://openalex.org/licenses/other-oa
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name	J Biol Chem
locations[2].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/8591367
indexed_in	crossref, doaj, pubmed
authorships[0].author.id	https://openalex.org/A5081651746
authorships[0].author.orcid	https://orcid.org/0000-0002-7309-0903
authorships[0].author.display_name	J. Nathaniel Diehl
authorships[0].countries	US
authorships[0].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[0].affiliations[0].raw_affiliation_string	Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[0].institutions[0].id	https://openalex.org/I114027177
authorships[0].institutions[0].ror	https://ror.org/0130frc33
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I114027177
authorships[0].institutions[0].country_code	US
authorships[0].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[0].author_position	first
authorships[0].raw_author_name	J. Nathaniel Diehl
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[1].author.id	https://openalex.org/A5002303136
authorships[1].author.orcid	https://orcid.org/0000-0003-1781-648X
authorships[1].author.display_name	Jennifer E. Klomp
authorships[1].countries	US
authorships[1].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[1].affiliations[0].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[1].institutions[0].id	https://openalex.org/I114027177
authorships[1].institutions[0].ror	https://ror.org/0130frc33
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I114027177
authorships[1].institutions[0].country_code	US
authorships[1].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[1].author_position	middle
authorships[1].raw_author_name	Jennifer E. Klomp
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[2].author.id	https://openalex.org/A5041722180
authorships[2].author.orcid
authorships[2].author.display_name	Kayla R. Snare
authorships[2].countries	US
authorships[2].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[2].affiliations[0].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[2].institutions[0].id	https://openalex.org/I114027177
authorships[2].institutions[0].ror	https://ror.org/0130frc33
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I114027177
authorships[2].institutions[0].country_code	US
authorships[2].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[2].author_position	middle
authorships[2].raw_author_name	Kayla R. Snare
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[3].author.id	https://openalex.org/A5051154001
authorships[3].author.orcid
authorships[3].author.display_name	Priya S. Hibshman
authorships[3].countries	US
authorships[3].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[3].affiliations[0].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[3].institutions[0].id	https://openalex.org/I114027177
authorships[3].institutions[0].ror	https://ror.org/0130frc33
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I114027177
authorships[3].institutions[0].country_code	US
authorships[3].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[3].author_position	middle
authorships[3].raw_author_name	Priya S. Hibshman
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[4].author.id	https://openalex.org/A5083715247
authorships[4].author.orcid	https://orcid.org/0000-0002-8592-2332
authorships[4].author.display_name	Devon R. Blake
authorships[4].countries	US
authorships[4].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[4].affiliations[0].raw_affiliation_string	Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[4].institutions[0].id	https://openalex.org/I114027177
authorships[4].institutions[0].ror	https://ror.org/0130frc33
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I114027177
authorships[4].institutions[0].country_code	US
authorships[4].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[4].author_position	middle
authorships[4].raw_author_name	Devon R. Blake
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[5].author.id	https://openalex.org/A5055963339
authorships[5].author.orcid	https://orcid.org/0009-0001-9260-9395
authorships[5].author.display_name	Zane D. Kaiser
authorships[5].countries	US
authorships[5].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[5].affiliations[0].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[5].institutions[0].id	https://openalex.org/I114027177
authorships[5].institutions[0].ror	https://ror.org/0130frc33
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I114027177
authorships[5].institutions[0].country_code	US
authorships[5].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[5].author_position	middle
authorships[5].raw_author_name	Zane D. Kaiser
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[6].author.id	https://openalex.org/A5042488037
authorships[6].author.orcid	https://orcid.org/0000-0002-6833-6788
authorships[6].author.display_name	Thomas S.K. Gilbert
authorships[6].countries	US
authorships[6].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[6].affiliations[0].raw_affiliation_string	UNC Michael Hooker Proteomics Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[6].affiliations[1].institution_ids	https://openalex.org/I114027177
authorships[6].affiliations[1].raw_affiliation_string	Cell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[6].institutions[0].id	https://openalex.org/I114027177
authorships[6].institutions[0].ror	https://ror.org/0130frc33
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I114027177
authorships[6].institutions[0].country_code	US
authorships[6].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[6].author_position	middle
authorships[6].raw_author_name	Thomas S.K. Gilbert
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Cell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, UNC Michael Hooker Proteomics Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[7].author.id	https://openalex.org/A5025478813
authorships[7].author.orcid	https://orcid.org/0000-0002-6288-4599
authorships[7].author.display_name	Elisa Baldelli
authorships[7].countries	US
authorships[7].affiliations[0].institution_ids	https://openalex.org/I162714631
authorships[7].affiliations[0].raw_affiliation_string	Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, USA
authorships[7].institutions[0].id	https://openalex.org/I162714631
authorships[7].institutions[0].ror	https://ror.org/02jqj7156
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I162714631
authorships[7].institutions[0].country_code	US
authorships[7].institutions[0].display_name	George Mason University
authorships[7].author_position	middle
authorships[7].raw_author_name	Elisa Baldelli
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, USA
authorships[8].author.id	https://openalex.org/A5073337554
authorships[8].author.orcid	https://orcid.org/0000-0003-2084-1029
authorships[8].author.display_name	Mariaelena Pierobon
authorships[8].countries	US
authorships[8].affiliations[0].institution_ids	https://openalex.org/I162714631
authorships[8].affiliations[0].raw_affiliation_string	Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, USA
authorships[8].institutions[0].id	https://openalex.org/I162714631
authorships[8].institutions[0].ror	https://ror.org/02jqj7156
authorships[8].institutions[0].type	education
authorships[8].institutions[0].lineage	https://openalex.org/I162714631
authorships[8].institutions[0].country_code	US
authorships[8].institutions[0].display_name	George Mason University
authorships[8].author_position	middle
authorships[8].raw_author_name	Mariaelena Pierobon
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, USA
authorships[9].author.id	https://openalex.org/A5015413269
authorships[9].author.orcid	https://orcid.org/0000-0001-8156-7508
authorships[9].author.display_name	Bjoern Papke
authorships[9].countries	US
authorships[9].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[9].affiliations[0].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[9].institutions[0].id	https://openalex.org/I114027177
authorships[9].institutions[0].ror	https://ror.org/0130frc33
authorships[9].institutions[0].type	education
authorships[9].institutions[0].lineage	https://openalex.org/I114027177
authorships[9].institutions[0].country_code	US
authorships[9].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[9].author_position	middle
authorships[9].raw_author_name	Björn Papke
authorships[9].is_corresponding	False
authorships[9].raw_affiliation_strings	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[10].author.id	https://openalex.org/A5087221132
authorships[10].author.orcid	https://orcid.org/0000-0002-1048-9298
authorships[10].author.display_name	Runying Yang
authorships[10].countries	US
authorships[10].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[10].affiliations[0].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[10].institutions[0].id	https://openalex.org/I114027177
authorships[10].institutions[0].ror	https://ror.org/0130frc33
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I114027177
authorships[10].institutions[0].country_code	US
authorships[10].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[10].author_position	middle
authorships[10].raw_author_name	Runying Yang
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[11].author.id	https://openalex.org/A5029358583
authorships[11].author.orcid	https://orcid.org/0000-0002-1920-1385
authorships[11].author.display_name	Richard G. Hodge
authorships[11].countries	US
authorships[11].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[11].affiliations[0].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[11].institutions[0].id	https://openalex.org/I114027177
authorships[11].institutions[0].ror	https://ror.org/0130frc33
authorships[11].institutions[0].type	education
authorships[11].institutions[0].lineage	https://openalex.org/I114027177
authorships[11].institutions[0].country_code	US
authorships[11].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[11].author_position	middle
authorships[11].raw_author_name	Richard G. Hodge
authorships[11].is_corresponding	False
authorships[11].raw_affiliation_strings	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[12].author.id	https://openalex.org/A5065665275
authorships[12].author.orcid	https://orcid.org/0000-0002-7274-8259
authorships[12].author.display_name	Naim U. Rashid
authorships[12].countries	US
authorships[12].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[12].affiliations[0].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[12].affiliations[1].institution_ids	https://openalex.org/I114027177
authorships[12].affiliations[1].raw_affiliation_string	Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[12].institutions[0].id	https://openalex.org/I114027177
authorships[12].institutions[0].ror	https://ror.org/0130frc33
authorships[12].institutions[0].type	education
authorships[12].institutions[0].lineage	https://openalex.org/I114027177
authorships[12].institutions[0].country_code	US
authorships[12].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[12].author_position	middle
authorships[12].raw_author_name	Naim U. Rashid
authorships[12].is_corresponding	False
authorships[12].raw_affiliation_strings	Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[13].author.id	https://openalex.org/A5023762376
authorships[13].author.orcid	https://orcid.org/0000-0001-9146-5572
authorships[13].author.display_name	Emanuel F. Petricoin
authorships[13].countries	US
authorships[13].affiliations[0].institution_ids	https://openalex.org/I162714631
authorships[13].affiliations[0].raw_affiliation_string	Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, USA
authorships[13].institutions[0].id	https://openalex.org/I162714631
authorships[13].institutions[0].ror	https://ror.org/02jqj7156
authorships[13].institutions[0].type	education
authorships[13].institutions[0].lineage	https://openalex.org/I162714631
authorships[13].institutions[0].country_code	US
authorships[13].institutions[0].display_name	George Mason University
authorships[13].author_position	middle
authorships[13].raw_author_name	Emanuel F. Petricoin
authorships[13].is_corresponding	False
authorships[13].raw_affiliation_strings	Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia, USA
authorships[14].author.id	https://openalex.org/A5053713564
authorships[14].author.orcid	https://orcid.org/0000-0003-4496-7312
authorships[14].author.display_name	Laura E. Herring
authorships[14].countries	US
authorships[14].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[14].affiliations[0].raw_affiliation_string	Cell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[14].affiliations[1].institution_ids	https://openalex.org/I114027177
authorships[14].affiliations[1].raw_affiliation_string	UNC Michael Hooker Proteomics Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[14].institutions[0].id	https://openalex.org/I114027177
authorships[14].institutions[0].ror	https://ror.org/0130frc33
authorships[14].institutions[0].type	education
authorships[14].institutions[0].lineage	https://openalex.org/I114027177
authorships[14].institutions[0].country_code	US
authorships[14].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[14].author_position	middle
authorships[14].raw_author_name	Laura E. Herring
authorships[14].is_corresponding	False
authorships[14].raw_affiliation_strings	Cell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, UNC Michael Hooker Proteomics Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[15].author.id	https://openalex.org/A5082891287
authorships[15].author.orcid	https://orcid.org/0000-0002-4736-9855
authorships[15].author.display_name	Lee M. Graves
authorships[15].countries	US
authorships[15].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[15].affiliations[0].raw_affiliation_string	UNC Michael Hooker Proteomics Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[15].affiliations[1].institution_ids	https://openalex.org/I114027177
authorships[15].affiliations[1].raw_affiliation_string	Cell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[15].affiliations[2].institution_ids	https://openalex.org/I114027177
authorships[15].affiliations[2].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[15].institutions[0].id	https://openalex.org/I114027177
authorships[15].institutions[0].ror	https://ror.org/0130frc33
authorships[15].institutions[0].type	education
authorships[15].institutions[0].lineage	https://openalex.org/I114027177
authorships[15].institutions[0].country_code	US
authorships[15].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[15].author_position	middle
authorships[15].raw_author_name	Lee M. Graves
authorships[15].is_corresponding	False
authorships[15].raw_affiliation_strings	Cell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, UNC Michael Hooker Proteomics Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[16].author.id	https://openalex.org/A5005839868
authorships[16].author.orcid	https://orcid.org/0000-0002-4901-2454
authorships[16].author.display_name	Adrienne D. Cox
authorships[16].countries	US
authorships[16].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[16].affiliations[0].raw_affiliation_string	Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[16].affiliations[1].institution_ids	https://openalex.org/I114027177
authorships[16].affiliations[1].raw_affiliation_string	Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[16].affiliations[2].institution_ids	https://openalex.org/I114027177
authorships[16].affiliations[2].raw_affiliation_string	Cell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[16].affiliations[3].institution_ids	https://openalex.org/I114027177
authorships[16].affiliations[3].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[16].institutions[0].id	https://openalex.org/I114027177
authorships[16].institutions[0].ror	https://ror.org/0130frc33
authorships[16].institutions[0].type	education
authorships[16].institutions[0].lineage	https://openalex.org/I114027177
authorships[16].institutions[0].country_code	US
authorships[16].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[16].author_position	middle
authorships[16].raw_author_name	Adrienne D. Cox
authorships[16].is_corresponding	False
authorships[16].raw_affiliation_strings	Cell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[17].author.id	https://openalex.org/A5064063895
authorships[17].author.orcid	https://orcid.org/0000-0002-7751-2747
authorships[17].author.display_name	Channing J. Der
authorships[17].countries	US
authorships[17].affiliations[0].institution_ids	https://openalex.org/I114027177
authorships[17].affiliations[0].raw_affiliation_string	Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[17].affiliations[1].institution_ids	https://openalex.org/I114027177
authorships[17].affiliations[1].raw_affiliation_string	Cell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[17].affiliations[2].institution_ids	https://openalex.org/I114027177
authorships[17].affiliations[2].raw_affiliation_string	Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[17].affiliations[3].institution_ids	https://openalex.org/I114027177
authorships[17].affiliations[3].raw_affiliation_string	Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
authorships[17].institutions[0].id	https://openalex.org/I114027177
authorships[17].institutions[0].ror	https://ror.org/0130frc33
authorships[17].institutions[0].type	education
authorships[17].institutions[0].lineage	https://openalex.org/I114027177
authorships[17].institutions[0].country_code	US
authorships[17].institutions[0].display_name	University of North Carolina at Chapel Hill
authorships[17].author_position	last
authorships[17].raw_author_name	Channing J. Der
authorships[17].is_corresponding	True
authorships[17].raw_affiliation_strings	Cell Biology and Physiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1016/j.jbc.2021.101335
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10231
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9994999766349792
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2730
primary_topic.subfield.display_name	Oncology
primary_topic.display_name	Pancreatic and Hepatic Oncology Research
related_works	https://openalex.org/W3174277730, https://openalex.org/W2035175399, https://openalex.org/W3205450755, https://openalex.org/W3159637810, https://openalex.org/W2744376322, https://openalex.org/W2563237728, https://openalex.org/W1905156128, https://openalex.org/W2149794096, https://openalex.org/W2091549602, https://openalex.org/W147529276
cited_by_count	27
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	7
counts_by_year[1].year	2024
counts_by_year[1].cited_by_count	6
counts_by_year[2].year	2023
counts_by_year[2].cited_by_count	3
counts_by_year[3].year	2022
counts_by_year[3].cited_by_count	9
counts_by_year[4].year	2021
counts_by_year[4].cited_by_count	2
locations_count	3
best_oa_location.id	doi:10.1016/j.jbc.2021.101335
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S140251998
best_oa_location.source.issn	0021-9258, 1067-8816, 1083-351X
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	0021-9258
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	True
best_oa_location.source.display_name	Journal of Biological Chemistry
best_oa_location.source.host_organization	https://openalex.org/P4310320990
best_oa_location.source.host_organization_name	Elsevier BV
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310320990
best_oa_location.source.host_organization_lineage_names	Elsevier BV
best_oa_location.license
best_oa_location.pdf_url
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Journal of Biological Chemistry
best_oa_location.landing_page_url	https://doi.org/10.1016/j.jbc.2021.101335
primary_location.id	doi:10.1016/j.jbc.2021.101335
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S140251998
primary_location.source.issn	0021-9258, 1067-8816, 1083-351X
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	0021-9258
primary_location.source.is_core	True
primary_location.source.is_in_doaj	True
primary_location.source.display_name	Journal of Biological Chemistry
primary_location.source.host_organization	https://openalex.org/P4310320990
primary_location.source.host_organization_name	Elsevier BV
primary_location.source.host_organization_lineage	https://openalex.org/P4310320990
primary_location.source.host_organization_lineage_names	Elsevier BV
primary_location.license
primary_location.pdf_url
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Journal of Biological Chemistry
primary_location.landing_page_url	https://doi.org/10.1016/j.jbc.2021.101335
publication_date	2021-10-22
publication_year	2021
referenced_works	https://openalex.org/W3119005666, https://openalex.org/W2748710555, https://openalex.org/W3008609311, https://openalex.org/W3013112801, https://openalex.org/W2982602983, https://openalex.org/W2982321167, https://openalex.org/W2771729549, https://openalex.org/W2597182072, https://openalex.org/W2097709883, https://openalex.org/W2728981453, https://openalex.org/W2107495112, https://openalex.org/W2047401805, https://openalex.org/W2211890826, https://openalex.org/W2100614336, https://openalex.org/W2586327969, https://openalex.org/W2165067070, https://openalex.org/W2155696445, https://openalex.org/W2785254688, https://openalex.org/W2111645707, https://openalex.org/W2903228835, https://openalex.org/W2532506230, https://openalex.org/W2465367340, https://openalex.org/W2099516272, https://openalex.org/W1947532554, https://openalex.org/W2947368578, https://openalex.org/W2027711745, https://openalex.org/W3035118524, https://openalex.org/W6600427277, https://openalex.org/W2165575701, https://openalex.org/W2799455659, https://openalex.org/W6757476301, https://openalex.org/W2806304252, https://openalex.org/W2138155367, https://openalex.org/W2161884651, https://openalex.org/W1987313243, https://openalex.org/W2067826589, https://openalex.org/W2399220382, https://openalex.org/W2062983115, https://openalex.org/W2116386978, https://openalex.org/W2888987731, https://openalex.org/W2133591242, https://openalex.org/W1653306654, https://openalex.org/W1993034428, https://openalex.org/W2936120062, https://openalex.org/W2184894459, https://openalex.org/W3017755151, https://openalex.org/W2751614779, https://openalex.org/W2009459159, https://openalex.org/W2096979580, https://openalex.org/W6754741110, https://openalex.org/W4231423004, https://openalex.org/W2039525991, https://openalex.org/W2968502728, https://openalex.org/W2278792103, https://openalex.org/W1989832696, https://openalex.org/W2580129211, https://openalex.org/W2010916968, https://openalex.org/W2807088563, https://openalex.org/W3014191583, https://openalex.org/W2765585947, https://openalex.org/W2949677600, https://openalex.org/W2596919450, https://openalex.org/W2320687212, https://openalex.org/W3042711809, https://openalex.org/W3104378422, https://openalex.org/W2766798501, https://openalex.org/W2604617217, https://openalex.org/W3092288940, https://openalex.org/W2060252361, https://openalex.org/W2749893104, https://openalex.org/W2607728961, https://openalex.org/W4232218865, https://openalex.org/W2165207436, https://openalex.org/W1578932543, https://openalex.org/W2103017472, https://openalex.org/W3112600195, https://openalex.org/W2415215726, https://openalex.org/W2904612308, https://openalex.org/W2894279443, https://openalex.org/W2994953911, https://openalex.org/W10562162
referenced_works_count	81
abstract_inverted_index
cited_by_percentile_year.max	99
cited_by_percentile_year.min	93
corresponding_author_ids	https://openalex.org/A5064063895
countries_distinct_count	1
institutions_distinct_count	18
corresponding_institution_ids	https://openalex.org/I114027177
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.7900000214576721
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.88682975
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	True