Research Square (Research Square)
The molecular mechanism of miRNA-195-5p regulating ERK involvement in abnormal phosphorylation of Tau protein by aluminum maltol in PC12 cells
December 2023 • Dan Gao, Jinzhu Yin, Yunwei Zhang, Dan Zhao, Xiao Han, Jiaping Huan, Tianshu Wang, Shimeng Xu, Linping Wang, Jing Song, Huifang Zhang, Q. L. Niu, Xia…
Abstract Although aluminum is ubiquitously present on Earth, it is not necessary for life. Aluminum is a metal element that can induce neurotoxicity. The neurotoxicity of aluminum is mainly caused by the aggregation of abnormally phosphorylated tau protein to form neurofibrillary tangles (NFT). The phosphorylation of tau is regulated by both kinases and phosphatases. ERK is involved in PHF-type tau hyperphosphorylation. Recent studies have revealed that the interaction between microRNAs (miRNAs) and the ERK/MAPK c…