The outcome of surgery for congenital heart disease in India: A systematic review and metanalysis Article Swipe
Lamk Kadiyani
,
Mani Kalaivani
,
Krishna Subramony Iyer
,
Sivasubramanian Ramakrishnan
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4103/apc.apc_71_24
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4103/apc.apc_71_24
Background: The mortality risks of children undergoing various cardiac surgeries for congenital heart disease (CHD) in India are not well defined. We conducted a systematic review and meta-analysis to estimate the inhospital mortality of various common CHD surgeries reported in India and compared it to representative data from established Western databases. Methods and Results: We searched four bibliographic databases for studies published in India over the last 25 years. In total, 135 studies met the inclusion criteria and included 30,587 patients aged from 1 day to 65 years. The pooled mortality rate of 43 Indian studies reporting multiple CHD surgical outcomes is 5.63% (95% confidence interval [CI]: 4.26–7.16; I 2 = 93.9%), whereas the Western data showed a pooled mortality rate of 2.65% ( P value for comparison <0.0001). The pooled mortality risk for ventricular septal defect closure and tetralogy of Fallot repair in Indian studies was 2.87% (95% CI: 0.76–5.91; I 2 = 62.4%) and 4.61% (95% CI: 2.0–8.02; I 2 = 87.4%), respectively. The estimated mortality risk was higher than the Western databases for all subcategories studied except for surgeries in the grown-ups with CHD population and coarctation repair. Conclusions: The estimated mortality risks are higher among Indian patients undergoing cardiac surgery for CHD as compared to Western data. We need prospective multicentric data to document whether the observed excess mortality exists after adjusting for various high-risk features and comorbidities in Indian patients. We need systemic measures to improve the outcomes of CHD surgeries in India.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.4103/apc.apc_71_24
- OA Status
- diamond
- Cited By
- 16
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4403074398Canonical identifier for this work in OpenAlex
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https://doi.org/10.4103/apc.apc_71_24Digital Object Identifier
- Title
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The outcome of surgery for congenital heart disease in India: A systematic review and metanalysisWork title
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reviewOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-05-01Full publication date if available
- Authors
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Lamk Kadiyani, Mani Kalaivani, Krishna Subramony Iyer, Sivasubramanian RamakrishnanList of authors in order
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https://doi.org/10.4103/apc.apc_71_24Publisher landing page
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diamondOpen access status per OpenAlex
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https://doi.org/10.4103/apc.apc_71_24Direct OA link when available
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Medicine, Confidence interval, Tetralogy of Fallot, Mortality rate, Meta-analysis, Population, Risk of mortality, Cardiac surgery, Heart disease, Pediatrics, Internal medicine, Surgery, Environmental healthTop concepts (fields/topics) attached by OpenAlex
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16Total citation count in OpenAlex
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2025: 11, 2024: 5Per-year citation counts (last 5 years)
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