The network map of Elabela signaling pathway in physiological and pathological conditions Article Swipe
Shobha Dagamajalu
,
Rex Devasahayam Arokia Balaya
,
G. P. Suchitha
,
Akhila Balakrishna
,
Jan K. Rainey
,
Thottethodi Subrahmanya Keshava Prasad
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1007/s12079-021-00640-4
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1007/s12079-021-00640-4
Elabela (ELA; also called Apela and Toddler) is one of the recently discovered ligand among the two endogenous peptide ligands (Apelin and Elabela) of the apelin receptor (APLNR, also known as APJ). Elabela-induced signaling plays a crucial role in diverse biological processes, including formation of the embryonic cardiovascular system and early placental development by reducing the chances of occurrence of preeclampsia during pregnancy. It also plays the major role in the renoprotection by reducing kidney injury and the inflammatory response and regulation of gene expression associated with heart failure and fibrosis. Elabela may be processed into different active peptides, each of which binds to APLNR and predominantly activates the signals through PI3K/AKT pathway. Owing to its biomedical importance, we developed a consolidated signaling map of Elabela, in accordance with the NetPath criteria. The presented Elabela signaling map comprises 12 activation/inhibition events, 15 catalysis events, 1 molecular association, 34 gene regulation events and 32 protein expression events. The Elabela signaling pathway map is freely made available through the WikiPathways Database ( https://www.wikipathways.org/index.php/Pathway:WP5100 ).
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s12079-021-00640-4
- OA Status
- green
- Cited By
- 14
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3188704765
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3188704765Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s12079-021-00640-4Digital Object Identifier
- Title
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The network map of Elabela signaling pathway in physiological and pathological conditionsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-08-02Full publication date if available
- Authors
-
Shobha Dagamajalu, Rex Devasahayam Arokia Balaya, G. P. Suchitha, Akhila Balakrishna, Jan K. Rainey, Thottethodi Subrahmanya Keshava PrasadList of authors in order
- Landing page
-
https://doi.org/10.1007/s12079-021-00640-4Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/8688647Direct OA link when available
- Concepts
-
Apelin, Signal transduction, Biology, PI3K/AKT/mTOR pathway, Bioinformatics, Computational biology, Receptor, Cell biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 3, 2023: 2, 2022: 7Per-year citation counts (last 5 years)
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41Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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