The Neolignan Honokiol and Its Synthetic Derivative Honokiol Hexafluoro Reduce Neuroinflammation and Cellular Senescence in Microglia Cells Article Swipe
Chiara Sasia
,
Vittoria Borgonetti
,
Caterina Mancini
,
Giulia Lori
,
Jack L. Arbiser
,
Maria Letizia Taddei
,
Nicoletta Galeotti
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cells13191652
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cells13191652
Microglia-mediated neuroinflammation has been linked to neurodegenerative disorders. Inflammation and aging contribute to microglial senescence. Microglial senescence promotes the development of neurodegenerative disorders, including Alzheimer’s disease (AD). In this study, we investigated the anti-neuroinflammatory and anti-senescence activity of Honokiol (HNK), a polyphenolic neolignane from Magnolia officinalis Rehder & E.H Wilson, in comparison with its synthetic analogue Honokiol Hexafluoro (CH). HNK reduced the pro-inflammatory cell morphology of LPS-stimulated BV2 microglia cells and increased the expression of the anti-inflammatory cytokine IL-10 with an efficacy comparable to CH. HNK and CH were also able to attenuate the alterations in cell morphology associated with cellular senescence in BV2 cells intermittently stimulated with LPS and significantly reduce the activity and expression of the senescence marker ß-galactosidase and the expression of p21 and pERK1/2. The treatments reduced the expression of senescence-associated secretory phenotype (SASP) factors IL-1ß and NF-kB, decreased ROS production, and abolished H2AX over phosphorylation (γ-H2AX) and acetylated H3 overexpression. Senescent microglia cells showed an increased expression of the Notch ligand Jagged1 that was reduced by HNK and CH with a comparable efficacy to the Notch inhibitor DAPT. Overall, our data illustrate a protective activity of HNK and CH on neuroinflammation and cellular senescence in microglia cells involving a Notch-signaling-mediated mechanism and suggesting a potential therapeutic contribution in aging-related neurodegenerative diseases.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells13191652
- OA Status
- gold
- Cited By
- 6
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403139989
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403139989Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cells13191652Digital Object Identifier
- Title
-
The Neolignan Honokiol and Its Synthetic Derivative Honokiol Hexafluoro Reduce Neuroinflammation and Cellular Senescence in Microglia CellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-10-04Full publication date if available
- Authors
-
Chiara Sasia, Vittoria Borgonetti, Caterina Mancini, Giulia Lori, Jack L. Arbiser, Maria Letizia Taddei, Nicoletta GaleottiList of authors in order
- Landing page
-
https://doi.org/10.3390/cells13191652Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/cells13191652Direct OA link when available
- Concepts
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Neuroinflammation, Microglia, Honokiol, Senescence, Inflammation, Cellular senescence, Neuroscience, Medicine, Biology, Immunology, Cell biology, Pharmacology, Biochemistry, Phenotype, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6Per-year citation counts (last 5 years)
- References (count)
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64Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.that | 167 |
| abstract_inverted_index.this | 28 |
| abstract_inverted_index.were | 88 |
| abstract_inverted_index.with | 52, 79, 99, 107, 174 |
| abstract_inverted_index.& | 47 |
| abstract_inverted_index.(AD). | 26 |
| abstract_inverted_index.(CH). | 58 |
| abstract_inverted_index.DAPT. | 182 |
| abstract_inverted_index.IL-10 | 78 |
| abstract_inverted_index.Notch | 164, 180 |
| abstract_inverted_index.aging | 10 |
| abstract_inverted_index.cells | 69, 104, 157, 201 |
| abstract_inverted_index.(HNK), | 39 |
| abstract_inverted_index.(SASP) | 137 |
| abstract_inverted_index.IL-1ß | 139 |
| abstract_inverted_index.NF-kB, | 141 |
| abstract_inverted_index.Rehder | 46 |
| abstract_inverted_index.ligand | 165 |
| abstract_inverted_index.linked | 4 |
| abstract_inverted_index.marker | 119 |
| abstract_inverted_index.reduce | 111 |
| abstract_inverted_index.showed | 158 |
| abstract_inverted_index.study, | 29 |
| abstract_inverted_index.Jagged1 | 166 |
| abstract_inverted_index.Wilson, | 49 |
| abstract_inverted_index.disease | 25 |
| abstract_inverted_index.factors | 138 |
| abstract_inverted_index.reduced | 60, 130, 169 |
| abstract_inverted_index.Honokiol | 38, 56 |
| abstract_inverted_index.Magnolia | 44 |
| abstract_inverted_index.Overall, | 183 |
| abstract_inverted_index.activity | 36, 113, 189 |
| abstract_inverted_index.analogue | 55 |
| abstract_inverted_index.cellular | 100, 197 |
| abstract_inverted_index.cytokine | 77 |
| abstract_inverted_index.efficacy | 81, 177 |
| abstract_inverted_index.pERK1/2. | 127 |
| abstract_inverted_index.promotes | 17 |
| abstract_inverted_index.(γ-H2AX) | 150 |
| abstract_inverted_index.Senescent | 155 |
| abstract_inverted_index.abolished | 146 |
| abstract_inverted_index.attenuate | 92 |
| abstract_inverted_index.decreased | 142 |
| abstract_inverted_index.diseases. | 215 |
| abstract_inverted_index.including | 23 |
| abstract_inverted_index.increased | 71, 160 |
| abstract_inverted_index.inhibitor | 181 |
| abstract_inverted_index.involving | 202 |
| abstract_inverted_index.mechanism | 205 |
| abstract_inverted_index.microglia | 68, 156, 200 |
| abstract_inverted_index.phenotype | 136 |
| abstract_inverted_index.potential | 209 |
| abstract_inverted_index.secretory | 135 |
| abstract_inverted_index.synthetic | 54 |
| abstract_inverted_index.Hexafluoro | 57 |
| abstract_inverted_index.Microglial | 15 |
| abstract_inverted_index.acetylated | 152 |
| abstract_inverted_index.associated | 98 |
| abstract_inverted_index.comparable | 82, 176 |
| abstract_inverted_index.comparison | 51 |
| abstract_inverted_index.contribute | 11 |
| abstract_inverted_index.disorders, | 22 |
| abstract_inverted_index.disorders. | 7 |
| abstract_inverted_index.expression | 73, 115, 123, 132, 161 |
| abstract_inverted_index.illustrate | 186 |
| abstract_inverted_index.microglial | 13 |
| abstract_inverted_index.morphology | 64, 97 |
| abstract_inverted_index.neolignane | 42 |
| abstract_inverted_index.protective | 188 |
| abstract_inverted_index.senescence | 16, 101, 118, 198 |
| abstract_inverted_index.stimulated | 106 |
| abstract_inverted_index.suggesting | 207 |
| abstract_inverted_index.treatments | 129 |
| abstract_inverted_index.alterations | 94 |
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| abstract_inverted_index.officinalis | 45 |
| abstract_inverted_index.production, | 144 |
| abstract_inverted_index.senescence. | 14 |
| abstract_inverted_index.therapeutic | 210 |
| abstract_inverted_index.Inflammation | 8 |
| abstract_inverted_index.contribution | 211 |
| abstract_inverted_index.investigated | 31 |
| abstract_inverted_index.polyphenolic | 41 |
| abstract_inverted_index.Alzheimer’s | 24 |
| abstract_inverted_index.aging-related | 213 |
| abstract_inverted_index.significantly | 110 |
| abstract_inverted_index.LPS-stimulated | 66 |
| abstract_inverted_index.intermittently | 105 |
| abstract_inverted_index.anti-senescence | 35 |
| abstract_inverted_index.overexpression. | 154 |
| abstract_inverted_index.phosphorylation | 149 |
| abstract_inverted_index.pro-inflammatory | 62 |
| abstract_inverted_index.ß-galactosidase | 120 |
| abstract_inverted_index.anti-inflammatory | 76 |
| abstract_inverted_index.neurodegenerative | 6, 21, 214 |
| abstract_inverted_index.neuroinflammation | 1, 195 |
| abstract_inverted_index.Microglia-mediated | 0 |
| abstract_inverted_index.senescence-associated | 134 |
| abstract_inverted_index.anti-neuroinflammatory | 33 |
| abstract_inverted_index.Notch-signaling-mediated | 204 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6399999856948853 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.8791275 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |