The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling Article Swipe
D. Garrett Brown
,
Raymond Soto
,
Soumya S. Yandamuri
,
Colleen Stone
,
Laura L. Dickey
,
João Carlos Gomes‐Neto
,
Elissa D. Pastuzyn
,
Rickesha Bell
,
Charisse Petersen
,
Kaitlin Buhrke
,
Robert S. Fujinami
,
Ryan M. O’Connell
,
W. Zac Stephens
,
Jason D. Shepherd
,
Thomas E. Lane
,
June L. Round
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.7554/elife.47117
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.7554/elife.47117
Symbiotic microbes impact the function and development of the central nervous system (CNS); however, little is known about the contribution of the microbiota during viral-induced neurologic damage. We identify that commensals aid in host defense following infection with a neurotropic virus through enhancing microglia function. Germfree mice or animals that receive antibiotics are unable to control viral replication within the brain leading to increased paralysis. Microglia derived from germfree or antibiotic-treated animals cannot stimulate viral-specific immunity and microglia depletion leads to worsened demyelination. Oral administration of toll-like receptor (TLR) ligands to virally infected germfree mice limits neurologic damage. Homeostatic activation of microglia is dependent on intrinsic signaling through TLR4, as disruption of TLR4 within microglia, but not the entire CNS (excluding microglia), leads to increased viral-induced clinical disease. This work demonstrates that gut immune-stimulatory products can influence microglia function to prevent CNS damage following viral infection.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.47117
- OA Status
- gold
- Cited By
- 55
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2958193154
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2958193154Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7554/elife.47117Digital Object Identifier
- Title
-
The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signalingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-07-15Full publication date if available
- Authors
-
D. Garrett Brown, Raymond Soto, Soumya S. Yandamuri, Colleen Stone, Laura L. Dickey, João Carlos Gomes‐Neto, Elissa D. Pastuzyn, Rickesha Bell, Charisse Petersen, Kaitlin Buhrke, Robert S. Fujinami, Ryan M. O’Connell, W. Zac Stephens, Jason D. Shepherd, Thomas E. Lane, June L. RoundList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.47117Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7554/elife.47117Direct OA link when available
- Concepts
-
Microglia, Immune system, TLR4, Biology, Immunology, Innate immune system, Gut–brain axis, Viral replication, Immunity, Central nervous system, Virus, Inflammation, NeuroscienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
55Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2024: 6, 2023: 7, 2022: 8, 2021: 9Per-year citation counts (last 5 years)
- References (count)
-
73Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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