The Notch1 gene may control cell chemoresistance in esophageal squamous cell cancer Article Swipe
Kun Gao
,
Wenqun Xing
,
Xianben Liu
,
Jizhao Liu
,
Haibo Sun
,
Wentao Hao
,
Yan Zheng
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21037/tcr-21-447
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21037/tcr-21-447
Notch1 gene missense mutation leads to an increase in the number of water-bridge bonds, thus enhancing the Notch1-DLL4 interaction, which may lead to tighter Notch1-DLL4 binding, either making the pathway easier to activate or increasing the length of time it is active.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.21037/tcr-21-447
- https://tcr.amegroups.com/article/viewFile/53255/pdf
- OA Status
- diamond
- Cited By
- 9
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3175058099
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3175058099Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21037/tcr-21-447Digital Object Identifier
- Title
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The Notch1 gene may control cell chemoresistance in esophageal squamous cell cancerWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-06-24Full publication date if available
- Authors
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Kun Gao, Wenqun Xing, Xianben Liu, Jizhao Liu, Haibo Sun, Wentao Hao, Yan ZhengList of authors in order
- Landing page
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https://doi.org/10.21037/tcr-21-447Publisher landing page
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https://tcr.amegroups.com/article/viewFile/53255/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://tcr.amegroups.com/article/viewFile/53255/pdfDirect OA link when available
- Concepts
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Missense mutation, Homology modeling, In silico, Gene, Biology, Mutation, Docking (animal), Protein Data Bank (RCSB PDB), Genetics, Computational biology, Cancer research, Biochemistry, Medicine, Nursing, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 4, 2023: 1, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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