The long-term stability of solid-state oral pharmaceuticals exposed to simulated intravehicular space radiation Article Swipe
Ianik Plante
,
Vernie Daniels
,
Millennia Young
,
Ramona Gaza
,
Honglu Wu
,
John F. Reichard
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41526-025-00469-w
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41526-025-00469-w
Pharmaceutical products brought for space missions must remain effective and safe throughout the mission. Previous NASA experiments suggest that radiation exposure could threaten drug stability during long-duration space missions. The Exploration Medical Capability (ExMC) Element has evaluated this possibility by exposing four medications to simulated Galactic Cosmic Radiation (GCRSim) at the NASA Space Radiation Laboratory followed by a three-year storage period. The solid oral drug products Acetaminophen, Amoxicillin, Ibuprofen, and Promethazine were used. Identical lots of each medication were assigned to four experimental groups: the non-irradiated Johnson Space Center control group, the non-irradiated traveling control group, the irradiation group I (GRSim, 0.5 Gy), and the irradiation group II (GCRSim, 1.0 Gy). Drug products were assessed for active pharmaceutical ingredient, degradation impurities, and dissolution 2, 18, and 34 months after irradiation. All samples show comparable degradation, revealing that GCR exposure does not facilitate the degradation of the drugs.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41526-025-00469-w
- https://www.nature.com/articles/s41526-025-00469-w.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410454975
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410454975Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41526-025-00469-wDigital Object Identifier
- Title
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The long-term stability of solid-state oral pharmaceuticals exposed to simulated intravehicular space radiationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-05-17Full publication date if available
- Authors
-
Ianik Plante, Vernie Daniels, Millennia Young, Ramona Gaza, Honglu Wu, John F. ReichardList of authors in order
- Landing page
-
https://doi.org/10.1038/s41526-025-00469-wPublisher landing page
- PDF URL
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https://www.nature.com/articles/s41526-025-00469-w.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41526-025-00469-w.pdfDirect OA link when available
- Concepts
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Term (time), Radiation, Solid-state, Stability (learning theory), Environmental science, Space (punctuation), Physics, Computer science, Optics, Engineering physics, Machine learning, Quantum mechanics, Operating systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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42Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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