The Microcephaly Epidemic Research Group Paediatric Cohort (MERG–PC): A Cohort Profile Article Swipe
YOU?
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· 2021
· Open Access
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· DOI: https://doi.org/10.3390/v13040602
This cohort profile aims to describe the ongoing follow-up of children in the Microcephaly Epidemic Research Group Paediatric Cohort (MERG–PC). The profile details the context and aims of the study, study population, methodology including assessments, and key results and publications to date. The children that make up MERG–PC were born in Recife or within 120 km of the city, in Pernambuco/Brazil, the epicentre of the microcephaly epidemic. MERG–PC includes children from four groups recruited at different stages of the ZIKV microcephaly epidemic in Pernambuco, i.e., the Outpatient Group (OG/n = 195), the Microcephaly Case–Control Study (MCCS/n = 80), the MERG Pregnant Women Cohort (MERG-PWC/n = 336), and the Control Group (CG/n = 100). We developed a comprehensive array of clinical, laboratory, and imaging assessments that were undertaken by a ‘task force’ of clinical specialists in a single day at 3, 6, 12, 18 months of age, and annually from 24 months. Children from MCCS and CG had their baseline assessment at birth and children from the other groups, at the first evaluation by the task force. The baseline cohort includes 711 children born between February 2015 and February 2019. Children’s characteristics at baseline, excluding CG, were as follows: 32.6% (184/565) had microcephaly, 47% (263/559) had at least one physical abnormality, 29.5% (160/543) had at least one neurological abnormality, and 46.2% (257/556) had at least one ophthalmological abnormality. This ongoing cohort has contributed to the understanding of the congenital Zika syndrome (CZS) spectrum. The cohort has provided descriptions of paediatric neurodevelopment and early epilepsy, including EEG patterns and treatment response, and information on the frequency and characteristics of oropharyngeal dysphagia; cryptorchidism and its surgical findings; endocrine dysfunction; and adenoid hypertrophy in children with Zika-related microcephaly. The study protocols and questionnaires were shared across Brazilian states to enable harmonization across the different studies investigating microcephaly and CZS, providing the opportunity for the Zika Brazilian Cohorts Consortium to be formed, uniting all the ZIKV clinical cohorts in Brazil.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/v13040602
- https://www.mdpi.com/1999-4915/13/4/602/pdf?version=1617939264
- OA Status
- gold
- Cited By
- 8
- References
- 21
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3141306933
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3141306933Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/v13040602Digital Object Identifier
- Title
-
The Microcephaly Epidemic Research Group Paediatric Cohort (MERG–PC): A Cohort ProfileWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-04-01Full publication date if available
- Authors
-
Demócrito de Barros Miranda-Filho, Elizabeth B. Brickley, Anna Ramond, Celina Maria Turchi Martelli, Nuria Sánchez Clemente, Thália Velho Barreto de Araújo, Laura C. Rodrigues, Ulísses Ramos Montarroyos, Wayner Vieira de Souza, Maria de Fátima Pessoa Militão de Albuquerque, Liana O. Ventura, Ernesto T. A. Marques, Mariana de Carvalho Leal Gouveia, Sophie Helena Eickmann, Maria Wanderley Rocha, Paula Fabiana Sobral da Silva, Maria Gomes Carvalho, Regina Coeli Ferreira Ramos, Danielle da Silva Oliveira, M.P.T.P. Xavier, Rômulo A. L. de Vasconcelos, Andréia Veras Gonçalves, Alessandra Mertens Brainer, Marli Tenório Cordeiro, Ricardo Arraes de Alencar XimenesList of authors in order
- Landing page
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https://doi.org/10.3390/v13040602Publisher landing page
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https://www.mdpi.com/1999-4915/13/4/602/pdf?version=1617939264Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4915/13/4/602/pdf?version=1617939264Direct OA link when available
- Concepts
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Cohort, Microcephaly, Medicine, Cohort study, Pediatrics, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 1, 2022: 3, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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21Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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