The Microenvironment of Decellularized Extracellular Matrix from Heart Failure Myocardium Alters the Balance between Angiogenic and Fibrotic Signals from Stromal Primitive Cells Article Swipe
Immacolata Belviso
,
Francesco Angelini
,
Franca Di Meglio
,
Vittorio Picchio
,
Anna Maria Sacco
,
Cristina Nocella
,
Veronica Romano
,
Daria Nurzyńska
,
Giacomo Frati
,
Ciro Maiello
,
Elisa Messina
,
Stefania Montagnani
,
Francesca Pagano
,
Clotilde Castaldo
,
Isotta Chimenti
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/ijms21217903
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/ijms21217903
Cardiac adverse remodeling is characterized by biological changes that affect the composition and architecture of the extracellular matrix (ECM). The consequently disrupted signaling can interfere with the balance between cardiogenic and pro-fibrotic phenotype of resident cardiac stromal primitive cells (CPCs). The latter are important players in cardiac homeostasis and can be exploited as therapeutic cells in regenerative medicine. Our aim was to compare the effects of human decellularized native ECM from normal (dECM-NH) or failing hearts (dECM-PH) on human CPCs. CPCs were cultured on dECM sections and characterized for gene expression, immunofluorescence, and paracrine profiles. When cultured on dECM-NH, CPCs significantly upregulated cardiac commitment markers (CX43, NKX2.5), cardioprotective cytokines (bFGF, HGF), and the angiogenesis mediator, NO. When seeded on dECM-PH, instead, CPCs upregulated pro-remodeling cytokines (IGF-2, PDGF-AA, TGF-β) and the oxidative stress molecule H2O2. Interestingly, culture on dECM-PH was associated with impaired paracrine support to angiogenesis, and increased expression of the vascular endothelial growth factor (VEGF)-sequestering decoy isoform of the KDR/VEGFR2 receptor. Our results suggest that resident CPCs exposed to the pathological microenvironment of remodeling ECM partially lose their paracrine angiogenic properties and release more pro-fibrotic cytokines. These observations shed novel insights on the crosstalk between ECM and stromal CPCs, suggesting also a cautious use of non-healthy decellularized myocardium for cardiac tissue engineering approaches.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms21217903
- https://www.mdpi.com/1422-0067/21/21/7903/pdf?version=1603679365
- OA Status
- gold
- Cited By
- 29
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3094602551
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3094602551Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms21217903Digital Object Identifier
- Title
-
The Microenvironment of Decellularized Extracellular Matrix from Heart Failure Myocardium Alters the Balance between Angiogenic and Fibrotic Signals from Stromal Primitive CellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-10-24Full publication date if available
- Authors
-
Immacolata Belviso, Francesco Angelini, Franca Di Meglio, Vittorio Picchio, Anna Maria Sacco, Cristina Nocella, Veronica Romano, Daria Nurzyńska, Giacomo Frati, Ciro Maiello, Elisa Messina, Stefania Montagnani, Francesca Pagano, Clotilde Castaldo, Isotta ChimentiList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms21217903Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/21/21/7903/pdf?version=1603679365Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/21/21/7903/pdf?version=1603679365Direct OA link when available
- Concepts
-
Decellularization, Paracrine signalling, Cell biology, Extracellular matrix, Angiogenesis, Stromal cell, Autocrine signalling, Biology, Chemistry, Cancer research, Receptor, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
29Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 8, 2023: 7, 2022: 8, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
66Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3094602551 |
|---|---|
| doi | https://doi.org/10.3390/ijms21217903 |
| ids.doi | https://doi.org/10.3390/ijms21217903 |
| ids.mag | 3094602551 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33114386 |
| ids.openalex | https://openalex.org/W3094602551 |
| fwci | 4.43249344 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000328 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Adult |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000368 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Aged |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D000818 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Animals |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D002470 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Cell Survival |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D002478 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Cells, Cultured |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D018920 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Coculture Techniques |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D016207 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | Cytokines |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D016207 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Cytokines |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D005109 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Extracellular Matrix |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D005109 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Extracellular Matrix |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D005260 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Female |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D005355 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Fibrosis |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D006333 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | Heart Failure |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D006333 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Heart Failure |
| mesh[14].qualifier_ui | Q000473 |
| mesh[14].descriptor_ui | D006333 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | pathology |
| mesh[14].descriptor_name | Heart Failure |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D006801 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Humans |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D006861 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | Hydrogen Peroxide |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D008297 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Male |
| mesh[18].qualifier_ui | Q000166 |
| mesh[18].descriptor_ui | D059630 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | cytology |
| mesh[18].descriptor_name | Mesenchymal Stem Cells |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D059630 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Mesenchymal Stem Cells |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D008875 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Middle Aged |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000328 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Adult |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D000368 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Aged |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D000818 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Animals |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D002470 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Cell Survival |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D002478 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Cells, Cultured |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D018920 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Coculture Techniques |
| mesh[27].qualifier_ui | Q000235 |
| mesh[27].descriptor_ui | D016207 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | genetics |
| mesh[27].descriptor_name | Cytokines |
| mesh[28].qualifier_ui | Q000378 |
| mesh[28].descriptor_ui | D016207 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | metabolism |
| mesh[28].descriptor_name | Cytokines |
| mesh[29].qualifier_ui | Q000235 |
| mesh[29].descriptor_ui | D005109 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | genetics |
| mesh[29].descriptor_name | Extracellular Matrix |
| mesh[30].qualifier_ui | Q000378 |
| mesh[30].descriptor_ui | D005109 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | metabolism |
| mesh[30].descriptor_name | Extracellular Matrix |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D005260 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Female |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D005355 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Fibrosis |
| mesh[33].qualifier_ui | Q000235 |
| mesh[33].descriptor_ui | D006333 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | genetics |
| mesh[33].descriptor_name | Heart Failure |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D006333 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Heart Failure |
| mesh[35].qualifier_ui | Q000473 |
| mesh[35].descriptor_ui | D006333 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | pathology |
| mesh[35].descriptor_name | Heart Failure |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D006801 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Humans |
| mesh[37].qualifier_ui | Q000378 |
| mesh[37].descriptor_ui | D006861 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | metabolism |
| mesh[37].descriptor_name | Hydrogen Peroxide |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D008297 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Male |
| mesh[39].qualifier_ui | Q000166 |
| mesh[39].descriptor_ui | D059630 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | cytology |
| mesh[39].descriptor_name | Mesenchymal Stem Cells |
| mesh[40].qualifier_ui | Q000378 |
| mesh[40].descriptor_ui | D059630 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | metabolism |
| mesh[40].descriptor_name | Mesenchymal Stem Cells |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D008875 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Middle Aged |
| type | article |
| title | The Microenvironment of Decellularized Extracellular Matrix from Heart Failure Myocardium Alters the Balance between Angiogenic and Fibrotic Signals from Stromal Primitive Cells |
| biblio.issue | 21 |
| biblio.volume | 21 |
| biblio.last_page | 7903 |
| biblio.first_page | 7903 |
| grants[0].funder | https://openalex.org/F4320321873 |
| grants[0].award_id | 20123E8FH4 |
| grants[0].funder_display_name | Ministero dell’Istruzione, dell’Università e della Ricerca |
| grants[1].funder | https://openalex.org/F4320322510 |
| grants[1].award_id | RG11916B85CDBF76 |
| grants[1].funder_display_name | Sapienza Università di Roma |
| topics[0].id | https://openalex.org/T12264 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2746 |
| topics[0].subfield.display_name | Surgery |
| topics[0].display_name | Tissue Engineering and Regenerative Medicine |
| topics[1].id | https://openalex.org/T10729 |
| topics[1].field.id | https://openalex.org/fields/25 |
| topics[1].field.display_name | Materials Science |
| topics[1].score | 0.9980000257492065 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2502 |
| topics[1].subfield.display_name | Biomaterials |
| topics[1].display_name | Electrospun Nanofibers in Biomedical Applications |
| topics[2].id | https://openalex.org/T11962 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.993399977684021 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2705 |
| topics[2].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[2].display_name | Cardiac Fibrosis and Remodeling |
| funders[0].id | https://openalex.org/F4320321873 |
| funders[0].ror | https://ror.org/0166hxq48 |
| funders[0].display_name | Ministero dell’Istruzione, dell’Università e della Ricerca |
| funders[1].id | https://openalex.org/F4320322510 |
| funders[1].ror | https://ror.org/02be6w209 |
| funders[1].display_name | Sapienza Università di Roma |
| is_xpac | False |
| apc_list.value | 2300 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2300 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2490 |
| concepts[0].id | https://openalex.org/C190672674 |
| concepts[0].level | 3 |
| concepts[0].score | 0.9209771752357483 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q3866591 |
| concepts[0].display_name | Decellularization |
| concepts[1].id | https://openalex.org/C7876069 |
| concepts[1].level | 3 |
| concepts[1].score | 0.8137280941009521 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q14873666 |
| concepts[1].display_name | Paracrine signalling |
| concepts[2].id | https://openalex.org/C95444343 |
| concepts[2].level | 1 |
| concepts[2].score | 0.7493459582328796 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[2].display_name | Cell biology |
| concepts[3].id | https://openalex.org/C189165786 |
| concepts[3].level | 2 |
| concepts[3].score | 0.7004095315933228 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q193825 |
| concepts[3].display_name | Extracellular matrix |
| concepts[4].id | https://openalex.org/C2780394083 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6699872016906738 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q539568 |
| concepts[4].display_name | Angiogenesis |
| concepts[5].id | https://openalex.org/C16930146 |
| concepts[5].level | 2 |
| concepts[5].score | 0.6309382915496826 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q4381253 |
| concepts[5].display_name | Stromal cell |
| concepts[6].id | https://openalex.org/C128240485 |
| concepts[6].level | 3 |
| concepts[6].score | 0.48765313625335693 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q786998 |
| concepts[6].display_name | Autocrine signalling |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.46199584007263184 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C185592680 |
| concepts[8].level | 0 |
| concepts[8].score | 0.36629438400268555 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[8].display_name | Chemistry |
| concepts[9].id | https://openalex.org/C502942594 |
| concepts[9].level | 1 |
| concepts[9].score | 0.34936124086380005 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[9].display_name | Cancer research |
| concepts[10].id | https://openalex.org/C170493617 |
| concepts[10].level | 2 |
| concepts[10].score | 0.12799391150474548 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[10].display_name | Receptor |
| concepts[11].id | https://openalex.org/C55493867 |
| concepts[11].level | 1 |
| concepts[11].score | 0.09573358297348022 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[11].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/decellularization |
| keywords[0].score | 0.9209771752357483 |
| keywords[0].display_name | Decellularization |
| keywords[1].id | https://openalex.org/keywords/paracrine-signalling |
| keywords[1].score | 0.8137280941009521 |
| keywords[1].display_name | Paracrine signalling |
| keywords[2].id | https://openalex.org/keywords/cell-biology |
| keywords[2].score | 0.7493459582328796 |
| keywords[2].display_name | Cell biology |
| keywords[3].id | https://openalex.org/keywords/extracellular-matrix |
| keywords[3].score | 0.7004095315933228 |
| keywords[3].display_name | Extracellular matrix |
| keywords[4].id | https://openalex.org/keywords/angiogenesis |
| keywords[4].score | 0.6699872016906738 |
| keywords[4].display_name | Angiogenesis |
| keywords[5].id | https://openalex.org/keywords/stromal-cell |
| keywords[5].score | 0.6309382915496826 |
| keywords[5].display_name | Stromal cell |
| keywords[6].id | https://openalex.org/keywords/autocrine-signalling |
| keywords[6].score | 0.48765313625335693 |
| keywords[6].display_name | Autocrine signalling |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.46199584007263184 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/chemistry |
| keywords[8].score | 0.36629438400268555 |
| keywords[8].display_name | Chemistry |
| keywords[9].id | https://openalex.org/keywords/cancer-research |
| keywords[9].score | 0.34936124086380005 |
| keywords[9].display_name | Cancer research |
| keywords[10].id | https://openalex.org/keywords/receptor |
| keywords[10].score | 0.12799391150474548 |
| keywords[10].display_name | Receptor |
| keywords[11].id | https://openalex.org/keywords/biochemistry |
| keywords[11].score | 0.09573358297348022 |
| keywords[11].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.3390/ijms21217903 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S10623703 |
| locations[0].source.issn | 1422-0067, 1661-6596 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1422-0067 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | International Journal of Molecular Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1422-0067/21/21/7903/pdf?version=1603679365 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | International Journal of Molecular Sciences |
| locations[0].landing_page_url | https://doi.org/10.3390/ijms21217903 |
| locations[1].id | pmid:33114386 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | International journal of molecular sciences |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33114386 |
| locations[2].id | pmh:oai:iris.uniroma1.it:11573/1461918 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4377196107 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | IRIS Research product catalog (Sapienza University of Rome) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | other-oa |
| locations[2].pdf_url | http://hdl.handle.net/11573/1461918 |
| locations[2].version | submittedVersion |
| locations[2].raw_type | info:eu-repo/semantics/article |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | http://hdl.handle.net/11573/1461918 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:7662394 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Int J Mol Sci |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7662394 |
| locations[4].id | pmh:oai:mdpi.com:/1422-0067/21/21/7903/ |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306400947 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | True |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | MDPI (MDPI AG) |
| locations[4].source.host_organization | https://openalex.org/I4210097602 |
| locations[4].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[4].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[4].license | cc-by |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/cc-by |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | International Journal of Molecular Sciences; Volume 21; Issue 21; Pages: 7903 |
| locations[4].landing_page_url | https://dx.doi.org/10.3390/ijms21217903 |
| locations[5].id | pmh:oai:doaj.org/article:469f43a81c494ce582ad922304ea15d7 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306401280 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[5].source.host_organization | |
| locations[5].source.host_organization_name | |
| locations[5].source.host_organization_lineage | |
| locations[5].license | cc-by-sa |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | article |
| locations[5].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | International Journal of Molecular Sciences, Vol 21, Iss 7903, p 7903 (2020) |
| locations[5].landing_page_url | https://doaj.org/article/469f43a81c494ce582ad922304ea15d7 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5082045616 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Immacolata Belviso |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I71267560 |
| authorships[0].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | University of Naples Federico II |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Immacolata Belviso |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[1].author.id | https://openalex.org/A5043863764 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-0052-6956 |
| authorships[1].author.display_name | Francesco Angelini |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210128630 |
| authorships[1].affiliations[0].raw_affiliation_string | Experimental and Clinical Pharmacology Unit, CRO-National Cancer Institute, 33081 Aviano (PN), Italy |
| authorships[1].institutions[0].id | https://openalex.org/I4210128630 |
| authorships[1].institutions[0].ror | https://ror.org/03ks1vk59 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210128630, https://openalex.org/I4210153126 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | Centro di Riferimento Oncologico |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Francesco Angelini |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Experimental and Clinical Pharmacology Unit, CRO-National Cancer Institute, 33081 Aviano (PN), Italy |
| authorships[2].author.id | https://openalex.org/A5010365778 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-9793-9289 |
| authorships[2].author.display_name | Franca Di Meglio |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[2].institutions[0].id | https://openalex.org/I71267560 |
| authorships[2].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | University of Naples Federico II |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Franca Di Meglio |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[3].author.id | https://openalex.org/A5075625139 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-1591-5118 |
| authorships[3].author.display_name | Vittorio Picchio |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Medical Surgical Sciences and Biotechnologies, Sapienza University, Corso della Repubblica 79, 04100 Latina, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I861853513 |
| authorships[3].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | Sapienza University of Rome |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Vittorio Picchio |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Medical Surgical Sciences and Biotechnologies, Sapienza University, Corso della Repubblica 79, 04100 Latina, Italy |
| authorships[4].author.id | https://openalex.org/A5063304847 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-5598-1841 |
| authorships[4].author.display_name | Anna Maria Sacco |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[4].institutions[0].id | https://openalex.org/I71267560 |
| authorships[4].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | University of Naples Federico II |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Anna Maria Sacco |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[5].author.id | https://openalex.org/A5080617759 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-4398-6327 |
| authorships[5].author.display_name | Cristina Nocella |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University, 00161 Rome, Italy |
| authorships[5].institutions[0].id | https://openalex.org/I861853513 |
| authorships[5].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | Sapienza University of Rome |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Cristina Nocella |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University, 00161 Rome, Italy |
| authorships[6].author.id | https://openalex.org/A5103972863 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-2015-9305 |
| authorships[6].author.display_name | Veronica Romano |
| authorships[6].countries | IT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[6].institutions[0].id | https://openalex.org/I71267560 |
| authorships[6].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[6].institutions[0].country_code | IT |
| authorships[6].institutions[0].display_name | University of Naples Federico II |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Veronica Romano |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[7].author.id | https://openalex.org/A5089804124 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-1092-6168 |
| authorships[7].author.display_name | Daria Nurzyńska |
| authorships[7].countries | IT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[7].institutions[0].id | https://openalex.org/I71267560 |
| authorships[7].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[7].institutions[0].country_code | IT |
| authorships[7].institutions[0].display_name | University of Naples Federico II |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Daria Nurzynska |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[8].author.id | https://openalex.org/A5082527578 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-2703-3761 |
| authorships[8].author.display_name | Giacomo Frati |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Medical Surgical Sciences and Biotechnologies, Sapienza University, Corso della Repubblica 79, 04100 Latina, Italy |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I3018288129 |
| authorships[8].affiliations[1].raw_affiliation_string | Department of AngioCardioNeurology, IRCCS Neuromed, 86077 Pozzilli, Italy |
| authorships[8].institutions[0].id | https://openalex.org/I3018288129 |
| authorships[8].institutions[0].ror | https://ror.org/00cpb6264 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I3018288129, https://openalex.org/I4210153126 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | Istituto Neurologico Mediterraneo |
| authorships[8].institutions[1].id | https://openalex.org/I861853513 |
| authorships[8].institutions[1].ror | https://ror.org/02be6w209 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I861853513 |
| authorships[8].institutions[1].country_code | IT |
| authorships[8].institutions[1].display_name | Sapienza University of Rome |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Giacomo Frati |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of AngioCardioNeurology, IRCCS Neuromed, 86077 Pozzilli, Italy, Department of Medical Surgical Sciences and Biotechnologies, Sapienza University, Corso della Repubblica 79, 04100 Latina, Italy |
| authorships[9].author.id | https://openalex.org/A5087324234 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-1604-4756 |
| authorships[9].author.display_name | Ciro Maiello |
| authorships[9].countries | IT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210140815 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Cardiovascular Surgery and Transplant, Monaldi Hospital, 80131 Naples, Italy |
| authorships[9].institutions[0].id | https://openalex.org/I4210140815 |
| authorships[9].institutions[0].ror | https://ror.org/0560hqd63 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210140815 |
| authorships[9].institutions[0].country_code | IT |
| authorships[9].institutions[0].display_name | Ospedale Monaldi |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Ciro Maiello |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Cardiovascular Surgery and Transplant, Monaldi Hospital, 80131 Naples, Italy |
| authorships[10].author.id | https://openalex.org/A5081979748 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-1654-9001 |
| authorships[10].author.display_name | Elisa Messina |
| authorships[10].countries | IT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I2800330116 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Maternal Infantile and Urological Sciences, "Umberto I" Hospital, 00161 Rome, Italy |
| authorships[10].institutions[0].id | https://openalex.org/I2800330116 |
| authorships[10].institutions[0].ror | https://ror.org/011cabk38 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I2800330116 |
| authorships[10].institutions[0].country_code | IT |
| authorships[10].institutions[0].display_name | Policlinico Umberto I |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Elisa Messina |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Maternal Infantile and Urological Sciences, "Umberto I" Hospital, 00161 Rome, Italy |
| authorships[11].author.id | https://openalex.org/A5091033376 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-7420-372X |
| authorships[11].author.display_name | Stefania Montagnani |
| authorships[11].countries | IT |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[11].institutions[0].id | https://openalex.org/I71267560 |
| authorships[11].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[11].institutions[0].country_code | IT |
| authorships[11].institutions[0].display_name | University of Naples Federico II |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Stefania Montagnani |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[12].author.id | https://openalex.org/A5054249637 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-1956-5864 |
| authorships[12].author.display_name | Francesca Pagano |
| authorships[12].countries | IT |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I4210155481 |
| authorships[12].affiliations[0].raw_affiliation_string | Institute of Biochemistry and Cell Biology, National Council of Research (IBBC-CNR), 00015 Monterotondo (RM), Italy |
| authorships[12].institutions[0].id | https://openalex.org/I4210155481 |
| authorships[12].institutions[0].ror | https://ror.org/040xhth73 |
| authorships[12].institutions[0].type | facility |
| authorships[12].institutions[0].lineage | https://openalex.org/I4210155236, https://openalex.org/I4210155481 |
| authorships[12].institutions[0].country_code | IT |
| authorships[12].institutions[0].display_name | Institute of Cell Biology and Neurobiology |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Francesca Pagano |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Institute of Biochemistry and Cell Biology, National Council of Research (IBBC-CNR), 00015 Monterotondo (RM), Italy |
| authorships[13].author.id | https://openalex.org/A5042356408 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-1475-5036 |
| authorships[13].author.display_name | Clotilde Castaldo |
| authorships[13].countries | IT |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I71267560 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[13].institutions[0].id | https://openalex.org/I71267560 |
| authorships[13].institutions[0].ror | https://ror.org/05290cv24 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I71267560 |
| authorships[13].institutions[0].country_code | IT |
| authorships[13].institutions[0].display_name | University of Naples Federico II |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Clotilde Castaldo |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Public Health, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy |
| authorships[14].author.id | https://openalex.org/A5089315387 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-0865-8814 |
| authorships[14].author.display_name | Isotta Chimenti |
| authorships[14].countries | IT |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Medical Surgical Sciences and Biotechnologies, Sapienza University, Corso della Repubblica 79, 04100 Latina, Italy |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I4210121996 |
| authorships[14].affiliations[1].raw_affiliation_string | Mediterranea Cardiocentro, 80122 Napoli, Italy |
| authorships[14].institutions[0].id | https://openalex.org/I4210121996 |
| authorships[14].institutions[0].ror | https://ror.org/03pxvf904 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210121996 |
| authorships[14].institutions[0].country_code | IT |
| authorships[14].institutions[0].display_name | Clinica Mediterranea |
| authorships[14].institutions[1].id | https://openalex.org/I861853513 |
| authorships[14].institutions[1].ror | https://ror.org/02be6w209 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I861853513 |
| authorships[14].institutions[1].country_code | IT |
| authorships[14].institutions[1].display_name | Sapienza University of Rome |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Isotta Chimenti |
| authorships[14].is_corresponding | True |
| authorships[14].raw_affiliation_strings | Department of Medical Surgical Sciences and Biotechnologies, Sapienza University, Corso della Repubblica 79, 04100 Latina, Italy, Mediterranea Cardiocentro, 80122 Napoli, Italy |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1422-0067/21/21/7903/pdf?version=1603679365 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | The Microenvironment of Decellularized Extracellular Matrix from Heart Failure Myocardium Alters the Balance between Angiogenic and Fibrotic Signals from Stromal Primitive Cells |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12264 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2746 |
| primary_topic.subfield.display_name | Surgery |
| primary_topic.display_name | Tissue Engineering and Regenerative Medicine |
| related_works | https://openalex.org/W2077879126, https://openalex.org/W2091727603, https://openalex.org/W2085869617, https://openalex.org/W3004047898, https://openalex.org/W2015867957, https://openalex.org/W2367035282, https://openalex.org/W1996832816, https://openalex.org/W1963652002, https://openalex.org/W4395698853, https://openalex.org/W1969354036 |
| cited_by_count | 29 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 8 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 7 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 8 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 3 |
| locations_count | 6 |
| best_oa_location.id | doi:10.3390/ijms21217903 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S10623703 |
| best_oa_location.source.issn | 1422-0067, 1661-6596 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1422-0067 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | International Journal of Molecular Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1422-0067/21/21/7903/pdf?version=1603679365 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | International Journal of Molecular Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.3390/ijms21217903 |
| primary_location.id | doi:10.3390/ijms21217903 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S10623703 |
| primary_location.source.issn | 1422-0067, 1661-6596 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1422-0067 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | International Journal of Molecular Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1422-0067/21/21/7903/pdf?version=1603679365 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | International Journal of Molecular Sciences |
| primary_location.landing_page_url | https://doi.org/10.3390/ijms21217903 |
| publication_date | 2020-10-24 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W1908289777, https://openalex.org/W2728290384, https://openalex.org/W2165270605, https://openalex.org/W2608650231, https://openalex.org/W2805466622, https://openalex.org/W1584289387, https://openalex.org/W2789758986, https://openalex.org/W2607293733, https://openalex.org/W2756100735, https://openalex.org/W2011256210, https://openalex.org/W2799685857, https://openalex.org/W2042654902, https://openalex.org/W1997438305, https://openalex.org/W2339818492, https://openalex.org/W2094334737, https://openalex.org/W1550942300, https://openalex.org/W2772646551, https://openalex.org/W2887254063, https://openalex.org/W2412177040, https://openalex.org/W6713814183, https://openalex.org/W2575761878, https://openalex.org/W2008724145, https://openalex.org/W2033082029, https://openalex.org/W2089964098, https://openalex.org/W2948663403, https://openalex.org/W2157457715, https://openalex.org/W2739786285, https://openalex.org/W2549581480, https://openalex.org/W2033474014, https://openalex.org/W2596186147, https://openalex.org/W3083550073, https://openalex.org/W2181778634, https://openalex.org/W3012301331, https://openalex.org/W2104925999, https://openalex.org/W2730906387, https://openalex.org/W2168488590, https://openalex.org/W2134473118, https://openalex.org/W2026949272, https://openalex.org/W2340389851, https://openalex.org/W2792088252, https://openalex.org/W2004484755, https://openalex.org/W1964005024, https://openalex.org/W2406061823, https://openalex.org/W2001158990, https://openalex.org/W2787415053, https://openalex.org/W2030828007, https://openalex.org/W2148608806, https://openalex.org/W1975841469, https://openalex.org/W2028836208, https://openalex.org/W2742679647, https://openalex.org/W2805927967, https://openalex.org/W2120856680, https://openalex.org/W1561501622, https://openalex.org/W2064736515, https://openalex.org/W2069464185, https://openalex.org/W2887191177, https://openalex.org/W2180493842, https://openalex.org/W1925073355, https://openalex.org/W2725351602, https://openalex.org/W2555693724, https://openalex.org/W1967934065, https://openalex.org/W2999082132, https://openalex.org/W1972408351, https://openalex.org/W2923660809, https://openalex.org/W2598386705, https://openalex.org/W2940084731 |
| referenced_works_count | 66 |
| abstract_inverted_index.a | 202 |
| abstract_inverted_index.as | 52 |
| abstract_inverted_index.be | 50 |
| abstract_inverted_index.by | 5 |
| abstract_inverted_index.in | 45, 55 |
| abstract_inverted_index.is | 3 |
| abstract_inverted_index.of | 14, 33, 65, 149, 158, 173, 205 |
| abstract_inverted_index.on | 77, 83, 97, 118, 136, 192 |
| abstract_inverted_index.or | 73 |
| abstract_inverted_index.to | 61, 144, 169 |
| abstract_inverted_index.ECM | 69, 175, 196 |
| abstract_inverted_index.NO. | 115 |
| abstract_inverted_index.Our | 58, 162 |
| abstract_inverted_index.The | 19, 40 |
| abstract_inverted_index.aim | 59 |
| abstract_inverted_index.and | 12, 30, 48, 86, 92, 111, 128, 146, 182, 197 |
| abstract_inverted_index.are | 42 |
| abstract_inverted_index.can | 23, 49 |
| abstract_inverted_index.for | 88, 209 |
| abstract_inverted_index.the | 10, 15, 26, 63, 112, 129, 150, 159, 170, 193 |
| abstract_inverted_index.use | 204 |
| abstract_inverted_index.was | 60, 138 |
| abstract_inverted_index.CPCs | 80, 99, 121, 167 |
| abstract_inverted_index.When | 95, 116 |
| abstract_inverted_index.also | 201 |
| abstract_inverted_index.dECM | 84 |
| abstract_inverted_index.from | 70 |
| abstract_inverted_index.gene | 89 |
| abstract_inverted_index.lose | 177 |
| abstract_inverted_index.more | 184 |
| abstract_inverted_index.shed | 189 |
| abstract_inverted_index.that | 8, 165 |
| abstract_inverted_index.were | 81 |
| abstract_inverted_index.with | 25, 140 |
| abstract_inverted_index.CPCs, | 199 |
| abstract_inverted_index.CPCs. | 79 |
| abstract_inverted_index.H2O2. | 133 |
| abstract_inverted_index.HGF), | 110 |
| abstract_inverted_index.These | 187 |
| abstract_inverted_index.cells | 38, 54 |
| abstract_inverted_index.decoy | 156 |
| abstract_inverted_index.human | 66, 78 |
| abstract_inverted_index.novel | 190 |
| abstract_inverted_index.their | 178 |
| abstract_inverted_index.(CX43, | 105 |
| abstract_inverted_index.(ECM). | 18 |
| abstract_inverted_index.(bFGF, | 109 |
| abstract_inverted_index.affect | 9 |
| abstract_inverted_index.factor | 154 |
| abstract_inverted_index.growth | 153 |
| abstract_inverted_index.hearts | 75 |
| abstract_inverted_index.latter | 41 |
| abstract_inverted_index.matrix | 17 |
| abstract_inverted_index.native | 68 |
| abstract_inverted_index.normal | 71 |
| abstract_inverted_index.seeded | 117 |
| abstract_inverted_index.stress | 131 |
| abstract_inverted_index.tissue | 211 |
| abstract_inverted_index.(CPCs). | 39 |
| abstract_inverted_index.(IGF-2, | 125 |
| abstract_inverted_index.Cardiac | 0 |
| abstract_inverted_index.TGF-β) | 127 |
| abstract_inverted_index.adverse | 1 |
| abstract_inverted_index.balance | 27 |
| abstract_inverted_index.between | 28, 195 |
| abstract_inverted_index.cardiac | 35, 46, 102, 210 |
| abstract_inverted_index.changes | 7 |
| abstract_inverted_index.compare | 62 |
| abstract_inverted_index.culture | 135 |
| abstract_inverted_index.dECM-PH | 137 |
| abstract_inverted_index.effects | 64 |
| abstract_inverted_index.exposed | 168 |
| abstract_inverted_index.failing | 74 |
| abstract_inverted_index.isoform | 157 |
| abstract_inverted_index.markers | 104 |
| abstract_inverted_index.players | 44 |
| abstract_inverted_index.release | 183 |
| abstract_inverted_index.results | 163 |
| abstract_inverted_index.stromal | 36, 198 |
| abstract_inverted_index.suggest | 164 |
| abstract_inverted_index.support | 143 |
| abstract_inverted_index.NKX2.5), | 106 |
| abstract_inverted_index.PDGF-AA, | 126 |
| abstract_inverted_index.cautious | 203 |
| abstract_inverted_index.cultured | 82, 96 |
| abstract_inverted_index.dECM-NH, | 98 |
| abstract_inverted_index.dECM-PH, | 119 |
| abstract_inverted_index.impaired | 141 |
| abstract_inverted_index.insights | 191 |
| abstract_inverted_index.instead, | 120 |
| abstract_inverted_index.molecule | 132 |
| abstract_inverted_index.resident | 34, 166 |
| abstract_inverted_index.sections | 85 |
| abstract_inverted_index.vascular | 151 |
| abstract_inverted_index.(dECM-NH) | 72 |
| abstract_inverted_index.(dECM-PH) | 76 |
| abstract_inverted_index.crosstalk | 194 |
| abstract_inverted_index.cytokines | 108, 124 |
| abstract_inverted_index.disrupted | 21 |
| abstract_inverted_index.exploited | 51 |
| abstract_inverted_index.important | 43 |
| abstract_inverted_index.increased | 147 |
| abstract_inverted_index.interfere | 24 |
| abstract_inverted_index.mediator, | 114 |
| abstract_inverted_index.medicine. | 57 |
| abstract_inverted_index.oxidative | 130 |
| abstract_inverted_index.paracrine | 93, 142, 179 |
| abstract_inverted_index.partially | 176 |
| abstract_inverted_index.phenotype | 32 |
| abstract_inverted_index.primitive | 37 |
| abstract_inverted_index.profiles. | 94 |
| abstract_inverted_index.receptor. | 161 |
| abstract_inverted_index.signaling | 22 |
| abstract_inverted_index.KDR/VEGFR2 | 160 |
| abstract_inverted_index.angiogenic | 180 |
| abstract_inverted_index.associated | 139 |
| abstract_inverted_index.biological | 6 |
| abstract_inverted_index.commitment | 103 |
| abstract_inverted_index.cytokines. | 186 |
| abstract_inverted_index.expression | 148 |
| abstract_inverted_index.myocardium | 208 |
| abstract_inverted_index.properties | 181 |
| abstract_inverted_index.remodeling | 2, 174 |
| abstract_inverted_index.suggesting | 200 |
| abstract_inverted_index.approaches. | 213 |
| abstract_inverted_index.cardiogenic | 29 |
| abstract_inverted_index.composition | 11 |
| abstract_inverted_index.endothelial | 152 |
| abstract_inverted_index.engineering | 212 |
| abstract_inverted_index.expression, | 90 |
| abstract_inverted_index.homeostasis | 47 |
| abstract_inverted_index.non-healthy | 206 |
| abstract_inverted_index.therapeutic | 53 |
| abstract_inverted_index.upregulated | 101, 122 |
| abstract_inverted_index.angiogenesis | 113 |
| abstract_inverted_index.architecture | 13 |
| abstract_inverted_index.consequently | 20 |
| abstract_inverted_index.observations | 188 |
| abstract_inverted_index.pathological | 171 |
| abstract_inverted_index.pro-fibrotic | 31, 185 |
| abstract_inverted_index.regenerative | 56 |
| abstract_inverted_index.angiogenesis, | 145 |
| abstract_inverted_index.characterized | 4, 87 |
| abstract_inverted_index.extracellular | 16 |
| abstract_inverted_index.significantly | 100 |
| abstract_inverted_index.Interestingly, | 134 |
| abstract_inverted_index.decellularized | 67, 207 |
| abstract_inverted_index.pro-remodeling | 123 |
| abstract_inverted_index.cardioprotective | 107 |
| abstract_inverted_index.microenvironment | 172 |
| abstract_inverted_index.(VEGF)-sequestering | 155 |
| abstract_inverted_index.immunofluorescence, | 91 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5089315387 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I4210121996, https://openalex.org/I861853513 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7599999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.94071206 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |