The organization and developmental establishment of cortical interneuron presynaptic circuits Article Swipe
Gabrielle Pouchelon
,
Yannick Bollmann
,
Elaine Fisher
,
Chimuanya K. Agba
,
Qing Xu
,
Kimberly Ritola
,
Andrea MC Mirow
,
Sehyun Kim
,
Rosa Cossart
,
Gord Fishell
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.09.17.302117
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.09.17.302117
Sensory and cognitive functions are processed in discrete cortical areas and depend upon the integration of long range cortical and subcortical inputs. PV and SST inhibitory interneurons (cINs) gate these inputs and failure to do so properly is implicated in many neurodevelopmental disorders. The logic by which these interneuron populations are integrated into cortical circuits and how these vary across sensory versus associative cortical areas is unknown. To answer this question, we began by surveying the breadth of afferents impinging upon PV and SST cINs within distinct cortical areas. We found that presynaptic inputs to both cIN populations are similar and primarily dictated by their areal location. By contrast, the timing of when they receive these afferents is cell-type specific. In sensory regions, both SST and PV cINs initially receive thalamocortical first order inputs. While by adulthood PV cINs remain heavily skewed towards first order inputs, SST cINs receive an equal balance of first and higher order thalamic afferents. Remarkably, while perturbations to sensory experience affect PV cIN thalamocortical connectivity, SST cIN connectivity is disrupted in a model of fragile X syndrome (Fmr1 loss of function) but not a model of ASD (Shank3B loss of function). Altogether, these data provide a comprehensive map of cIN afferents within different functional cortical areas and reveal the region-specific logic by which PV and SST cIN circuits are established.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.09.17.302117
- https://www.biorxiv.org/content/biorxiv/early/2020/09/17/2020.09.17.302117.full.pdf
- OA Status
- green
- Cited By
- 4
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3084517543
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3084517543Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.09.17.302117Digital Object Identifier
- Title
-
The organization and developmental establishment of cortical interneuron presynaptic circuitsWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-09-17Full publication date if available
- Authors
-
Gabrielle Pouchelon, Yannick Bollmann, Elaine Fisher, Chimuanya K. Agba, Qing Xu, Kimberly Ritola, Andrea MC Mirow, Sehyun Kim, Rosa Cossart, Gord FishellList of authors in order
- Landing page
-
https://doi.org/10.1101/2020.09.17.302117Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/09/17/2020.09.17.302117.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/09/17/2020.09.17.302117.full.pdfDirect OA link when available
- Concepts
-
Neuroscience, Sensory system, Interneuron, Inhibitory postsynaptic potential, Thalamus, Biology, PsychologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2022: 2, 2021: 2Per-year citation counts (last 5 years)
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66Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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