The Management of Adrenocortical Carcinomas in The Era of Precision Medicine Article Swipe
Fabiano Flauto
,
Giustina Ferone
,
Maria Cristina De Martino
,
Rosario Pivonello
,
Annamaria Colao
,
Vincenzo Damiano
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202502.0847.v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202502.0847.v1
Adrenocortical carcinomas (ACCs) are rare adrenal tumors that occur in hereditary syndromes or sporadically. Even in sporadic cases, somatic alterations in known susceptibility genes are often detected, emphasizing the growing role of genomic profiling. Recent evidence indicates that ACCs vary in their pathogenetic mechanisms, biochemical phenotype, metastatic potential, and prognosis. While surgery remains the primary treatment for localized ACCs, multiple therapeutic options exist for advanced or metastatic disease, although robust prospective data supporting a genomic profiling-oriented approach are still lacking. To enhance personalized management and improve outcomes in this molecularly complex disease, routine genetic testing for germline mutations along with comprehensive genome profiling for somatic mutations and cluster identification should become standard clinical practice. This review summarizes current evidence on ACC diagnosis and treatment, underscoring the need for a more personalized, cluster-based approach in clinical practice.
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https://openalex.org/W4407358906Canonical identifier for this work in OpenAlex
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https://doi.org/10.20944/preprints202502.0847.v1Digital Object Identifier
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The Management of Adrenocortical Carcinomas in The Era of Precision MedicineWork title
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preprintOpenAlex work type
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2025Year of publication
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2025-02-11Full publication date if available
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Fabiano Flauto, Giustina Ferone, Maria Cristina De Martino, Rosario Pivonello, Annamaria Colao, Vincenzo DamianoList of authors in order
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https://doi.org/10.20944/preprints202502.0847.v1Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.20944/preprints202502.0847.v1Direct OA link when available
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Adrenocortical carcinoma, Precision medicine, Medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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